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Scientists create leaner and meaner E. coli

By stripping the E. coli genome of vast tracts of its genetic material - hundreds of apparently inconsequential genes - a team of Wisconsin researchers has created a leaner and meaner version of the bacterium that is a workhorse of modern biology and industry.

3 May 2006

Current US drug safety system is moving toward a delay in drug approval

In the May 3 issue of the Journal of the American Medical Association, Brian L. Strom, MD, MPH, Professor of Public Health and Preventive Medicine and Chair of the Department of Biostatistics and Epidemiology at the University of Pennsylvania School of Medicine, analyzes the limitations of the current system of drug-safety monitoring and proposes a solution that addresses overly aggressive early marketing practices

3 May 2006

Link between perceived neighborhood safety and BMI

Mothers of young children are more likely to be obese when they perceive their neighborhoods as unsafe, according to a new study in the journal Obesity.

3 May 2006

New study describes molecular basis of NeuroAIDS

Using multi-disciplinary analysis that included cognitive, neurophysiologic, virologic, and molecular techniques, the team found both a low-level viral infection in the brain and immune cells that had infiltrated the brain in order to protect against the virus.

3 May 2006

Analysis of 'virginity pledges'

Adolescents who sign a "virginity pledge" and then go on to have premarital sex are likely to disavow having signed such a pledge

3 May 2006

Periodontitis and plasma C-reactive protein during pregnancy

Researchers found that pregnant women with periodontitis had 65 percent higher C-reactive protein (CRP) levels compared to periodontally healthy women.

3 May 2006

New drug lixivaptan reduces excess fluid build-up in patients with congestive heart failure

Researchers believe they may have identified a new agent to reduce the excess fluid build-up in patients with congestive heart failure, one that avoids the relative sodium-depleting effects of diuretics, now the most commonly used drugs for this purpose.

3 May 2006

Obesity in the U.S. greatly underestimated

Researchers at the Harvard School of Public Health (HSPH) analyzed data from health surveys, which are used to estimate obesity levels in states. Because people tend to provide incorrect information about their weight and height, especially in telephone surveys, the researchers concluded that estimates of obesity in individual states have been too low, by more than 50%.

3 May 2006

Researchers recommend national uniform newborn screening tests

In a new study, conducted for the federal government and published in a supplement to the May issue of the journal Pediatrics, Stephen M. Downs, M.D. and Aaron E. Carroll, M.D., of the Indiana University School of Medicine, recommend a national uniform panel of newborn screening tests which they found to be cost saving as well as life saving.

3 May 2006

Etanercept and chemo might reduce fatigue in cancer patients

Researchers here have found evidence that combining a drug typically used to treat rheumatoid arthritis with chemotherapy might help reduce fatigue and muscle wasting that often afflicts cancer patients.

3 May 2006

Study looks at the cellular basis for immune activation in fatigued breast cancer survivors

Breast cancer survivors who suffer from persistent, debilitating fatigue years after their diagnosis have something in common: their immune systems don't shut down following treatment, according to researchers at UCLA's Jonsson Cancer Center.

3 May 2006

Comprehensive analysis of the human and mouse transcriptomes

An international consortium of scientists, including a team from The University of Queensland's Institute for Molecular Bioscience (IMB), is a step closer to the next generation of treatments to combat disease, after publishing a comprehensive analysis of the human and mouse transcriptomes.

3 May 2006

Men find masculine men more threatening during their partner's ovulation phase

Men become more jealous of dominant males when their female partner is near ovulation, researchers at the University of Liverpool have found.

3 May 2006

Cellular events leading to chondrocyte death after cartilage impact injury

Documented in extensive studies, backed by the anecdotal evidence of professional athletes, impact injury to joints causes degeneration of cartilage.

3 May 2006

Study highlights the benefits of a clinic that specializes in the needs of obese patients with metabolic syndrome

Obesity researchers at the Medical College of Wisconsin in Milwaukee found that a multidisciplinary clinical approach to caring for obese patients with metabolic syndrome could swiftly and significantly lower their risk for heart disease.

3 May 2006

Simple formula that will enable anesthesiologists to predict blood needs in heart surgery

Duke University Medical Center researchers have developed a simple formula that will enable anesthesiologists to predict, based on individual patient characteristics, how much blood to have on hand in the operating room prior to coronary artery bypass surgery.

3 May 2006

New vaccine against lethal avian influenza virus shows promise

A commercially developed vaccine has successfully protected mice and ferrets against a highly lethal avian influenza virus, according to the investigator who led the study at St. Jude Children's Research Hospital.

3 May 2006

Combined pharmacotherapies and behavioral interventions for alcohol dependence

While many treatment approaches were found helpful, the authors report that the patients who were most successful in abstaining from alcohol 16 weeks after treatment were those prescribed naltrexone under medical management and those participating in a multi-session program of alcohol counseling delivered by a behavioral specialist.

3 May 2006

Polymer-based therapy for breast cancer

Women who undergo surgery for breast cancer followed by radiation therapy often experience breast deformities that can only be corrected through reconstructive surgery.

3 May 2006