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FoxOs shown to be potential new targets for cancer drugs

In an elegant, multiple-gene knockout experiment, a team of Boston scientists has discovered that a trio of molecules, called FoxOs, are fundamentally critical in preventing some cancers, maintaining blood vessel stability, and in keeping blood-forming stem cells healthy.

29 Jan 2007

SH2B1 protein plays a key role in controlling body weight, response to insulin and leptin

A single protein in brain cells may act as a linchpin in the body's weight-regulating system, playing a key role in the flurry of signals that govern fat storage, sugar use, energy balance and weight, University of Michigan Medical School researchers report.

29 Jan 2007

China softens on one-child policy

Zhang Weiqing, head of China's National Population and Family Planning Commission, announced that the government will reduce fines for low-income couples who violate the country's one-child-per-family policy, the Washington Post reports (Fan, Washington Post, 1/24).

28 Jan 2007

One-fifth of women in India experience menopause by age 41

About one in five women residing in India are likely to experience menopause by the age of 41, according to a study conducted by Bangalore, India-based Institute for Social and Economic Change, London's Times reports.

28 Jan 2007

North American Menopause Society releases guidelines saying HRT beneficial for younger women

The North American Menopause Society on Thursday released a revised position statement that said the benefits of short-term hormone replacement therapy for treatment of menopausal women likely outweigh the risks for younger women, the Wall Street Journal reports.

28 Jan 2007

Thailand plans to break antiretroviral patents

Thai Public Health Minister Mongkol Songkhla plans to break patents on an antiretroviral drug and a drug for heart disease by issuing compulsory licenses to produce lower-cost versions, Ministry of Public Health spokesperson Suphan Srithamma announced on Thursday, AFP/Yahoo! News reports.

28 Jan 2007

A plasminogen-activating protease specifically controls the development of primary pneumonic plague

The deadly attack of the bacterium that causes pneumonic plague is significantly slowed when it can't make use of a key protein, scientists at Washington University School of Medicine in St. Louis report in Science.

28 Jan 2007

Molecular mechanism behind aggregation of amyloid beta peptide due to anesthetics

Inhaled anesthetics commonly used in surgery are more likely to cause the aggregation of Alzheimer's disease-related plaques in the brain than intravenous anesthetics say University of Pittsburgh School of Medicine researchers in a journal article published in Biochemistry.

28 Jan 2007

New tool to detect depression in cancer patients

A tool to detect depression in cancer patients launched by the University of Liverpool will vastly improve patients' ability to come to terms with their disease.

28 Jan 2007

RNA used to turn on genes to alleviate disease

A new technique that employs RNA, a tiny chemical cousin of DNA, to turn on genes could lead to therapeutics for conditions in which nudging a gene awake would help alleviate disease, researchers at UT Southwestern Medical Center say.

28 Jan 2007

Alternative to artery-clogging trans fats

Alejandro's research group found a way to mix oil, water, monoglycerides and fatty acids to form a gel substance that provides the same structural and functional benefits as trans and saturated fats.

28 Jan 2007

Linemen more than twice as likely as other players to have metabolic syndrome

After retirement, National Football League (NFL) linemen - generally the heaviest players - are more than twice as likely as other players to have a syndrome that puts them at risk for heart disease, stroke and other cardiovascular diseases

28 Jan 2007

Link between MRI contrast agent and nephrogenic systemic fibrosis

New research has shown a possible association between a popular magnetic resonance imaging (MRI) contrast agent and the incidence of a rare disease called nephrogenic systemic fibrosis (NSF) in patients with kidney disease, according to an editorial appearing in the March issue of Radiology.

28 Jan 2007

Micro molecules can distinguish pancreatic cancer from normal and benign pancreatic tissue

The study examined human pancreatic tumor tissue and compared it to nearby normal tissue and control tissue for levels of microRNA (miRNA).

28 Jan 2007

Minor mistake in protein production at the cellular level may lead to serious neurological diseases

But exactly how the cell avoids such mistakes has remained unclear until now. Researchers at Ohio State University found the mechanism that prevents such errors, and explain their findings in the Proceedings of the National Academy of Sciences.

28 Jan 2007

Study sheds light on complex design of tears

It's no secret why we shed tears. But exactly what our tears are made of has remained a mystery to scientists.

28 Jan 2007

Brown seaweed may provide protective ingredient against skin cancers

Substances extracted from a marine seaweed may protect against skin cancer caused by too much sun, new research suggests.

28 Jan 2007

Healthy 4 year-olds who eat lots of fat weigh less

Four-year-olds eat too few vegetables and too much sugar. They also bolt down lots of junk food, but children who eat more fat than others nevertheless weigh less. This is shown in a new dissertation from the Sahlgrenska Academy at Goteborg University in Sweden.

28 Jan 2007

Manipulation of proliferation and differentiation of human bone marrow derived neural stem cells in vitro and in vivo

Stem cells taken from adult human bone marrow have been manipulated by scientists at the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center to generate aggregates of cells called spheres that are similar to those derived from neural stem cells of the brain.

28 Jan 2007

Disorderly protein brings order to cell division

The secret to the ability of a molecule critical for cell division to throw off the protein yoke that restrains its activity is the yoke itself a disorderly molecule that seems to have a mind of its own, say investigators at St. Jude Children's Research Hospital, Innsbruck Medical University and Max Planck Institute.

28 Jan 2007