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Novel therapeutic approach identified for overcoming resistance in B-cell leukemia

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%.

8 Apr 2024

Lerodalcibep reduces LDL cholesterol by over 50% in high-risk patients

Among patients at high or very high risk for a heart attack or stroke, the addition of the investigational drug lerodalcibep to standard cholesterol-lowering medication for one year reduced LDL, or "bad" cholesterol, levels by more than half on average, compared with a placebo.

8 Apr 2024

Language model uses powers of semantic representation to design more effective mRNA vaccines

The same class of artificial intelligence that made headlines coding software and passing the bar exam has learned to read a different kind of text -; the genetic code.

5 Apr 2024

New method to evaluate enzymes opens path to ferroptosis-targeting cancer drugs

New research could pave the way to develop cancer drugs targeting an enzyme that inhibits ferroptosis, a type of cell death.

5 Apr 2024

Lancet Commission predicts sharp increase in global prostate cancer cases

Cases of prostate cancer are projected to double from 1.4 million per year in 2020 to 2.9 million per year by 2040, with low- and middle-income countries (LMICs) predicted to see the highest increases in cases, according to The Lancet Commission on prostate cancer which will be launched by a presentation at the European Association of Urology Congress.

4 Apr 2024

Using brain organoids to unlock TBI's link to dementia and ALS

A traumatic brain injury (TBI) can quadruple your risk for developing dementia and increase your chances of developing neurodegenerative diseases such as ALS.

4 Apr 2024

Understanding T. cruzi infection and Chagas disease through studies in dogs

Announcing a new article publication for Zoonoses journal. Trypanosoma cruzi, the protozoan parasite and cause of Chagas disease, is widely distributed in many vertebrate and triatomine species throughout North, Central, and South America.

4 Apr 2024

Innovative approach to disrupt misfolding of tau proteins in neurodegenerative diseases

A spectrum of neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are due to the accumulation of abnormal, misfolded tau proteins in the brain.

3 Apr 2024

Lurie Children's Hospital administers first gene therapy for Duchenne muscular dystrophy in Illinois

On March 27, 2024, Ann & Robert H. Lurie Children's Hospital of Chicago treated its first patient with ELEVIDYS (delandistrogene moxeparvovec-rokl), the first gene therapy for Duchenne muscular dystrophy – a rare, genetic disease characterized by progressive muscle damage and weakness.

3 Apr 2024

Certain gut bacteria may help lower cholesterol and heart disease risk

Changes in the gut microbiome have been implicated in a range of diseases including type 2 diabetes, obesity, and inflammatory bowel disease.

2 Apr 2024

New technique reveals insights into gut cell dynamics during inflammation

Cells within the intestines perform various roles including nutrient absorption, sensing, and maintaining homeostasis.

2 Apr 2024

An ActRIIA fusion protein got FDA approved for PAH treatment

On March 26th, the US FDA granted approval for Merck’s WINREVAIR™ (sotatercept-csrk), marking a significant milestone in pulmonary arterial hypertension (PAH) treatment. PAH, characterized by elevated blood pressure in the arteries connecting the heart and lungs, poses a grave risk of heart failure.

From Sino Biological Inc. 28 Mar 2024

Therapeutics News and Research

Novel therapeutic approach identified for overcoming resistance in B-cell leukemia

Lerodalcibep reduces LDL cholesterol by over 50% in high-risk patients

Language model uses powers of semantic representation to design more effective mRNA vaccines

New method to evaluate enzymes opens path to ferroptosis-targeting cancer drugs

Lancet Commission predicts sharp increase in global prostate cancer cases

Using brain organoids to unlock TBI's link to dementia and ALS

Understanding T. cruzi infection and Chagas disease through studies in dogs

Innovative approach to disrupt misfolding of tau proteins in neurodegenerative diseases

Lurie Children's Hospital administers first gene therapy for Duchenne muscular dystrophy in Illinois

Certain gut bacteria may help lower cholesterol and heart disease risk

New technique reveals insights into gut cell dynamics during inflammation

An ActRIIA fusion protein got FDA approved for PAH treatment

Study reveals crucial insights into the ocular effects of Zika virus infection during pregnancy

Unraveling gene regulation's role in pulmonary fibrosis

Xenotransplantation model used for studying microglial response to Alzheimer's disease

Breakthrough study offers hope for an effective HIV cure

Teva UK and Closed Loop Medicine announce strategic partnership to advance development of personalised medicines

Ubiquigent and Debiopharm enter agreement to support USP1 inhibitor programme for Debio 0432

C-Path announces formation of new task force to foster drug development for Progressive Supranuclear Palsy

New glycan found to play a key role in nasal colonization of whooping cough bacteria

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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