Advanced endoscope to enable rapid, accurate diagnosis of early colon cancer

Minimally invasive endoscope using breakthrough photonics technology to enable rapid, accurate diagnosis of bowel polyps and early colon cancer.

Funded under Horizon 2020, the EU's research and innovation program, a European group of scientists are working on the development of an innovative, compact and easy to use endoscopic device, which will play a crucial role in identifying and diagnosing pre-cancerous polyps and early colon cancers. Worldwide, colon cancer remains the third most common cancer in men, behind lung and prostate cancer, and second in women, behind breast cancer.

Colorectal cancer ranks as one of the world's most predominant cancers, affecting approximately one in ten people during their life and causing almost 700,000 annual deaths globally. Almost 95% of these cases are adenocarcinomas, which typically start as a growth of tissue called a polyp.

Today, the main method to achieve early detection of the disease is colonoscopy. While up to 40% of the patients under routine analysis colonoscopy present one or more polyps, almost 30% of these polyps are not detected, especially in the case of flat polyps. Of those detected, 29-42% are generally hyperplastic, and will not develop into cancer. The remainder are neoplastic polyps, which are of primary importance because they harbor malignant potential and represent a stage in the development of colorectal cancer. For this reason, it is essential to identify these polyps at an early stage.

Speaking about the PICCOLO Project Dr. Artzai Picon (Tecnalia) said "We hope that PICCOLO will provide major benefits over traditional colonoscopy. Firstly, by developing an advanced endoscope, using both Optical Coherence Tomography (OCT)  & Multi-Photon Tomography (MPT), we will provide high-resolution structural and functional imaging, giving details of the changes occurring at the cellular level comparable to those obtained using traditional histological techniques. Furthermore, when multiple polyps are detected in a patient, the current gold standard procedure is to remove all of them, followed by microscopic tissue analysis. Removal of hyperplastic polyps, which carry no malignant potential, and the subsequent costly histolopathological analysis might be avoided through the use of the PICCOLO endoscope probe, which could allow image-based diagnosis without the need for tissue biopsies".

The long term potential for this project is exciting. Not only will it provide a new approach in colon cancer detection, but the new image based diagnosis methods could be applied to diseases in other organs of the body.  The PICCOLO team hope to have refined their first prototype by the end of 2018 and targets clinical trials to begin around 2020.