Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Pulmospheres could serve as personalized, predictive model for assessing effect of IPF drugs

Pulmospheres, three dimensional multicellular spheroids composed of lung cells from individual patients, were shown to be effective in predicting the efficacy of medications for idiopathic pulmonary fibrosis, according to findings from University of Alabama at Birmingham scientists presented today in JCI Insight, a journal of the American Society for Clinical Investigation.

27 Jan 2017

TSRI researchers develop first stable semisynthetic single-celled organism

Life’s genetic code has only ever contained four natural bases. These bases pair up to form two “base pairs”—the rungs of the DNA ladder—and they have simply been rearranged to create bacteria and butterflies, penguins and people. Four bases make up all life as we know it.

25 Jan 2017

Chemists show that synthetic nanoparticles can achieve structural complexity of biomolecules

Chemists at Carnegie Mellon University have demonstrated that synthetic nanoparticles can achieve the same level of structural complexity, hierarchy and accuracy as their natural counterparts - biomolecules.

24 Jan 2017

Researchers find new way to quantify olfactory sensory neurons using PET radiotracer

Olfactory health - how well we are able to smell - is a reliable marker of the health of the brain, but the "smell identification tests" commonly used in studies of olfactory health do not offer a complete picture of what is happening.

24 Jan 2017

TSRI scientists develop new method to enhance drug discovery and protein research

A team led by scientists at The Scripps Research Institute (TSRI) has developed a versatile new method that should enhance the discovery of new drugs and the study of proteins.

20 Jan 2017

Protein aggregation may trigger inflammatory response linked to neurodegenerative diseases

A recent review article published online in The FASEB Journal points to the "trigger" for the inflammatory response, caused by the immune system, that precedes Alzheimer's disease and other neurological conditions.

11 Jan 2017

TSRI scientists develop new tool to uncover molecular details of protein structure

Scientists on the Florida campus of The Scripps Research Institute have developed a new tool for studying the molecular details of protein structure.

5 Jan 2017

UTA chemists developing new synthetic methods to produce compounds for drug discovery

Chemists at The University of Texas at Arlington are developing new methods to synthesize groups of chemical compounds to provide faster, less expensive routes to produce the compounds for subsequent use in medical drug discovery and development.

4 Jan 2017

FDA grants permission to assess safety of investigational drug for Alzheimer's disease in humans

Vanderbilt University scientists have received notification from the U.S. Food and Drug Administration that testing in humans may proceed for an investigational new drug for Alzheimer's disease after more than 10 years of research by scientists at Vanderbilt University and Vanderbilt University Medical Center.

28 Dec 2016

Ionis announces FDA approval of first SMA drug in the U.S for pediatric and adult patients

Ionis Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration has approved SPINRAZATM (nusinersen) under Priority Review for the treatment of spinal muscular atrophy (SMA) in pediatric and adult patients.

26 Dec 2016

Blocking protein that initiates immune response against viral infections may help combat HIV

In findings they call counterintuitive, a team of UCLA-led researchers suggests that blocking a protein, which is crucial to initiating the immune response against viral infections, may actually help combat HIV.

23 Dec 2016

Generative AAE can be radically new way to discover drugs on demand

Scientists at the Pharmaceutical Artificial Intelligence group of Insilico Medicine, Inc, today announced the publication of a seminal paper demonstrating the application of generative adversarial autoencoders (AAEs) to generating new molecular fingerprints on demand.

22 Dec 2016

TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Scientists from the Florida campus of The Scripps Research Institute have developed an efficient process to rapidly discover new “enediyne natural products” from soil microbes that could be further developed into extremely potent anticancer drugs.

22 Dec 2016

Hamilton Storage launches new SAM HD for reliable, automated sample management in labs

Hamilton Storage is proud to introduce the new SAM HD, a low-capacity automated sample management system. SAM HD is the reliable, walkaway solution for labs seeking to transition from manual to automated sample storage.

From Hamilton Process Analytics 22 Dec 2016

Mount Sinai researchers laying groundwork to find effective treatment for Zika virus

Researchers at the Icahn School of Medicine at Mount Sinai are working on the basic science that lays the groundwork to finding a way to treat and prevent the Zika virus, a global health risk.

22 Dec 2016

UNC scientists develop new tool to study G-protein signaling

Scientists from the UNC School of Medicine have developed a new tool for studying a key process in cells called G-protein signaling, which plays a central role in the normal functioning of cells and can go awry to cause severe disease, including cancers.

22 Dec 2016

Researcher develops new method to accurately identify elusive molecules

Among the most important molecules in the living world are sugars or carbohydrates, which play a vital role in life processes. Sugars provide the main source of fuel for the body, protect muscles from damage and contribute to the immune response.

21 Dec 2016

TSRI scientist receives Outstanding Investigator Grant to focus on memory formation research

Ron Davis, chair of the Department of Neuroscience on the Florida campus of The Scripps Research Institute has been awarded a $5 million Outstanding Investigator Grant, one of the first of its kind, by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health.

20 Dec 2016

Scientists discover mechanism that hijacks immune system's response to tuberculosis

Scientists have discovered the mechanism that hijacks the immune system's response to tuberculosis, revealing an important new drug target for the disease that kills more than 1 million people each year.

17 Dec 2016

Recipient of the Pittsburgh Conference Achievement Award announced by Pittcon

The Pittcon Program Committee is pleased to announce this year’s recipients of 15 prestigious awards honoring scientists who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each award will be presented in a scheduled symposium during Pittcon, the world’s leading conference and exposition for laboratory science, March 5-9, Chicago, Illinois, McCormick Place West Hall.

From Pittcon 16 Dec 2016

Drug Discovery News and Research

Further Reading

Pulmospheres could serve as personalized, predictive model for assessing effect of IPF drugs

TSRI researchers develop first stable semisynthetic single-celled organism

Chemists show that synthetic nanoparticles can achieve structural complexity of biomolecules

Researchers find new way to quantify olfactory sensory neurons using PET radiotracer

TSRI scientists develop new method to enhance drug discovery and protein research

Protein aggregation may trigger inflammatory response linked to neurodegenerative diseases

TSRI scientists develop new tool to uncover molecular details of protein structure

UTA chemists developing new synthetic methods to produce compounds for drug discovery

FDA grants permission to assess safety of investigational drug for Alzheimer's disease in humans

Ionis announces FDA approval of first SMA drug in the U.S for pediatric and adult patients

Blocking protein that initiates immune response against viral infections may help combat HIV

Generative AAE can be radically new way to discover drugs on demand

TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Hamilton Storage launches new SAM HD for reliable, automated sample management in labs

Mount Sinai researchers laying groundwork to find effective treatment for Zika virus

UNC scientists develop new tool to study G-protein signaling

Researcher develops new method to accurately identify elusive molecules

TSRI scientist receives Outstanding Investigator Grant to focus on memory formation research

Scientists discover mechanism that hijacks immune system's response to tuberculosis

Recipient of the Pittsburgh Conference Achievement Award announced by Pittcon

eBook: Essential guide to organoids in drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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