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Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

Scientists from J. Craig Venter Institute, Ludwig Institute for Cancer Research, and The Johns Hopkins University School of Medicine identified three novel mutations in two receptor tyrosine kinases in glioblastoma tumors using high throughput sequencing.

26 Sep 2005

No significant differences among different ethnic groups for breast cancer related to hormone replacement therapy

The study, published online September 16, 2005 in the International Journal of Cancer, the official journal of the International Union Against Cancer (UICC), did find that leaner women taking hormone replacement therapy had a relatively greater increase in breast cancer risks than heavier women.

26 Sep 2005

Polymorphisms in a receptor called CD32 influence the response to antibody therapy in cancer

In a paper appearing online in advance of print publication of the October 1 issue of the Journal of Clinical Investigation, Adam Boruchov and colleagues from Memorial Sloan Kettering Cancer Center dissect the contributions of CD32 isoforms in human dendritic cell (DC) activation and function.

26 Sep 2005

Low-dose aspirin might prevent the cardiovascular damage known to arise from use of the painkiller rofecoxib (Vioxx)

Their findings that a chemical imbalance might underlie such damage could also lead to the development of anti-inflammatory drugs without the adverse side effects, the researchers said.

20 Sep 2005

Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence

Using a recently developed mouse model of breast cancer, a team from the University of Pennsylvania School of Medicine has shown that Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence.

20 Sep 2005

Discovery that protein CD38 interrupts an interaction between the AIDS virus and its point of entry into cells

Cornell University researchers have discovered the 3-D crystal structure of a protein, human CD38, which may lead to important discoveries about how cells release calcium - a mineral used in almost every cellular process.

19 Sep 2005

Researchers detail molecular images of a piece of the spike-shaped protein that the SARS virus uses initiate the first stages of infection

Researchers have determined the first detailed molecular images of a piece of the spike-shaped protein that the SARS virus uses to grab host cells and initiate the first stages of infection.

19 Sep 2005

Drug AMD-3100 may help cancer patients who need stem cell transplants

A new drug may help cancer patients mobilize the cells necessary to restore their blood-forming system after high-dose chemotherapy, according to results from a clinical trial at the Kimmel Cancer Center at Thomas Jefferson University Hospital in Philadelphia and at other centers across the nation.

19 Sep 2005

Microtubules critical to development of mental disorders

Neuroscientists at the University at Buffalo have shown in two recently published papers that destabilization of structures called microtubules, intracellular highways that transport receptors to their working sites in the brain, likely underlie many mental disorders and could be promising targets for intervention.

12 Sep 2005

Translation elongation factor eEF1A2 is is a potential oncogene that is overexpressed in two-thirds of breast tumors

The tissue-specific elongation factor eEF1A2 might be an oncoprotein involved in breast cancer.

12 Sep 2005

Nuclear receptor proteins could change anti-inflammatory treatments

Several nuclear receptor proteins appear to overlap in their ability to exert anti-inflammatory effects, according to new research by scientists at the University of California, San Diego (UCSD).

12 Sep 2005

Genetic basis for susceptibility to alcohol abuse confirmed

A new set of experiments in mice confirms that a brain receptor associated with the reinforcing effects of marijuana also helps to stimulate the rewarding and pleasurable effects of alcohol.

12 Sep 2005

Why do estrogen-dependent breast-cancer cells grow and spread rapidly?

Researchers at the University of Illinois at Urbana-Champaign say it may be because estrogen virtually eliminates levels of a vitally important regulatory protein.

10 Sep 2005

Anorexia may be caused by change in brain chemical

A new study has found that women who have had a certain type of anorexia nervosa show a change in the activity of a chemical in their brain that is widely associated with anxiety and other affective disorders, for as long as one year after recovery.

7 Sep 2005

Letrozole following tamoxifen may benefit women with breast cancer

Switching to the drug letrozole following 5 years of treatment with tamoxifen reduces the risk of hormone-dependent breast cancer recurrence, but not overall survival, among postmenopausal women, according to a new study in the September 7 issue of the Journal of the National Cancer Institute.

7 Sep 2005

Part of largest randomised international trial program ever conducted in atrial fibrillation (AF) discontinued

Study treatments for the ACTIVE W trial of the ACTIVE (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events) program have been discontinued due to a significant difference in efficacy, in favour of the standard oral anticoagulation (OAC) over antiplatelet therapy (clopidogrel plus aspirin).

6 Sep 2005

Anorexia nervosa linked with alteration of the activity of serotonin in their brain

Women who have had a certain type of anorexia nervosa show an alteration of the activity of a chemical in their brain that is widely associated with anxiety and other affective disorders more than one year after recovery, according to a study in the September issue of Archives of General Psychiatry.

6 Sep 2005

Nurse-led multidisciplinary programme can help coronary patients and their families to reduce their risk of major cardiovascular disease

Early results from the EuroAction hospital project, announced today at the European Society of Cardiology, demonstrate how a nurse-led multidisciplinary programme, organised in busy general hospitals, can help coronary patients and their families to reduce their risk of major cardiovascular disease (CVD).

5 Sep 2005

Naturally occurring peptide hormones - candidates for the treatment of cancer, sexual dysfunction, eating disorders

Chemists at the University of Arizona have developed modified versions of naturally occurring peptide hormones that could be key to novel treatments of a variety of diseases, including eating disorders (anorexia, obesity), diabetes, sexual dysfunction and skin cancer.

1 Sep 2005

GenoMed has announced that it successfully treated its thirteenth patient with presumed West Nile virus encephalitis

The patient is a previously healthy man from Aberdeen, South Dakota who developed fever and headache and was diagnosed by his physician as having West Nile virus on Monday of this week. South Dakota has about 50 times higher incidence of West Nile virus this summer than California.

1 Sep 2005

Receptor News and Research

Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

No significant differences among different ethnic groups for breast cancer related to hormone replacement therapy

Polymorphisms in a receptor called CD32 influence the response to antibody therapy in cancer

Low-dose aspirin might prevent the cardiovascular damage known to arise from use of the painkiller rofecoxib (Vioxx)

Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence

Discovery that protein CD38 interrupts an interaction between the AIDS virus and its point of entry into cells

Researchers detail molecular images of a piece of the spike-shaped protein that the SARS virus uses initiate the first stages of infection

Drug AMD-3100 may help cancer patients who need stem cell transplants

Microtubules critical to development of mental disorders

Translation elongation factor eEF1A2 is is a potential oncogene that is overexpressed in two-thirds of breast tumors

Nuclear receptor proteins could change anti-inflammatory treatments

Genetic basis for susceptibility to alcohol abuse confirmed

Why do estrogen-dependent breast-cancer cells grow and spread rapidly?

Anorexia may be caused by change in brain chemical

Letrozole following tamoxifen may benefit women with breast cancer

Part of largest randomised international trial program ever conducted in atrial fibrillation (AF) discontinued

Anorexia nervosa linked with alteration of the activity of serotonin in their brain

Nurse-led multidisciplinary programme can help coronary patients and their families to reduce their risk of major cardiovascular disease

Naturally occurring peptide hormones - candidates for the treatment of cancer, sexual dysfunction, eating disorders

GenoMed has announced that it successfully treated its thirteenth patient with presumed West Nile virus encephalitis

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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