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The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.

Researchers identify novel biomarkers in renal cell carcinomas

A new study led by University of Michigan Health Rogel Cancer Center researchers identifies novel biomarkers in renal cell carcinomas.

6 May 2024

Researchers identify key molecular alterations from endurance exercise that could combat chronic diseases

A whole-organism molecular map of the temporal effects of endurance training in rats.

3 May 2024

Protein profiling reveals impact of aging and resistance training on skeletal muscle proteome

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training."

2 May 2024

New drug candidate reverses obesity in mice by transforming liver metabolism

A mitochondrial transcription inhibitor (IMT) shifted metabolism in high-fat diet mice toward fatty acid oxidation, leading to weight loss, reduced liver fat, and improved glucose tolerance.

1 May 2024

Scientists map all yeast proteins across cell cycle for the first time

An international team led by researchers at the University of Toronto has mapped the movement of proteins encoded by the yeast genome throughout its cell cycle. This is the first time that all the proteins of an organism have been tracked across the cell cycle, which required a combination of deep learning and high-throughput microscopy.

23 Apr 2024

New trials show promise for immune checkpoint blockers in early-stage lung cancer

A dendritic cell (DC) vaccine targeting patient-specific neoantigens to patients with resected non-small cell lung cancer (NSCLC).

18 Apr 2024

Blood protein could be a potential biomarker for delayed concussion recovery in children

Researchers have discovered a blood protein that could help detect which children will experience ongoing concussion symptoms more than two weeks after an injury.

9 Apr 2024

Innovative molecular biology technique used to identify targets for Schistosoma mansoni vaccine candidates

Researchers in Brazil have used an innovative technique in molecular biology to identify targets for candidate vaccines against Schistosoma mansoni, the parasite that causes schistosomiasis.

2 Apr 2024

Scientists identify distinct molecular signatures for sepsis diagnosis and prognosis

Researchers from Lund University in Sweden have identified distinct molecular signatures associated with the clinical signs of sepsis that could provide more accurate diagnosis and prognosis of sepsis, as well as help to target specific therapies at patients who would benefit most, according to new research being presented at this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024) in Barcelona, Spain (27-30 April).

30 Mar 2024

Research offers first insights into the mechanism behind synaptic development

The first analysis of how synaptic proteins change during early development reveals differences between mice and marmosets but also what's different in individuals with autism spectrum disorders.

28 Mar 2024

Researchers create new platform to identify proteins for targeted treatment of disease

Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins -; a new but largely unrealized approach to the treatment of disease.

22 Mar 2024

Mapping the aging brain's protein landscape

Researchers at LMU and the SyNergy Cluster of Excellence have analyzed how the proteome of specific brain cells changes as we age.

22 Mar 2024

Proteotyping unveils new extremophiles in high-altitude lakes

Perfectly adapted microorganisms live in extreme environments from deep-sea trenches to mountaintops. Learning more about how these extremophiles survive in hostile conditions could inform scientists about life on Earth and potential life on other planets.

15 Mar 2024

Human molecular adaptations to fasting: Insights from proteomic analysis

Researchers investigate systemic proteome adaptations to one week of fasting in humans.

6 Mar 2024

Study reveals the body's molecular response to prolonged fasting

New findings reveal that the body undergoes significant, systematic changes across multiple organs during prolonged periods of fasting.

1 Mar 2024

Caffeine's protective effects against obesity and joint diseases supported by genetic study

The effects of caffeine levels in circulation by considering genetically predicted variations in caffeine metabolism.

28 Feb 2024

AI tool helps develop the most complete map of the bacterial essential interactome

Universitat Autonoma de Barcelona (UAB) researchers have produced the most complete map of the bacterial essential interactome, i.e. how proteins combine and interact to perform functions essential for their survival.

23 Feb 2024

Physical inactivity and inflammation drive age-related gene changes in skeletal muscles

New research indicates that some age-related changes in gene and protein expression in the skeletal muscles of older individuals may be affected more by physical inactivity and chronic inflammation than primary aging, or intrinsic maturational processes.

21 Feb 2024

Novel genetic associations with anxiety unveiled in comprehensive study of over 1.2 million people

The genetic basis of anxiety disorders, identify genetic loci, and calculate polygenic risk scores for anxiety.

20 Feb 2024

AI revolutionizes protein function prediction with "DeepGO-SE"

Researchers developed "DeepGO-SE," a novel AI method for predicting protein functions from sequences, significantly outperforming traditional models by incorporating gene ontology and protein-protein interactions.

15 Feb 2024