Lipidomics News and Research

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Lipidomics refers to the study of cellular lipidomes, meaning the network of lipid constituents that maintain cellular and bodily health.

Seed oils are best choice for improving cholesterol

If you want to lower your low-density lipoprotein cholesterol, called LDL or, colloquially, "bad cholesterol," the research is clear about one thing: You should exchange saturated fats with unsaturated fat. If you want to know what you should use to sauté your dinner, that's a harder question to answer. Many of the studies establishing that mono- and polyunsaturated fats are better for blood lipids than saturated fats swapped out one food source at a time, making it hard to tell which of a plethora of vegetable oils might be most beneficial.

9 Oct 2018

New studies examine links between fatty liver disease and mitochondrial dysfunction

Researchers at Northeast Ohio Medical University studied the lifespan of mitochondrial proteins in a mouse model of fatty liver disease. Comparing the amount of protein between healthy mice and a mouse model of nonalcoholic fatty liver disease gave them an estimate of each protein's half-life.

17 Sep 2018

Study provides insight into link between sleep apnea and lipid metabolism

Obstructive sleep apnea is a clinical disorder characterized by repeated partial or complete blockage of the airway during sleep.

15 Aug 2018

Structure of a long-chain lipid that keeps our tears clear revealed

As anyone who has experienced an annoying alternation between dry and watery eyes can confirm, tears alone aren't enough to keep the eye from drying out. A microscopically thin film of oils known as the tear film lipid layer is key to preventing the tear film from evaporating.

9 Aug 2018

Researchers explore why heart failure and kidney disease correlate

People with chronic kidney disease are at unusually high risk of also developing cardiovascular disease; in fact, a patient with non-dialysis kidney disease is more likely to die of heart failure than to develop end-stage kidney failure.

24 Jul 2018

Extensive lipidomics studies reveal signatures of metabolic health and disease

Scientists from EPFL and the University of Wisconsin-Madison have carried out one of the most extensive lipidomics studies to date, connecting almost 150 different lipid species to their respective genetic regulators, revealing signatures of metabolic health and disease.

13 Jun 2018

Researchers take important step toward finding protein biomarkers during cancer surgery

Isabelle Fournier and her team are out to change surgical oncology. "Better surgery is associated with better prognosis and higher survival," said Fournier, a professor at the University of Lille and co-director of a proteomics center of INSERM, the French national institute of health.

24 May 2018

Researchers reveal how tumor cells disrupt circadian rhythm to survive

Tumor cells use the unfolded protein response to alter circadian rhythm, which contributes to more tumor growth, Hollings Cancer Center researchers at the Medical University of South Carolina find.

28 Dec 2017

Exosome isolation using ultracentrifugation

In the outpatient clinic and lab, our research studies aim to understand biological functions of exosomes and membrane particles.

From Beckman Coulter Life Sciences - Centrifugation 9 Feb 2017

Taking omega-3 supplements during pregnancy can reduce risk of childhood asthma by one third

Taking certain omega-3 fatty acid supplements during pregnancy can reduce the risk of childhood asthma by almost one third, according to a new study from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) and the University of Waterloo.

30 Dec 2016

Novel lipid-based therapeutic shows promise for combating drug resistance in AML

Researchers at the Medical University of South Carolina Hollings Cancer Center have discovered a mechanism that confers resistance to drugs used to treat certain types of acute myeloid leukemia (AML).

24 Oct 2016

MUSC Hollings Cancer Center receives $8.9 million grant to explore signaling in sphingolipids

The Medical University of South Carolina's Hollings Cancer Center received an $8.9 million grant from the National Cancer Institute designed to foster collaboration across clinical and laboratory research for the study of signaling in sphingolipids, a class of lipids known to be involved in the growth of solid tumor cancers.

10 May 2016

Understanding how individuals respond to aspirin

Researchers have learned new information about how different people respond to aspirin, a globally prescribed drug in cardioprotection. The research team, led by scientists at Cardiff University in the United Kingdom and including representatives from the University of Alabama at Birmingham and the University of Colorado, identified more than 5,600 lipids — or fats — in blood platelets and gained new insights into how these cells respond to aspirin.

29 Apr 2016

New analytical tool may help diagnose cancer faster than conventional methods

Researchers have developed a new analytical tool for medical applications and biological research that might be used to diagnose cancer more rapidly than conventional methods.

26 Feb 2016

Sphingosine kinase inhibitor slows castration-resistant prostate cancer cell growth

A first-in-class sphingosine kinase 2 inhibitor slowed the growth of castration-resistant prostate cancer cells, in part by inhibiting the enzyme dihydroceramide desaturase (DEGS), but did not kill them, according to the results of preclinical in vitro and in vivo studies published in the December 2015 issue of Molecular Cancer Therapeutics by researchers at the Medical University of South Carolina and others.

30 Jan 2016

Scientists reveal why non-alcoholic steatohepatitis worsens in obese people

In results published on October 19, 2015 in the Journal of Lipid Research, a team of translational scientists at the Medical University of South Carolina report a new reason why non-alcoholic steatohepatitis (NASH) worsens in people who are obese.

20 Jan 2016

SLU VTEU awarded $5.8 million NIH contract to support 'omics' research initiative

Saint Louis University's Vaccine and Treatment Evaluation Unit has received a five-year, $5.8 million contract from the National Institutes of Health to support an "omics" research initiative to study the safety and effectiveness of vaccines and other ways to fight infectious diseases.

30 Oct 2015

JDRF-funded study aims to find new types of diagnostic markers for diabetic kidney disease

In an effort to pinpoint the earliest signs of diabetic kidney disease, researchers at University of California, San Diego School of Medicine are leading a multi-institutional international effort dedicated to finding a new breed of disease indicators.

23 Oct 2015

SCIEX and Metabolon® Launch the Lipidyzer™ Platform for Complete Lipid Analysis, from Sample to Biology

The new Lipidyzer™ Platform enables you to rapidly and accurately differentiate and quantitate over a thousand lipid species, and translates your data into knowledge with ease and efficiency.

4 Jun 2015

Denator's heat-stabilization system preserves lipids at close-to-in vivo-levels

Denator AB announced today that the company’s heat-stabilization system has been demonstrated to preserve lipids at close-to-in vivo-levels. To preserve lipids in a reliable manner prior to mass spectrometry-based analysis is pivotal to accurately quantify and identify potential biomarkers and perform disease research.

19 Mar 2015