Hypersensitivity News and Research

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Hypersensitivity is an exaggerated response by the immune system to a drug or other substance.

β-damascone can function as an efficient modulator of dendritic cell-mediated functions

Dendritic cells (DCs) are important players of the immune system with important functions such as the identification of infectious pathogens, production of cytokines (chemical signalers of the immune system), presentation of antigens to activate T-cells, and more.

10 Feb 2023

A microbiota-driven mechanism underlies severity of leishmaniasis infection

In a recent study posed to the medRxiv* preprint server, researchers in Brazil and the United States investigated the probable impact of the skin microbiome microbiota on the outcomes of cutaneous leishmaniasis.

8 Feb 2023

Eczema in young individuals remains a substantial public health burden in most countries

New research published in Clinical & Experimental Allergy indicates that the burden related to eczema in young individuals is substantial in most countries.

8 Feb 2023

Autistic individuals experience pain at a higher intensity than general population, study finds

A new study has examined the pain perception among people with autism and found that they experience pain at a higher intensity than the general population and are less adaptable to the sensation.

29 Jan 2023

Study describes a mechanism associated with the production of neuropathic pain

Neuropathic pain is a type of chronic pain caused by damage to the nervous system due mainly to metabolic diseases such as diabetes and arthritis, or to the side effects of some kinds of chemotherapy.

10 Jan 2023

Acupuncture could be a safe and feasible management option for IBS-D

Researchers preliminarily evaluated the practicality of utilizing the United States (US) Food and Drug Administration (FDA)-advocated endpoints to assess the effectiveness of acupuncture in IBS-D (irritable bowel syndrome with diarrhea) management.

5 Jan 2023

Researchers develop a lateral flow test to reliably identify and quantify allergens in foods

A team from the Universitat Politècnica de València, the Universitat de València, and the Centro de Investigación Biomédica en Red sobre Enfermedades Raras has developed a lateral flow test that identifies and quantifies the level of allergens reliably in food with the help of a smartphone.

23 Dec 2022

Targeting Piezo2 could provide new avenue for treating chronic pain related to gastrointestinal disorders

Targeting a receptor responsible for our sense of touch and temperature, which researchers have now found to be present in our colon, could provide a new avenue for treating chronic pain associated with gastrointestinal disorders such as irritable bowel syndrome.

23 Dec 2022

Mice study sheds light on how the brain's primary motor cortex helps suppress neuropathic pain

A new study in mice has helped illuminate how the brain's primary motor cortex (M1) – a brain region most commonly associated with control of motor functions – helps suppress dimensions of neuropathic pain.

22 Dec 2022

New study questions the perception that autistic individuals experience less pain

People with autism have normal pain thresholds but increased sensitivity to painful stimuli, concludes a study in PAIN, the official publication of the International Association for the Study of Pain.

30 Nov 2022

Flavonoids with potential to fight allergies and inflammation

In a recent study published in the Biomedicine & Pharmacotherapy journal, researchers explored the anti-allergic and anti-inflammatory properties of flavonoids.

28 Nov 2022

Two studies reveal insights into how the spinal cord and brainstem contribute to sense of touch

The sense of touch is essential to almost everything we do, from routine tasks at home to navigating unfamiliar terrains that may conceal dangers.

23 Nov 2022

FDA approves first-ever type 1 diabetes delaying drug Tzield (teplizumab-mzwv)

On November 17, 2022, the US Food and Drug Administration (FDA) approved a pathbreaking new drug called Tzield. This injectable formulation contains a combination of two drugs that could push back the onset of type 1 diabetes (T1D) in adults at stage 3 and children aged eight years or more at stage 2.

20 Nov 2022

Children exposed to air pollution in early years more likely to develop food allergies

A new research paper explores associations between food allergies and pre- or post-natal exposure to pollutants in the air, thus paving the way for future studies on the potential sensitization of the gut by exposure of the skin or airway to pollutants, in addition to the alimentary route.

7 Nov 2022

Study uses pluripotent stem cell models to investigate stress response in PTSD patients

Stem cell-derived neurons from combat veterans with post-traumatic stress disorder (PTSD) react differently to a stress hormone than those from veterans without PTSD, a finding that could provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure.

20 Oct 2022

Study reveals why viral infections are less frequent but more severe in individuals with Down syndrome

Individuals with Down syndrome have less-frequent viral infections, but when present, these infections lead to more severe disease.

14 Oct 2022

The compositional and functional diversity of the gut fungal microbiome

Researchers assessed the role of gut bacterial microbiome assembly and the gut mycobiome in relation to health, pathology, and clinical applications.

30 Sep 2022

Debunking ‘man flu’

Researchers debunk man flu based on a review of available evidence.

28 Sep 2022

New guideline for the evaluation and testing of patients with penicillin allergies

A new guideline published in Clinical & Experimental Allergy will help clinicians evaluate and test patients for potential penicillin allergies.

21 Sep 2022

Daily multivitamin improves cognitive function in seniors

In a recent study published in the journal Alzheimer's & Dementia, researchers in the United States investigated whether daily administration of a cocoa extract (CE, comprising 500 mg flavanols, including 80 mg epicatechins, 50 mg/day theobromine (50 mg/day), and 15mg/day caffeine) and/or an MVM (multivitamin-mineral) for three years protected cognitive functions among older men and women.

18 Sep 2022