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Researchers step closer to cure for common childhood cancer

Acute lymphoblastic leukemia (ALL) is a malignant disease caused by the abnormal growth and development of white blood cells (WBC) in the bone marrow and blood. ALL is the most common cancer occurring in children with an annual rate of approximately 30 to 40 new cases per million.

5 Dec 2004

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Telik, Inc. reported positive interim data from a Phase 2 trial of its Telintra (TLK199) drug candidate in myelodysplastic syndrome (MDS). The data were reported in two presentations at the annual meeting of the American Society of Hematology in San Diego.

5 Dec 2004

Single dose phase I data on CG53135 for the prevention of oral mucositis

CuraGen Corporation has announced results presented from a Phase I clinical trial with CG53135 for the prevention of oral mucositis (OM) in patients receiving high dose chemotherapy (HDCT) followed by autologous hematopoietic stem cell transplantation (AHSCT) at the ASH 46th Annual Meeting in San Diego, CA.

5 Dec 2004

Phase 3 results of Genasense plus Dexamethasone in patients with advanced multiple myeloma

Genta Incorporated announced that results from the Company's randomized Phase 3 clinical trial of Genasense(R) (oblimersen sodium) Injection in patients with relapsed or refractory multiple myeloma were presented today at the annual meeting of the American Society of Hematology (ASH) in San Diego, CA.

4 Dec 2004

Novel anti-obesity compound shows promise for treatment of obesity

Arena Pharmaceuticals announced today results from the dosing phase of its Phase 1b clinical trial of APD356, an orally administered small molecule designed to regulate satiety (and perhaps metabolism) for the treatment of obesity.

30 Nov 2004

Potential vaccine for the deadly toxin ricin

A potential vaccine for the deadly toxin ricin, a "Category B" biological agent, will enter the first phase of clinical testing in coming weeks at UT Southwestern Medical Center at Dallas.

30 Nov 2004

Viral Genetics announces effects of VGV-1 in antiretroviral non-responding HIV infections

Viral Genetics announced today that the results of a clinical trial of its investigational therapy for HIV infection, VGV-1, were recently published in a peer reviewed journal, HIV & AIDS Review.

29 Nov 2004

New trial to test cancer smart drugs

Cancer Research UK has launched a major new clinical trial for the most common form of lung cancer, to test the effectiveness of one of the new generation of 'smart' cancer drugs as a first line treatment.

29 Nov 2004

Drug combination of amodiaquine and sulfadoxinepyrimethamine might offer the optimal treatment for malaria

Results of a randomised trial from Uganda in this week’s issue of THE LANCET suggest that the drug combination of amodiaquine and sulfadoxinepyrimethamine might offer the optimal treatment for malaria in terms of efficacy and cost-effectiveness in this region.

29 Nov 2004

FDA approval of Tysabri, for the treatment of multiple sclerosis

Biogen and Elan Corporation have announced that the U.S. Food and Drug Administration (FDA) has approved Tysabri (natalizumab), as treatment for relapsing forms of multiple sclerosis (MS) to reduce the frequency of clinical relapses.

24 Nov 2004

FDA approves Tarceva (erlotinib)

OSI Pharmaceuticals and Genentech have announced that the U.S. Food and Drug Administration (FDA) has approved, after priority review, Tarceva (erlotinib) for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) after failure of at least one prior chemotherapy regimen.

20 Nov 2004

Premature infants with lung disease may continue to require replacement substance to ease breathing

Physicians have known for decades that many premature babies suffer respiratory problems stemming from insufficiency of a lung substance called surfactant during their first few weeks of life.

20 Nov 2004

Transcranial Magnetic Stimulation to treat major depression

Psychiatrists at Rush University Medical Center are testing a noninvasive technique that uses repeated short bursts of magnetic energy to stimulate nerve cells in the brain to treat major depression.

20 Nov 2004

Prolonged abstinence, no visual problems in patients taking GVG for meth/cocaine abuse

A second, small clinical trial of a proposed addiction treatment led by investigators at NYU School of Medicine and the U.S. Department of Energy's Brookhaven National Laboratory has produced favorable results in the treatment of long-term addiction to methamphetamine and/or cocaine, with no visual side effects in any of the 30 patients enrolled.

18 Nov 2004

Biotoxin from puffer fish may provide treatment for opioid withdrawal

On November 10, 2004 investigators involved in a Phase IIa clinical trial of the novel biotoxin Tetrodotoxin (TTX) for the treatment of opioid withdrawal enrolled their first participants.

18 Nov 2004

70% of cases of spina bifida are preventable by folic-acid supplementation

A seminar in this week’s issue of THE LANCET discusses the causes, symptoms, and treatments relating to spina bifida, and reinforces an important public-health message for women about to become pregnant

18 Nov 2004

Researchers find effective treatment for Unusual Fever Syndrome caused by cold exposure

Remember when Grandma used to say, "don’t go out in the cold; you’ll get sick”? It turns out that she was right for a small number of people who have a condition called familial cold autoinflammatory syndrome (FCAS)

16 Nov 2004

Vegetables such as cabbage, broccoli, sprouts or cauliflower could help in the fight against cancer

Researchers from the Wales College Of Medicine, Cardiff University in the UK have discovered what may be a clue to the prevention and treatment of cancer. They have found that when vegetables such as cabbage, broccoli, sprouts or cauliflower are eaten, they could help in the fight against cancer.

16 Nov 2004

Vasogen announces full patient enrollment in its trial of Celacade in peripheral arterial disease

Vasogen today announced that it has reached full enrollment in its 500-patient pivotal phase III SIMPADICO trial of Celacade (immune modulation therapy) for the treatment of peripheral arterial disease (PAD).

16 Nov 2004

36% of cancer patients ages 65 and older participate in clinical trials

A new study finds that only 36% of cancer patients ages 65 and older participate in clinical trials, despite making up 60% of the U.S. cancer population. The study will be published November 15 in the Journal of Clinical Oncology (JCO).

14 Nov 2004

Clinical Trial News and Research

Researchers step closer to cure for common childhood cancer

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Single dose phase I data on CG53135 for the prevention of oral mucositis

Phase 3 results of Genasense plus Dexamethasone in patients with advanced multiple myeloma

Novel anti-obesity compound shows promise for treatment of obesity

Potential vaccine for the deadly toxin ricin

Viral Genetics announces effects of VGV-1 in antiretroviral non-responding HIV infections

New trial to test cancer smart drugs

Drug combination of amodiaquine and sulfadoxinepyrimethamine might offer the optimal treatment for malaria

FDA approval of Tysabri, for the treatment of multiple sclerosis

FDA approves Tarceva (erlotinib)

Premature infants with lung disease may continue to require replacement substance to ease breathing

Transcranial Magnetic Stimulation to treat major depression

Prolonged abstinence, no visual problems in patients taking GVG for meth/cocaine abuse

Biotoxin from puffer fish may provide treatment for opioid withdrawal

70% of cases of spina bifida are preventable by folic-acid supplementation

Researchers find effective treatment for Unusual Fever Syndrome caused by cold exposure

Vegetables such as cabbage, broccoli, sprouts or cauliflower could help in the fight against cancer

Vasogen announces full patient enrollment in its trial of Celacade in peripheral arterial disease

36% of cancer patients ages 65 and older participate in clinical trials

eBook: Using iPSCs models for human disease research and drug discovery eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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