Sepsis News and Research

Latest Sepsis News and Research

Increasingly virulent Staph infections

In a "Brief Report" in the 22 September 2005 issue of the New England Journal of Medicine, researchers at the University of Chicago describe three cases of rapidly progressive and ultimately fatal Staphylococcus aureus infections in small children.

26 Sep 2005

Adult sickle cell drug hydroxyurea proves effective in young children

A drug used for the treatment of sickle cell anemia in adults has now been shown to cause significant improvements in very young children with the disorder.

20 Sep 2005

More than 15 percent of our genes are mobilized to defend against microbial attacks

The body's overwhelming genetic defense, which has implications for the survival of patients who are severely burned or injured, was revealed in a sweeping analysis of gene activity in volunteers who were injected with a bacterial product that temporarily created flu-like symptoms.

1 Sep 2005

When it comes to inflammation, too much of a good thing can be deadly

In some severely injured patients, this normal healing process can develop into a lethal, whole-body response, including bloodstream infection (sepsis) and multiple organ failure. How and why inflammation turns from healing to harming is still mysterious, so doctors can't accurately predict how each injured patient will fare.

31 Aug 2005

Pseudomonas aeruginosa has broken the immune system's code

The human opportunistic pathogen, Pseudomonas aeruginosa, has broken the immune system's code, report researchers from the University of Chicago, enabling the bacteria to recognize when its host is most vulnerable and to launch an attack before the weakened host can muster its defenses.

1 Aug 2005

Blood pressure enzyme linked to SARS virus, could help fight diseases that cause lung failure

Researchers in Austria say that an enzyme that regulates blood pressure is also involved in the SARS virus, and the discovery could lead to new ways of treating diseases that cause lung failure.

11 Jul 2005

HIF-1alpha expression regulates the bactericidal capacity of phagocytes

When microorganisms invade the body, immune mechanisms kick in to fight them off. The infected tissues typically show depleted oxygen levels, and a protein called HIF-1 alpha regulates this. Interestingly, the cells responsible for destroying the foreign pathogens are effective in this low-oxygen environment.

6 Jul 2005

$5.1 billion could save 6 million children

Six million children could be saved if $5.1 billion in new resources for preventive and therapeutic interventions were provided each year, according to researchers from the Johns Hopkins Bloomberg School of Public Health and other institutions.

27 Jun 2005

FDA approves Xeloda (capecitabine) oral chemotherapy

Roche announced today that the U.S. Food and Drug Administration (FDA) has approved Xeloda (capecitabine) -- an innovative oral chemotherapy -- for the adjuvant (post-surgery) treatment of patients with Dukes' C colon cancer.

15 Jun 2005

Competition from specialty hospitals promotes high-quality patient care

Specialty hospitals provide quality care to patients by offering new choices, and this hospital competition should not be stifled, the American Medical Association (AMA) testified to a subcommittee of the Senate Committee on Homeland Security and Governmental Affairs this week.

26 May 2005

Anti-inflammatory protein annexin 1 may protect patients from the detrimental effects of severe inflammatory response syndrome

Severe inflammatory response syndrome, or SIRS, occurs when the body's response to an overwhelming infection becomes uncontrolled. The very immune response meant to clear the pathogen and its toxins actually causes damage to the host's own tissues when it goes into overdrive, releasing too many immune signals.

23 May 2005

Breast cancer chemotherapy regimen associated with life-threatening complications

The chemotherapy regimen of doxorubicin plus docetaxel, used to treat breast cancer in a clinical trial, was associated with an increased risk of serious complications, resulting in the premature termination of the trial, according to a study in the May 18 issue of JAMA.

17 May 2005

Parents of new born convicted of reckless homicide

A newborn baby girl died unnecessarily because her parents rejected medical intervention for their ailing daughter.

15 May 2005

Molecular switch may help fight off MRSA

The discovery of a 'molecular switch' could lead to new ways of treating infections such as MRSA, and inflammatory diseases like arthritis.

27 Apr 2005

Community MRSA is re-emergence of 1950's pandemic

This "re-equipping and re-emergence" of a clone that caused a pandemic 40-50 years ago could mean that community acquired MRSA will spread faster and be more widespread than previously expected, warns an international team of researchers who have been studying the bacteria.

3 Apr 2005

Vaccine prevents deadly pneumonia in African children

Global health leaders today presented new research showing that vaccinating infants against Streptococcus pneumoniae -- a bacterium that causes deadly pneumonia, meningitis and sepsis -- could substantially reduce death and serious illness among children in the developing world. If used widely, a pneumococcal conjugate vaccine could prevent hundreds of thousands of child deaths each year.

28 Mar 2005

New estimates of the causes of child mortality worldwide

Seventy-three percent of the 10.6 million child deaths worldwide each year are the result of six causes: pneumonia, diarrhea, malaria, neonatal sepsis, preterm delivery and asphyxia at birth.

28 Mar 2005

Most accurate estimates of the causes of child deaths to date

The most accurate estimates of the causes of child deaths to date, published in this week’s issue of The Lancet, reveal that worldwide more than 70% of the 10·6 million child deaths that occur annually are attributable to six causes: pneumonia (19%), diarrhoea (18%), malaria (8%), neonatal sepsis or pneumonia (10%), preterm delivery (10%), and asphyxia at birth (8%).

28 Mar 2005

Invasive pneumonia and antibiotic resistance decreased after childhood streptococcus pneumoniae vaccine introduced

The problem of increasing antibiotic resistance in cases of Streptococcus pneumoniae, a major cause of pneumonia, meningitis and sepsis, was dramatically reversed following the licensing and use of a new conjugate vaccine for young children in February 2000, according to research conducted at Emory University, the Atlanta Veterans Affairs Medical Center, the Centers for Disease Control and Prevention, and the Georgia Division of Public Health.

21 Mar 2005

Discovery may provide a new target to treat sepsis

Part of the immune system's pro-inflammatory response to bacterial invasion is to increase nitric oxide levels with an enzyme called inducible nitric oxide synthase.

14 Mar 2005