Pathophysiology News and Research

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An outsider's view of chronic fatigue syndrome may provide clues to how we perceive

Clinical methodology and its implications for the study of therapeutic interventions for chronic fatigue syndrome (CFS).

28 Jun 2006

Evidence is strong that green tea lowers the risk for a number of chronic diseases

There is a lower incidence of cardiovascular disease and cancer in Asia where people smoke heavily, which may be accounted for by high consumption of tea, particularly green tea, according to a review article published by a Yale School of Medicine researcher.

6 Jun 2006

Gene variation linked to more severe Crohn's disease

Building on previous evidence supporting the theory that the pathophysiology of Crohn's Disease is altered by genetic variation, recent studies have found that the combination of immune signals given by three variants of a single candidate gene affects the severity of the disease.

1 Jun 2006

New diagnostic approaches for early identification of patients at high risk of rapid loss of kidney function

Doctor Harry Holthvfer, M.D., Ph.D, at the University of Helsinki, Finland, coordinates a new EU-funded project, which aims to develop new diagnostic approaches for early identification of patients at high risk of rapid loss of kidney function.

31 May 2006

Endocannabinoid system shows promise in combating obesity

As the obesity epidemic grows in the United States, the medical community is faced with the significant challenge of properly treating patients before complications such as heart disease arise.

3 May 2006

Intensive statin therapy shows promise for inducing regression of coronary atherosclerosis

Patients treated with very intensive statin therapy lowered LDL-C levels on average by about 50 percent, increased HDL-C levels by 15 percent, and showed regression of coronary atherosclerosis

15 Mar 2006

Tomato juice keeps emphysema from developing in new animal model of degenerative disease

Feeding tomato juice to mice kept them from developing emphysema after cigarette smoke exposure that was long enough to induce emphysema in a control group, Japanese researchers report in February issue of the American Journal of Physiology-Lung Cellular and Molecular Physiology.

10 Jan 2006

Intravenous lidocaine and oral derivatives relieve pain from damage to the nervous system

Lidocaine and similar local anesthetics are effective for treating pain that emanates from damaged nerves, according to a systematic review of current evidence.

23 Oct 2005

Hundreds of identified genes involved in the pathophysiology of ulcerative colitis and Crohn disease

In a paper published in PLoS Medicine researchers from the German Genome Research Network have analysed the expression of thousands of genes from patients with inflammatory bowel disease (ulcerative colitis and Crohn disease) using a genome wide approach to produce a comprehensive picture of which genes are activated in these conditions.

24 Aug 2005

Current clinical practice guidelines are not written with older adults with multiple illnesses in mind

The aging of the population and the increasing prevalence of chronic diseases pose challenges to the development and application of clinical practice guidelines (CPGs), according to background information in the article. In 1999, 48 percent of Medicare beneficiaries aged 65 years or older had at least 3 chronic medical conditions and 21 percent had 5 or more.

10 Aug 2005

Plaques in the brain more likely to be expressed as dementia in women than in men

Researchers from the Rush Alzheimer's Disease Center found that plaques and tangles in the brain, the changes seen in people with Alzheimer's disease (AD), are more likely to be expressed as dementia in women than in men.

25 Jul 2005

Fetal Alcohol Syndrome (FAS) occurs far more frequently than generally believed

Although estimates vary widely, when combined with the milder afflictions of Alcohol Related Birth Defects (ARBD) and several others, the Centers for Disease Control puts the frequency of FAS/ARBD as high as one in 100.

19 Jul 2005

Blood testing links common foods and irritable bowel syndrome

Researchers using comparison trials determined that irritable bowel syndrome (IBS) patients have elevated food-specific IgG4 antibodies to common foods such as wheat, beef, pork, lamb, and soya bean. These findings are published in the July issue of The American Journal of Gastroenterology.

13 Jul 2005

Help for osteoporosis sufferers in the primary care office

A primary care practitioner can help improve quality of life and mobility for those who suffer from pain resulting from osteoporosis-related fractures by referring a patient for two relatively new non-invasive procedures.

29 Jun 2005

Wearing a continuous positive airway pressure device helps heart failure patients with obstructive sleep apnea get a good night's rest

Wearing a continuous positive airway pressure (CPAP) device not only helps heart failure patients with obstructive sleep apnea get a good night's rest, it lowers blood pressure and heart rate well into the morning, apparently, by reducing sympathetic nervous system activity, according to a new study (PDF) in the June 21, 2005, issue of the Journal of the American College of Cardiology.

21 Jun 2005

Abnormal heart scans predict higher risks for African-Americans and Hispanics

SPECT imaging scans show that abnormalities in blood flow to the muscle of the heart indicate higher cardiovascular disease risk in African-Americans and Hispanics than similar abnormalities in white patients, according to a new study (PDF) in the May 3, 2005, issue of the Journal of the American College of Cardiology.

4 May 2005

Problem gambling associated with brain impairments

Pathological gamblers exhibit complex impairments in decision-making and executive function processes associated with the prefrontal cortex of the brain, according to research that will be presented at the American Academy of Neurology 57th Annual Meeting in Miami Beach, Fla., April 9 – 16, 2005.

13 Apr 2005

Mathematical model describes the electrical storm that rages during a brain seizure

"We're trying to get to the underlying state of the brain that leads to these seizures," said Mark Kramer, a Ph.D. student in UC Berkeley's Applied Science and Technology Program and lead author of the paper. "Our hope is that the model can highlight potential areas where a seizure can be stopped."

24 Feb 2005

Malaria experts to unveil top-flight research during international conference

Some of the world’s leading authorities on tropical diseases and parasitic infections will gather for an international conference at The University of Nottingham to discuss the latest breakthroughs in research and treatments.

3 Feb 2005

Heart bypass gets new source for replacement blood vessels

The search for a stable, renewable source of blood vessels, especially for potential use in heart bypass surgery, has reached a milestone at the State University of New York at Buffalo.

11 Nov 2004