Ubiquitin News and Research

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Ubiquitin is a small regulatory protein that has been found in almost all cells (''ubiquitously'') with nuclei (eukaryotes). It directs proteins to recycling and other functions.

Molecular pathology of Schaaf-Yang syndrome: Insights into MAGEL2 gene mutations and truncated proteins

Mutations in the MAGEL2 gene, which cause Schaaf-Yan syndrome (SYS) —an ultra-rare disease that affects neuronal and cognitive development— generate truncated, non-functional proteins that tend to accumulate in the cell nucleus.

8 May 2024

Protein profiling reveals impact of aging and resistance training on skeletal muscle proteome

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training."

2 May 2024

Study links agricultural pesticide exposure to increased genetic variants in Parkinson’s disease

Genetic characteristics that influence the risk of Parkinson's disease (PD) due to pesticide exposure.

1 May 2024

ZIP7: A novel target for treating degenerative diseases associated with misfolded proteins

Proteins are the workhorses of life. Organisms use them as building blocks, receptors, processors, couriers and catalysts.

30 Apr 2024

Sino Biological finalizes the acquisition of SignalChem Biotech, strengthening global presence and expanding product portfolio

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From Sino Biological Inc. 29 Apr 2024

Insilico Medicine's AI-designed drug ISM3412 receives FDA IND approval

Clinical stage artificial intelligence (AI)-driven drug discovery company Insilico Medicine announces that it has received approval from the U.S. Food and Drug Administration for its Investigational New Drug application for ISM3412, a small molecule inhibitor of MAT2A for the potential treatment of MTAP deleted cancers designed with Insilico's generative AI platform.

25 Apr 2024

Researchers create new platform to identify proteins for targeted treatment of disease

Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins -; a new but largely unrealized approach to the treatment of disease.

22 Mar 2024

Clay Wright awarded prestigious MIRA funding for engineering common cellular signals

Clay Wright, assistant professor in the College of Agriculture and Life Sciences' Department of Biological Systems Engineering, was awarded a prestigious Maximizing Investigators' Research Award from the National Institute of General Medical Sciences, part of the National Institutes of Health.

14 Mar 2024

Discovery of new organelle could improve the understanding of chronic liver diseases

Scientists have identified a new organelle in liver cells called the mitochondria-lysosome-related organelle (MLRO).

12 Mar 2024

Ubiquigent enters agreement with Astellas subsidiary, Nanna Therapeutics

Agreement leverages Ubiquigent’s DUB-focused drug discovery platform to support the development of novel therapeutic candidates for multiple disease targets selected by Nanna Therapeutics.

From Ubiquigent Limited 11 Mar 2024

Unveiling the molecular mechanism responsible for crossover interference during meiosis

Movies such as 'X-Men,' 'Fantastic Four,' and 'The Guardians,' which showcase vibrant mutant heroes, have captivated global audiences.

7 Mar 2024

UCLA researchers uncover dual role of GAN gene in neurological disorder, head and neck cancer

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center show for the first time that a gene usually linked to giant axonal neuropathy, a rare and severe neurological condition, also plays a role in inhibiting aggressive tumor cell growth in head and neck cancers.

29 Feb 2024

Ubiquitin News and Research

Further Reading

Molecular pathology of Schaaf-Yang syndrome: Insights into MAGEL2 gene mutations and truncated proteins

Protein profiling reveals impact of aging and resistance training on skeletal muscle proteome

Study links agricultural pesticide exposure to increased genetic variants in Parkinson’s disease

ZIP7: A novel target for treating degenerative diseases associated with misfolded proteins

Sino Biological finalizes the acquisition of SignalChem Biotech, strengthening global presence and expanding product portfolio

Insilico Medicine's AI-designed drug ISM3412 receives FDA IND approval

Researchers create new platform to identify proteins for targeted treatment of disease

Clay Wright awarded prestigious MIRA funding for engineering common cellular signals

Discovery of new organelle could improve the understanding of chronic liver diseases

Ubiquigent enters agreement with Astellas subsidiary, Nanna Therapeutics

Unveiling the molecular mechanism responsible for crossover interference during meiosis

UCLA researchers uncover dual role of GAN gene in neurological disorder, head and neck cancer

EPFL scientists uncover protein degradation mechanism preventing autoimmune reactions

Unlocking coronavirus structure through M protein research

New study defines clinical phenotype of Post-infectious ME/CFS, highlighting unique biomarker insights

Intramolecular bivalent glues: A promising avenue for protein degradation

Molecular glue could pave the way for new generation of drugs

Study uncovers critical roles for USP1 in Ewing sarcoma

NEMO protein's crucial role in Parkinson's defense revealed

OHSU study sheds light on ubiquitin modification during bacterial infection

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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