Receptor News and Research

RSS

Overactive dopamine receptors may help explain anorexia nervosa symptoms

Just why those with anorexia nervosa are driven to be excessively thin and seem unaware of the seriousness of their condition could be due to over-activity of a chemical system found in a region deep inside the brain, a University of Pittsburgh study suggests.

11 Jul 2005

New approach to preventing or reversing heart failure

Duke University Medical Center researchers have identified a new protein that plays a critical role in enabling the heart to respond to such external stimuli as exercise or stress, as well as in the progressive loss of heart function that is heart failure, the researchers said.

11 Jul 2005

Blood pressure enzyme linked to SARS virus, could help fight diseases that cause lung failure

Researchers in Austria say that an enzyme that regulates blood pressure is also involved in the SARS virus, and the discovery could lead to new ways of treating diseases that cause lung failure.

11 Jul 2005

Potential novel treatment targets for the most common form of childhood epilepsy

New research suggests novel treatment targets for the most common form of childhood epilepsy - with the potential to have fewer side effects than traditional therapy. The findings from Wake Forest University School of Medicine are reported in the July issue of the Journal of Neurophysiology.

6 Jul 2005

Study is the first to show that there are mechanisms in place for the immune system to identify cancer cells

A study undertaken by biologists at the University of California, Berkeley, has found that damage to a cell's DNA sets off a chain reaction that leads to the increased expression of a marker recognized by the body's immune system.

6 Jul 2005

New drug to treat stroke complications tested in US for the first time as part of an international trial

A Roanoke, Va. woman is the first U. S. participant in an international, multi center trial of a new drug that shows promise in treating complications from a stroke.

1 Jul 2005

Scientists discover identifying markers for primitive blood-forming stem cells - simplifies cell identification

Scientists at the University of Michigan Medical School have discovered the biological equivalent of a grocery store bar code on the surface of primitive, blood-forming stem cells in mice. Called hematopoietic stem cells, they give rise to all the different types of specialized cells found in blood.

30 Jun 2005

Major study says for diabetics with high blood pressure diuretics are the best option

A major new study has found that for people with type 2 diabetes and high blood pressure, cheaper diuretic medications may be the most cost-effective option in reducing hypertension.

29 Jun 2005

Diuretics work better than newer and more costly medicines for diabetics with high blood pressure

Diuretics (water pills) work better than newer and more costly medicines in the treatment of high blood pressure and prevention of some forms of heart disease in people with type 2 diabetes, according to results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

28 Jun 2005

Scientists have discovered how C-reactive protein is able to access endothelial cells

For the first time, scientists have discovered how C-reactive protein, or CRP, is able to access endothelial cells. The UC Davis researchers' findings will be published in the July issue of Arteriosclerosis, Thrombosis, and Vascular Biology, one of the American Heart Association's leading journals.

27 Jun 2005

Scientists solve structure of a critical innate immune system protein

Scientists at The Scripps Research Institute have solved the structure of a crucial human immune system molecule called TLR3, an acronym for Toll-like receptor three. In an upcoming issue of the journal Science, the protein is described as a large horseshoe-shaped coil composed of 23 leucine-rich repeats (LRRs).

27 Jun 2005

If you know how viruses get into cells, you know how to better design drugs to keep them out

When it comes to gaining entry into cells, size matters. A team from Brown University and the Max Planck Institute for Metals Research has created a model that explains how viruses and other bioparticles slip inside cells without a special protein coating called clathrin.

27 Jun 2005

OHSU scientists say low FOXP3 means fewer disease-fighting cells, but new drug may help multiple sclerosis

Oregon Health & Science University researchers have measured genetic changes reflecting a drop in the body's ability to suppress inflammatory cells that attack nerve fibers and promote progression of multiple sclerosis.

27 Jun 2005

Researchers demonstrate direct transfer of terminally differentiated cell nuclei

With the advent of nuclear-transfer cloning, it is now possible to produce mice from the nuclei of differentiated cells, such as peripheral blood lymphocytes and olfactory sensory neurons.

20 Jun 2005

Study shows why thiazolidinediones cause edema and helps understand role of kidneys in hypertension

In related discoveries with far-reaching implications for treating diabetes and understanding hypertension, University of Utah researchers have learned why thiazolidinediones (TZDs), a major anti-diabetes drug, cause edema and also have found a new pathway critical to fluid metabolism. Identification of this pathway may help understand fundamental mechanisms of blood pressure control.

19 Jun 2005

Chronic insomnia medicines have not yet been rigorously evaluated for long-term use

Many of the medications widely used to manage chronic insomnia have not yet been rigorously evaluated for long-term use, according to an independent scientific panel convened this week by the National Institutes of Health.

16 Jun 2005

Neurocrine Biosciences issued new U.S. patent

Neurocrine Biosciences announced today the issuance of U.S. Patent No. 6,903,106 covering a novel polymorphic form (different crystal structure) of its proprietary compound indiplon for the treatment of insomnia.

16 Jun 2005

Nicotine triggers the same neural pathways that give opiates their addictively rewarding properties

In experiments with mice, researchers have found that nicotine triggers the same neural pathways that give opiates such as heroin their addictively rewarding properties--including associating an environment with the drug's reward.

15 Jun 2005

Study examines biomarkers for response to erlotinib in glioma

Researchers have found two biomarkers that, in patients with a malignant type of brain tumor called glioblastoma multiforme, were associated with response to the cancer drug erlotinib (Tarceva).

14 Jun 2005

Chemokine Therapeutics granted new U.S patent

Chemokine Therapeutics has announced that it has been granted U.S. Patent No. 6,875,738 relating to the use of its anti-cancer compound, CTCE-9908, in the treatment of cancer and inhibition of angiogenesis. CTCE-9908 is designed to block CXCR4, a receptor found on the surface of cancer cells.

14 Jun 2005

Receptor News and Research

Overactive dopamine receptors may help explain anorexia nervosa symptoms

New approach to preventing or reversing heart failure

Blood pressure enzyme linked to SARS virus, could help fight diseases that cause lung failure

Potential novel treatment targets for the most common form of childhood epilepsy

Study is the first to show that there are mechanisms in place for the immune system to identify cancer cells

New drug to treat stroke complications tested in US for the first time as part of an international trial

Scientists discover identifying markers for primitive blood-forming stem cells - simplifies cell identification

Major study says for diabetics with high blood pressure diuretics are the best option

Diuretics work better than newer and more costly medicines for diabetics with high blood pressure

Scientists have discovered how C-reactive protein is able to access endothelial cells

Scientists solve structure of a critical innate immune system protein

If you know how viruses get into cells, you know how to better design drugs to keep them out

OHSU scientists say low FOXP3 means fewer disease-fighting cells, but new drug may help multiple sclerosis

Researchers demonstrate direct transfer of terminally differentiated cell nuclei

Study shows why thiazolidinediones cause edema and helps understand role of kidneys in hypertension

Chronic insomnia medicines have not yet been rigorously evaluated for long-term use

Neurocrine Biosciences issued new U.S. patent

Nicotine triggers the same neural pathways that give opiates their addictively rewarding properties

Study examines biomarkers for response to erlotinib in glioma

Chemokine Therapeutics granted new U.S patent

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

Latest News