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Tumors use enzyme to recruit regulatory T-cells and suppress immune response

One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, researchers say.

17 Aug 2007

We need to treat cancer like an infectious disease

Among the many medical miracles produced by science over the years, vaccines and antibiotics have undoubtedly saved the most lives.

17 Aug 2007

Cannabis for allergic contact dermatitis

Administering a substance found in the cannabis plant can help the body's natural protective system alleviate an allergic skin disease (allergic contact dermatitis), an international group of researchers from Germany, Israel, Italy, Switzerland and the U.S. has found.

17 Aug 2007

New understanding of how HSV-1 attacks cells

A team of University of Kentucky researchers has identified the roles that herpes simplex virus type 1 (HSV-1) proteins play during the invasion of cells and the formation of skin lesions known as cold sores and fever blisters.

17 Aug 2007

Reactivating a critical gene lost in kidney cancer reduces tumor growth

Researchers at Mayo Clinic Jacksonville, have found that a key gene is often silenced in clear cell renal cell carcinoma, the most common type of kidney cancer, and when they restored that gene in human kidney cancer cells in culture and animal experiments, tumors stopped growing and many disappeared.

17 Aug 2007

Prophylactic cranial irradiation in small cell lung cancer significantly increases survival

Prophylactic cranial irradiation after chemotherapy significantly reduces the risk of brain metastasis and doubles one-year survival in small-cell lung cancer (SCLC), according to the results of the multicenter phase III randomized EORTC trial 08993-22993, published in the New England Journal of Medicine.

17 Aug 2007

Pronouns light up brain!

New research suggests that pronouns may play a far greater role than simply replacing a proper name in a sentence. A University of South Carolina study suggests that pronouns help keep the brain's complex circuitry and limited memory system from being overloaded.

17 Aug 2007

Organ-transplant drug may help fight lupus

A compound related to a drug used in humans to prevent organ-transplant rejection attacks a key biochemical process in the faulty immune cells of lupus-prone mice, suggesting a possible new approach to combating the disease, UT Southwestern Medical Center researchers have found.

17 Aug 2007

PET MPI provides a more accurate "picture" of coronary obstruction

Physicians need to know how badly heart vessels are blocked before they can decide how to treat patients at risk of having a heart attack.

17 Aug 2007

Obesity and aversion to exercise could enhance the risk of pancreatic cancer

Obesity and aversion to exercise have become hallmarks of modern society and a new study suggests that a blood protein linked to these lifestyle factors may be an indicator for an increased risk of developing pancreatic cancer.

17 Aug 2007

New prion protein 'Shadoo' discovered - may offer insight into mad cow disease

Scientists have discovered a new protein that may offer fresh insights into brain function in mad cow disease.

17 Aug 2007

Sirtuin protein instrumental in fat production and metabolism

A new Joslin Diabetes Center-led study has identified a protein found in fat cells that may play a major role in how fat is produced and stored, offering a new target for treatments to prevent obesity and reduce the risk for type 2 diabetes.

17 Aug 2007

Most flu shot plans do not address how to vaccinate hard-to-reach populations

Most flu immunization plans in the United States do not address how to vaccinate hard-to-reach populations (HTR)--undocumented immigrants, substance users, the homeless, homebound elderly, and minorities--and this potentially dangerous omission can lead masses of people to become ill during an outbreak of pandemic flu or other contagious disease, according to a new study by the New York Academy of Medicine in the current issue of the Journal of Urban Health.

17 Aug 2007

Mice use specialized neurons to detect carbon dioxide in the air

For mice, carbon dioxide often means danger - too many animals breathing in too small a space or a hungry predator exhaling nearby.

17 Aug 2007

Scientists describe a new way of creating novel enzymes

The intricate interplay of proteins and other chemicals that underlies most biological activities requires the participation of enzymes, specialized molecules that accelerate chemical reactions between molecules.

17 Aug 2007

New food allergy law in New York

The Food Allergy Initiative (FAI) has announced that Governor Eliot Spitzer has signed into law the Allergy & Anaphylaxis Management Act of 2007 (AAMA; A.4051), landmark legislation that will help protect New York schoolchildren who suffer from life-threatening food allergies.

17 Aug 2007