Senomyx prices common stock offering at $2.80 per share

Senomyx, Inc. (NASDAQ: SNMX) announced today the pricing of an underwritten public offering of 7,142,857 shares of its common stock at a price to the public of $2.80 per share. The gross proceeds from the sale of the shares, before underwriting discounts and commissions and other offering expenses, are expected to be approximately $20.0 million. The offering is expected to close on or about February 18, 2010, subject to customary closing conditions. Senomyx has also granted the underwriters a 30-day option to purchase up to an aggregate of 1,071,428 additional shares of common stock to cover over-allotments, if any. All of the shares in the offering are being sold by Senomyx.

Senomyx anticipates using the net proceeds from the offering to fund research and development efforts, and for general corporate purposes, including working capital.

Deutsche Bank Securities Inc. is acting as sole book-running manager for the offering. Needham & Company, LLC and Roth Capital Partners, LLC are acting as co-managers of the offering. A copy of the final prospectus supplement and accompanying prospectus relating to the offering, when available, may be obtained for free by visiting EDGAR on the SEC website at www.sec.gov or by contacting Deutsche Bank Securities Inc., Attention: Prospectus Department, 100 Plaza One, Jersey City, New Jersey 07311, Telephone number: (800) 503-4611, Email: [email protected].

A shelf registration statement relating to the shares was filed with the Securities and Exchange Commission and is effective.

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