Sepsis News and Research

Latest Sepsis News and Research

Cause and clinical outcome of portal vein thrombosis

Among the 118 patients with portal vein thrombosis, noncirrhotic and nontumoral extrahepatic portal vein obstruction are young and present with well tolerated bleed.

15 Oct 2007

First high-res 3D structures of first mammalian GRP94 protein solved

Dr. Dan Gewirth, Hauptman-Woodward senior research scientist, has just solved the structure of the first mammalian GRP94 protein implicated in immune diseases such as sepsis, AIDS and certain cancers.

15 Oct 2007

Over 60's do well after liver transplantation

Patients who undergo liver transplantation at age 60 or above have 1-year and 5-year survival rates similar to those of younger patients and they experience fewer episodes of rejection.

3 Oct 2007

Potential new therapy for uveitis

An inflammatory eye condition that is one of the world's leading causes of blindness could be treated much more effectively and easily thanks to a new discovery here.

29 Sep 2007

Acute lung injury patients one-third less likely to die in 'closed' model ICUs

Patients with acute lung injury (ALI) are nearly one-third less likely to die if they are treated at ICUs that require board-certified critical care physicians to oversee patient care, as compared to patients treated at ICUs that allow any attending physician to oversee admission and case management.

29 Sep 2007

Care by a hospital-based general physician strongly associated with shorter length of hospital stay in patients

Patients at an academic medical center who are cared for by a hospital-based general physician may have a shorter length of hospital stay than those who are not, especially if the patients require close monitoring or complex discharge planning, according to a report in the September 24 issue of Archives of Internal Medicine.

25 Sep 2007

HSP 90 inhibitors may help ICU patients beat infections

HSP 90 inhibitors, which are finding favor in fighting cancer, may also help battle overwhelming infection in intensive care patients, researchers say.

28 Aug 2007

Study looks at large burns

Large burns can trigger cardiac problems and enhanced inflammatory and hypermetabolic responses in patients, a study in the online open access journal Critical Care suggests.

24 Aug 2007

Surgical options for severe intra-abdominal inflammation

Performing a repeat surgery for patients with peritonitis (severe intra-abdominal inflammation or infection) only when clinical improvement is lacking may have some advantages compared with having the repeat procedure routinely scheduled after the operation, according to a study in the August 22/29 issue of JAMA.

22 Aug 2007

Researchers discover how a protein modulates the inflammatory response in acute respiratory distress syndrome

Researchers at the University of Illinois at Chicago College of Medicine have discovered how a protein modulates the inflammatory response in sudden, life-threatening lung failure.

17 Aug 2007

Researchers discover how Bcl-3 protein stops inflammation

Researchers at the University of Pennsylvania School of Medicine recently identified how a regulatory protein called Bcl-3 helps to control the body's inflammation response to infection by interfering a critical biochemical process called ubiquitination.

12 Aug 2007

Bcl-3 protein regulates inflammation by blocking ubiquitination

8 Aug 2007

Potential biomarker to predict acute kidney injury earlier than current tests

Clinicians currently lack advance warning of acute kidney injury (AKI) for patients where kidney injury timing is unknown.

3 Aug 2007

Ethnic differences in the risk of neonatal mortality and morbidity

Researchers have uncovered ethnic differences in the risk of neonatal mortality and morbidity (disease) in the neonatal intensive care units (NICU).

24 Jul 2007

Venous thromboembolism in the U.S.

Venous thrombosis (VTE), the formation of blood clots in a vein, is a major health problem for hospitalized patients in the United States.

16 Jul 2007

New method to estimate sickle cell disease severity

Researchers from Boston University School of Medicine (BUSM) and Boston University School of Public Health (BUSPH) have developed a method to estimate sickle cell disease severity and predict the risk of death in people with this disease.

12 Jul 2007

Protein C levels help predict severity of illness and risk of death in ICU patients

A simple laboratory test to measure protein C - a natural anti-blood-clotting substance that also reflects the level of inflammation in the body - may offer a useful new indicator of the severity of illness and risk of death among critically ill patients.

26 Jun 2007

Patients with an alcohol-use disorder are more likely to require mechanical ventilation

More than 300,000 patients receive mechanical ventilation during intensive care per year in the United States, even though the hospital mortality rate for ventilated patients can approach 50 percent.

26 Jun 2007

Study on B-cell depletion therapy

36% of patients with refractory systemic lupus erythematosus (SLE or lupus) remain well after undergoing B-cell depletion therapy (BCDT) without needing further standard immunosuppressive agents, according to a study presented at EULAR 2007, the Annual European Congress of Rheumatology in Barcelona, Spain.

17 Jun 2007

New mathematical model of sepsis

A new mathematical model of sepsis can help predict deaths, discharges, and disease progression in hospital patients with this serious bacterial blood infection. It's hoped the model, described in the online open access journal Critical Care, will help clinicians assess which interventions are likely to be best for their patients.

17 Jun 2007