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Potential vaccine for visceral leishmaniasis developed

Development of a fundamentally new "candidate," or potential, vaccine for visceral leishmaniasis (LEASH-ma-NIGH-a-sis), a parasitic disease that kills about 60,000 people annually, is reported in the current issue of ACS Chemical Biology. Spread by the bite of infected female sand flies, visceral leishmaniasis infects about 500,000 people annually, with the majority of cases occurring in India, Bangladesh, Nepal, Sudan and Brazil.

26 Apr 2006

New Hybrid virus may aid treatment of cancer

Researchers at The University of Texas M. D. Anderson Cancer Center have created a new class of hybrid virus and demonstrated its ability to find, highlight, and deliver genes to tumors in mice.

26 Apr 2006

Evidence explains relationship between television and poor diet in children

Researchers from the Harvard School of Public Health (HSPH) and Children's Hospital Boston found that kids who spend more time watching television also eat more of the calorie-dense, low-nutrient foods advertised on television. Previous studies had demonstrated that children who watch more television are more likely to be overweight, but this is the first time a research team has found evidence for a mechanism explaining that relationship.

26 Apr 2006

Caspase-12 antagonists could potentially be useful in the treatment of sepsis and other inflammatory and immune disorders

According to the new study, the presence of caspase-12, which appears to modulate inflammation and innate immunity in humans, increases the body's "vulnerability to bacterial infection and septic shock" while a deficiency confers strong resistance to sepsis. This new discovery suggests that caspase-12 antagonists could be a potentially useful in the treatment of sepsis and other inflammatory and immune disorders.

26 Apr 2006

Friends and family can protect against Alzheimer's disease

Having close friends and staying in contact with family members offers a protective effect against the damaging effects of Alzheimer's disease according to research by physicians at Rush University Medical Center in Chicago. The study, which is currently posted online in The Lancet Neurology, will be published in the May print edition of the journal.

26 Apr 2006

Researchers identify characteristics that may lead to alcoholism

Those who are male and have behavioral disinhibition have the highest risk of developing alcoholism. Also, individuals with a family history of alcoholism (FH+) have a greater risk of developing alcoholism themselves than do persons with no family history, while FH+ individuals who are male and have behavioral disinhibition may have the greatest risk of developing alcoholism. Researchers caution that these combined characteristics indicate a greater probability, not certainty, of developing alcoholism.

26 Apr 2006

European flu pandemic plans show gaps and inconsistencies

A report reveals marked discrepancies in pandemic preparedness across Europe. The authors conclude that further planning and implementation is needed so that governments can effectively respond in the event of a pandemic, recommending action by the European Union to ensure governments work together towards a coordinated approach.

26 Apr 2006

Four subtypes of blood cancer identified

Scientists at Dana-Farber Cancer Institute and collaborators have identified four distinct genetic subtypes of multiple myeloma, a deadly blood cancer, that have different prognoses and might be treated most effectively with drugs specifically targeted to those subtypes.

26 Apr 2006

Medical adhesive may be produced from the strongest glue found in nature

A bacterium that lives in rivers, streams and human aqueducts uses nature's strongest glue to stay in one place. The bacterium could be mass produced and used to coat surfaces for medical and engineering purposes.

26 Apr 2006

Prefrontal cortex in the brain damaged by both alcoholism and chronic smoking

Alcoholism is commonly associated with chronic smoking, and both alcohol and nicotine are believed to act on the same brain region. Research builds upon previous research that identified four potential alcohol-sensitive genes in the prefrontal cortex, finding that smoking also influences the expression of these genes.

26 Apr 2006

Blood pressure readings lower if patients are allowed to relax and be comfortable

According to a new study from a team of nurses headed by Melly Turner, R.N., systolic blood pressure can be an average of 14 points higher when taken immediately after arriving in the exam room and sitting on an examination table rather than sitting in a chair with your back supported and feet flat on the floor. In fact, all study participants had lower systolic and diastolic blood pressure measurements when seated in a chair versus the exam table.

26 Apr 2006

Avian flu vaccine to be developed by Mount Sinai School of Medicine and Bionostra

The Mount Sinai School of Medicine will collaborate with the prestigious Bionostra Group of Spain to develop an avian flu vaccine. The vaccine will protect against the lethal infection of the H5N1 virus.

26 Apr 2006

Cause and treatment for aggressive head and neck cancer may have been found

Researchers report that they have found a potential molecular cause for the aggressive growth and spread of human head and neck squamous cell carcinoma, a highly malignant form of cancer with a very high death rate.

26 Apr 2006

Vegan diets more enivronmentally friendly than meat based diets

The food that people eat is just as important as what kind of cars they drive when it comes to creating the greenhouse-gas emissions that many scientists have linked to global warming, according to a report accepted for publication in the journal Earth Interactions.

26 Apr 2006

Blood cancers may be caused by inactivation of a "tumor suppressor" gene

The discovery of a gene, called PRDM1, as a tumor suppressor sheds new light on the cause - and possible treatment - of diffuse large B-cell lymphomas (DLBCLs), a cancer of the blood's B-lymphocytes. DLBCLs comprise about 30 percent of non-Hodgkin's lymphomas.

25 Apr 2006

Transplanted human tissue linked to seven cases of Creutzfeldt-Jakob disease in the UK

Seven cases of Creutzfeldt-Jakob disease (CJD) associated with transplanted human tissue have occurred in the UK over a period of 33 years, reveals a study published ahead of print in the Journal of Neurology Neurosurgery and Psychiatry.

25 Apr 2006

Prenatal exposure to alcohol can change child's circadian rhythms

Altered sleeping and eating patterns, behavioral problems, attention deficits and depression in children with fetal alcohol spectrum disorders may indicate that their biological rhythms, which are controlled by circadian systems, have been affected by alcohol exposure during development.

25 Apr 2006

Doctors show concern over rising preterm births

Doctors in the BMJ have expressed concern over the apparent increase in preterm births. The concerns are based on research showing that preterm deliveries increased by 22% from 1995 to 2004. Even among low risk women aged 20-40, there was a 51% increase in early delivery.

25 Apr 2006

'Resonance' may be the reason for virologic failure in STI drug therapy

Researchers have been puzzled over why HIV-positive patients who have periodic, built in interruptions in their drug therapy reach a point where the therapy no longer reduces their viral loads, even in the absence of any evidence of acquired drug resistance.

25 Apr 2006