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New monoclonal antibody vaccine slashes malaria risk in children

A recent study demonstrates that the monoclonal antibody-based vaccine L9LS is safe for children aged 6 to 10 and significantly reduces the risk of malaria infection and clinical symptoms by 70% and 77%, respectively.

30 Apr 2024

U of T researchers develop new approach for controlling neuron generation in Parkinson's disease

Researchers at the University of Toronto have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease, pointing toward a new approach for a disease with no cure and few effective treatments.

30 Apr 2024

Genetic propensity to higher arachidonic acid levels linked to lower bipolar disorder risk

A genetic propensity to higher circulating levels of lipids containing arachidonic acid, an omega-6 polyunsaturated fatty acid found in eggs, poultry, and seafood, has been found to be linked with a lower risk for bipolar disorder, according to a new study in Biological Psychiatry, published by Elsevier.

30 Apr 2024

Genetic associations of key genes in breast cancer pathogenesis

Breast cancer remains a significant global health concern, warranting further exploration into its genetic basis and potential therapeutic targets.

29 Apr 2024

Parkinson’s UK invests £2.1 million in Neumora Therapeutics for preclinical testing of new Parkinson’s drug

Parkinson’s UK is investing £2.1million to support Neumora Therapeutics to carry out preclinical testing of NMRA-NLRP3, a NLRP3 inhibitor with the potential to reduce inflammation and protect brain cells in Parkinson’s. NLRP3 is a protein that plays a role in regulating a number of inflammatory processes that are believed to contribute to the damage to brain cells that underlies Parkinson’s.

27 Apr 2024

Study reveals surprising role of maternal cytokines in offspring psychiatric risk

Researchers at Weill Cornell Medicine have discovered in a preclinical model that cytokines, proteins that control immune response, circulating in maternal blood during pregnancy may mitigate an offspring's risk for psychiatric conditions.

25 Apr 2024

Synthetic nanomaterial could be an effective tool for treating neurodegenerative diseases

A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases.

25 Apr 2024

Insilico Medicine's AI-designed drug ISM3412 receives FDA IND approval

Clinical stage artificial intelligence (AI)-driven drug discovery company Insilico Medicine announces that it has received approval from the U.S. Food and Drug Administration for its Investigational New Drug application for ISM3412, a small molecule inhibitor of MAT2A for the potential treatment of MTAP deleted cancers designed with Insilico's generative AI platform.

25 Apr 2024

Therapeutic potential of human umbilical cord-derived mesenchymal stem cells in Crohn’s disease

Whether human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) could heal luminal ulcers in Crohn’s disease.

25 Apr 2024

MSU team creates a promising vaccine candidate for antibiotic-resistant bacteria

Driven by the overuse of antimicrobials, pathogens are quickly building up resistances to once-successful treatments.

24 Apr 2024

Innovative malaria prodrug targets liver, enhances efficacy while reducing toxicity, preclinical studies show

Tafenoquine, a prodrug that could fulfill the criteria for a mass eradication campaign.

23 Apr 2024

CN Bio raises $21 million USD in first close of Series B investment round

Bayland Capital and founding shareholder, CN Innovations Holdings Ltd, to invest $10 M and $5.5 M, respectively. Investment will expand product development and scaling of the organization to meet increased demand for Organ-on-a-Chip (OOC) solutions.

23 Apr 2024

Research explores how moms' obesity reprograms babies

Research increasingly suggests that when a woman with obesity becomes pregnant, a process of "fetal reprogramming" increases the risk that her baby will face problems like obesity, Type 2 diabetes and liver disease earlier in life.

23 Apr 2024

New tool hunts for Alzheimer's clues in gut microbiome

Cleveland Clinic researchers are using artificial intelligence to uncover the link between the gut microbiome and Alzheimer's disease.

23 Apr 2024

Unveiling pancreatic mysteries: 3D imaging redefines islet cell distribution

Researchers at Umeå University have succeeded in imaging an entire human organ, a pancreas, in microscopic resolution.

22 Apr 2024

Gut bacteria manipulation may offer a promising approach to managing inflammatory bowel disease

A growing body of research suggests that manipulating gut bacteria may offer a promising approach to managing inflammatory bowel disease (IBD), a chronic and debilitating condition affecting millions of people worldwide.

22 Apr 2024

Liver cells effectively serve as immune checkpoint regulating anti-cancer immunity

Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer outcomes and more recently associated with poor response to immunotherapy.

22 Apr 2024

Insightful review explores alcohol-related liver cancer pathogenesis

While heavy drinking is a well-established risk factor for liver cancer, the specific mechanisms by which alcohol contributes to A-HCC remain unclear.

22 Apr 2024

Engineered peptides show promise in cancer immunotherapy

In a new study published today in Nature Biomedical Engineering, researchers at The University of Texas MD Anderson Cancer Center have designed a new method for developing immunotherapy drugs using engineered peptides to elicit a natural immune response inside the body.

22 Apr 2024

Researchers receive NIH grant to help develop gene therapy for HIV

Researchers at Washington University School of Medicine in St. Louis have received a $6.2 million grant from the National Institutes of Health (NIH) to develop a gene therapy that would modify the immune system's B cells to spur them to produce broadly neutralizing antibodies against HIV.

18 Apr 2024

Preclinical News and Research

New monoclonal antibody vaccine slashes malaria risk in children

U of T researchers develop new approach for controlling neuron generation in Parkinson's disease

Genetic propensity to higher arachidonic acid levels linked to lower bipolar disorder risk

Genetic associations of key genes in breast cancer pathogenesis

Parkinson’s UK invests £2.1 million in Neumora Therapeutics for preclinical testing of new Parkinson’s drug

Study reveals surprising role of maternal cytokines in offspring psychiatric risk

Synthetic nanomaterial could be an effective tool for treating neurodegenerative diseases

Insilico Medicine's AI-designed drug ISM3412 receives FDA IND approval

Therapeutic potential of human umbilical cord-derived mesenchymal stem cells in Crohn’s disease

MSU team creates a promising vaccine candidate for antibiotic-resistant bacteria

Innovative malaria prodrug targets liver, enhances efficacy while reducing toxicity, preclinical studies show

CN Bio raises $21 million USD in first close of Series B investment round

Research explores how moms' obesity reprograms babies

New tool hunts for Alzheimer's clues in gut microbiome

Unveiling pancreatic mysteries: 3D imaging redefines islet cell distribution

Gut bacteria manipulation may offer a promising approach to managing inflammatory bowel disease

Liver cells effectively serve as immune checkpoint regulating anti-cancer immunity

Insightful review explores alcohol-related liver cancer pathogenesis

Engineered peptides show promise in cancer immunotherapy

Researchers receive NIH grant to help develop gene therapy for HIV

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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