Leptin News and Research

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Leptin is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. It is one of the most important adipose derived hormones. The ''Ob(Lep)'' gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans.

Biological BMI measures metabolic health more accurately

Researchers analyze longitudinal and cross-sectional changes in blood analytes associated with variations in body mass index.

23 Mar 2023

Childhood and adolescent obesity: time to act

In a recent review published in the journal Frontiers in Pediatrics, researchers at the Medical College of Wisconsin presented an overview of the pathophysiological mechanisms, health implications, and management options for obesity among children and adults.

21 Mar 2023

Poor inflammatory immune response in obese patients increases susceptibility to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

20 Mar 2023

Long-acting GIPRA inhibits feeding and lowers body weight in mice with diet-induced obesity

The hormone glucose-dependent insulinotropic polypeptide (GIP) is considered obesogenic. In contrast, GIP receptor agonists (GIPRAs) have shown reduced feeding and body weight in an obese mouse model. Therefore, the precise effects exerted by GIP and GIPRAs remain elusive.

14 Mar 2023

Hypothalamic inflammation and obesity, study suggests a pathological mechanism

In a recent review published in the European Journal of Endocrinology, researchers discussed current research on the relationship between human obesity and inflammation of the hypothalamus.

14 Mar 2023

How gut microbiota control feelings of fullness after eating

A recent study discusses recent findings linking satiety to the gut microbiome.

7 Mar 2023

Study paves the way to new sex-specific anti-obesity drugs

Sex differences exist in the regulation of energy homeostasis, the organism's mechanism to keep a stable body weight. Current studies indicate for instance that female mammals, including humans, are better protected against metabolic diseases during reproductive age.

7 Mar 2023

Pennington Biomedical assistant professor seeks to better understand why people with diabetes develop hypoglycemia

For someone with type 1 diabetes, it's imperative they test their blood sugar levels regularly, and insulin is utilized to keep blood sugar regulated.

23 Feb 2023

Immunological interactions between asthma, obesity, and the microbiota

This study summarizes the mechanisms associated with obesity-aggravated asthma.

18 Jan 2023

Correlating circulating adipokine levels with COVID-19 severity

Researchers determine whether plasma adipokine levels were associated with COVID-19-related systemic inflammation and severity.

14 Dec 2022

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

What drives tumor growth? Is it a few rogue cells imposing their will upon healthy tissue, or diseased tissue bringing out the worst in otherwise peaceable cells? Or is it a back-and-forth, a dialogue between the two?

30 Nov 2022

Gut microbiome plays a role in Alzheimer's

In a recent review published in the journal Pharmacological Research, researchers in Brazil investigated the role of gut microbiota in cognition, brain function, behavior, and neurodegenerative disease pathogenesis.

17 Nov 2022

Ketogenic diet may show more promising results than Mediterranean diets in short-term type 2 diabetes management

Researchers evaluated the short-term impact of the very-low-calorie ketogenic diet (VLCKD) and Mediterranean diet (MD) on the gut microbiota (GM) of obese patients with new-onset type II diabetes (T2DM).

15 Nov 2022

Johns Hopkins researchers uncover a possible target to treat sleep apnea

In a new study with obese mice, Johns Hopkins Medicine researchers say they have added to evidence that specialized channel proteins are possible therapeutic targets for sleep apnea and similar abnormally slow breathing disorders in obese people.

31 Oct 2022

Rheumatoid arthritis drug can be repurposed to improve diabetes-associated symptoms

Researchers at Baylor College of Medicine and collaborating institutions discovered that the rheumatoid arthritis drug auranofin can potentially be repurposed to improve diabetes-associated symptoms.

14 Oct 2022

Study opens up new approaches for treating fatty liver disease

A study group at MedUni Vienna has identified a regulatory loop controlled by leptin, by which this adipocyte-derived hormone regulates hepatic lipid metabolism via the autonomic nervous system.

11 Oct 2022

Does leptin play a role in Parkinson’s disease?

Scientists review in vitro and in vivo evidence associated with Parkinson's disease and leptin.

26 Sep 2022

Excessive smartphone use may lead to early puberty

Exposure to blue light via regular use of tablets and smartphones may alter hormone levels and increase the risk of earlier puberty, according to data from a rat study presented today at the 60th Annual European Society for Paediatric Endocrinology Meeting.

16 Sep 2022

Obese children who recently lost weight more likely to show hunger-related brain activity after a meal

Children with obesity, who have recently lost weight, are more likely to show hunger-related activity in their brains after a meal, according to research presented today at the 60th Annual European Society for Paediatric Endocrinology Meeting.

15 Sep 2022

Eating disorders could be treated by modulating gut microbiota

Researchers describe how the gut-brain axis facilitates communication between the gastrointestinal tract and brain to regulate food consumption behaviors.

17 Aug 2022