Sepsis News and Research

Latest Sepsis News and Research

Method by which Caspase-12 shuts down the body's immune system discovered

Caspase-12 is a molecule with a death-wish. Found only in people of African descent, this protein shuts down our body's immune system, opening the door to potentially lethal infections. In a groundbreaking new study published in the prestigious journal Nature this week, the team that first discovered the role of caspase-12 in humans has now uncovered the mechanism by which it sabotages us, allowing researchers to develop methods to counter its damaging effects.

28 Apr 2006

Caspase-12 antagonists could potentially be useful in the treatment of sepsis and other inflammatory and immune disorders

According to the new study, the presence of caspase-12, which appears to modulate inflammation and innate immunity in humans, increases the body's "vulnerability to bacterial infection and septic shock" while a deficiency confers strong resistance to sepsis. This new discovery suggests that caspase-12 antagonists could be a potentially useful in the treatment of sepsis and other inflammatory and immune disorders.

26 Apr 2006

Corticosteroids do not improve survival in patients with late-stage acute respiratory distress syndrome

The study is the first multi-center randomized clinical trial to evaluate the effects of moderate doses of steroids in ARDS patients when treatment is started 7 days or more after the onset of the condition.

20 Apr 2006

FDA investigates abortion pill death

It seems that since the FDA approved the use of the abortion pill RU-486, (Mifeprex/ mifepristone) in September 2000, six women in the U.S. have died.

12 Apr 2006

Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C

Cirrhosis related to non-alcoholic steatohepatitis (NASH) is associated with fewer complications and a lower mortality compared to cirrhosis from hepatitis C, despite NASH patients' greater risk of dying from cardiovascular events.

11 Apr 2006

Streptococcal toxic shock syndrome caused by Streptococcus suis Serotype 2

Last year, there was major press coverage of an alarmingly large and deadly outbreak of Streptococcus suis disease in Sichuan province in China.

11 Apr 2006

Nrf2 gene findings may offer therapeutic potential for sepsis treatment

Disruption of a single gene, Nrf2, plays a critical role in regulating the body's innate immune response to sepsis and septic shock, according to a study by a research team led by Shyam Biswal, PhD, at the Johns Hopkins Bloomberg School of Public Health.

4 Apr 2006

Hospitalized schizophrenics more likely to have complications

A Johns Hopkins study of more than 1,700 patients with schizophrenia hospitalized for medical or surgical care unrelated to their mental disorder shows they are at least twice as likely as similar patients without schizophrenia to suffer dangerous and expensive adverse events.

15 Mar 2006

Breakthrough in fast, disposable DNA testing

Thermal Gradient announced today that it has successfully developed a 30-cycle PCR device that can amplify DNA in just 4.4 minutes, far faster than anything available in the marketplace.

9 Mar 2006

Breakthrough anti-inflammatory treatment

Scientists from the Garvan Institute of Medical Research have developed what could be the next big blockbuster treatment for inflammatory diseases such as rheumatoid arthritis and asthma.

21 Feb 2006

Drug abuse linked to brain hemmorhage in young adults

A fifth of young adults whose blood vessels ruptured inside their brain abused drugs and more than 40 percent had malformed blood vessels, according to a study reported Feb. 17 at the American Stroke Association's International Stroke Conference 2006 in Kissimmee, FL.

20 Feb 2006

Topical anaesthesia and morphine effective in treating procedural pain in newborn infants

Researchers at The Hospital for Sick Children (SickKids) have found that intravenous morphine used alone or with a topical anaesthetic (tetracaine) effectively reduced levels of pain in newborn infants undergoing insertion of central venous catheters (central lines).

17 Feb 2006

Less is more hypothesis - gene loss may explain unique human traits

Humans and chimps share most of their genes, yet they differ dramatically in many ways - their walk, the sizes of their brains and their capacities for speech and language, for example.

16 Feb 2006

Gut protein protects against infection and intestinal breakdown

A protein that binds to bile in the small intestine may hold the key to preventing infection and intestinal breakdown in people with conditions such as obstructive jaundice or irritable bowel syndrome, researchers at UT Southwestern Medical Center have discovered.

12 Feb 2006

Researchers define a new "first step" that initiates sepsis

A Mayo Clinic research team has challenged the accepted theory on the cause of sepsis -- a condition in which the body's cells generate fever, shock and often death. Sepsis is thought to occur when poisons from bacterial infection interfere with the cells.

9 Feb 2006

Patients checking into a top rated hospital have a 27 percent lower chance of mortality

Patients checking into a hospital rated in the top five percent in the country have, on average, a 27 percent lower chance of mortality and a 14 percent lower risk of complications, according to a study released today by HealthGrades, the leading independent healthcare ratings company.

7 Feb 2006

Statins cut the risk of serious infection

According to scientists Cholesterol-lowering drugs, known as statins, can reduce the risk of severe infection in patients suffering from heart disease or stroke.

26 Jan 2006

Fundamental flaws in many medical studies must be fixed in order to catch signs of harm

Only by analyzing results using a statistical method that considers several factors at once -- for instance, overall heart attack risk, rather than just individual risk factors such as age -- will researchers truly be able to see how the risks and benefits of a treatment vary from patient to patient, the study suggests.

14 Nov 2005

HIV-positive patients have shorter survival periods while awaiting liver transplants

A new study on HIV-positive patients eligible for liver transplants found that their survival while waiting for a transplant is significantly shorter than patients who are HIV-negative.

7 Nov 2005

New fungal defensin, plectasin, possesses as much power as penicillin

A peptide identified in a fungus found in northern European pine forests possesses as much power as penicillin as well as vancomycin, according to an international team of researchers.

12 Oct 2005