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CASGEVY gene therapy eliminates vaso-occlusive crises in sickle cell patients

In a landmark study, an international consortium led by researchers at Children's Hospital of Philadelphia (CHOP) published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs).

24 Apr 2024

Prostaglandin E2: The culprit behind tumor immune evasion

Tumors actively prevent the formation of immune responses by so-called cytotoxic T cells, which are essential in combating cancer. Researchers at the Technical University of Munich (TUM) and the Ludwig-Maximilians-Universität München (LMU) Hospital have now uncovered for the first time how this exactly happens.

24 Apr 2024

Brain dynamics and BMI linked to dieting success, study finds

Research reveals that individuals with higher BMI and extensive brain modifications during diet decisions tend to have lower success in diet modification, suggesting the impact of neural plasticity and BMI on diet adherence.

23 Apr 2024

Emulsifiers in processed foods may be linked to increased risk of type 2 diabetes

In Europe and North America, 30 to 60% of dietary energy intake in adults comes from ultra-processed foods.

23 Apr 2024

$4.8 million grant supports research on TDP-43 misfolding in neurodegenerative diseases

A new $4.8 million grant will support researchers from Indiana University School of Medicine and the Medical Research Council Laboratory of Molecular Biology to study how human neurodegenerative diseases are affected by the misfolding of the protein TDP-43.

23 Apr 2024

Study identifies molecular pathway in liver cancer development

As a malignant disease of the liver cells, hepatocellular carcinoma (HCC) is one of the main causes of cancer-related deaths.

23 Apr 2024

Researchers aim to use AI for early screening and prognosis of Dry Eye Disease

Dry Eye Disease (DED) is one of the more common eye diseases, affecting up to 30% of the world's population.

23 Apr 2024

US study links extended sitting and lack of coffee to higher death rates

The independent and combined effects of daily sedentary times and coffee consumption on cardiovascular disease.

23 Apr 2024

Study discovers hidden mechanism behind rapid COVID variants

The SARS-CoV-2 virus that causes COVID has the unsettling ability of often generating variants of itself. Other viruses also mutate, but as SARS-CoV-2 quickly spread throughout the entire human population during the pandemic, killing millions, the virus' dynamic evolution posed a serious problem: it repeatedly challenged our bodies' immune response fighting the virus and hindered the process of getting updated vaccines ready.

23 Apr 2024

New technique tracks drug use through smartphones

A simple and convenient method to collect drug use data from the surface of a smartphone is revealed for the first time in a new study published in De Gruyter's Clinical Chemistry and Laboratory Medicine. By helping clinicians understand what drugs people are taking in certain contexts, the research could protect public health and improve the treatment of patients suspected of overdosing.

23 Apr 2024

Study shows meth users have lower empathy and higher aggression, ecstasy users show normal empathy but more impulsive aggression

A study in the European Neuropsychopharmacology journal finds that methamphetamine users show lower empathy and higher aggression, whereas ecstasy (MDMA) users exhibit increased impulsive aggression but normal empathy levels.

23 Apr 2024

Study reveals avocado may lower diabetes risk in women, not men

A recent study in the Journal of the Academy of Nutrition and Dietetics found that avocado consumption is associated with a reduced risk of diabetes in Mexican women, but not in men, highlighting potential gender-specific dietary benefits.

23 Apr 2024

Large-scale study identifies new approach to early Alzheimer's detection

Digital memory test and a blood sample - this combination will be tested for its potential to identify early Alzheimer's disease in a new research study. Over a hundred healthcare centers are part of the study that is now inviting participants to sign up. At least 3,000, preferably many more participants are needed for the study to be successful.

23 Apr 2024