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FDA recommends approval of the investigational anti-HIV drug tipranavir

Boehringer Ingelheim today announced that the U.S. Food and Drug Administration's (FDA) Antiviral Drugs Advisory Committee recommended the approval of the investigational anti-HIV drug tipranavir (11-3). Tipranavir is a non-peptidic protease inhibitor that requires boosting with low-dose ritonavir and must be used in combination with other antiretroviral agents.

20 May 2005

Study holds implications for gene therapy and stem cell biology

The study, conducted by scientists from Cincinnati Children's Hospital Medical Center, and Hannover Medical School and Hamburg University in Germany, reveals important evidence that tells us more about how blood forming stem cells regenerate. On the other hand, scientists offer caution in regards to the side effects associated with genetic engineering of stem cells.

20 May 2005

Physiotherapy is effective in treating stress incontinence

Physiotherapy is effective in treating stress incontinence in about 80 per cent of cases, according to the first national study undertaken in clinical practice by researchers at the University of South Australia.

20 May 2005

Judges perceive child witnesses as being more honest than adults when testifying in court

The multi-disciplinary research, the first of its kind to examine judges' perceptions of child witnesses, was led by Queen's Child and Family Law scholar Nick Bala. It addresses how judges assess the honesty and reliability of children's court testimony, and how accurate their observations are.

20 May 2005

Nurture as important as nature in developing ability for flexible self-control

Your ability to follow the rules of the road when driving on unfamiliar streets exists thanks to the way your pre-teen life experiences influenced the development of your brain. Individuals deprived of normal life experiences may lack this ability to control their behavior in novel situations, a new computer model suggests, providing insight into how nature and nurture may interact in the development of self-control.

20 May 2005

Merck cervical cancer virus vaccine performs well

Drugmaker Merck & Co. Inc. on Thursday said its investigational vaccine against a sexually transmitted virus linked to cervical cancer triggered a stronger immune response in young adolescents than in young women in a late-stage trial.

20 May 2005

So you thought that smell was cheese!

Researchers in the UK have found that visual words can influence the perception of smells, with pleasant words influencing olfactory brain regions to perceive an odour as pleasant, an interesting idea that might hold particular relevance for restaurateurs and advertisers.

20 May 2005

Extolling the safety of childhood vaccinations may only serve to strengthen the positions of those philosophically opposed to them

"Changing attitudes about pediatric vaccination can be challenging," says Dr. Kumanan Wilson, professor of medicine and health policy, management and evaluation at U of T, internal medicine physician at Toronto General Hospital, University Health Network, and lead author of the research.

20 May 2005

Drug used to treat enlarged prostate may improve the accuracy of prostate biopsies

The drug, dutasteride, suppresses blood flow in benign tissue of the prostate, allowing radiologists to better target cancer tissue using Doppler ultrasound, said Elizabeth Ives, MD, a research fellow at Thomas Jefferson University Hospital in Philadelphia and lead author of the study.

20 May 2005

Cetuximab (Erbitux) can battle cancer and prolong life in many patients with advanced colorectal cancer

"Even in people who have gone through six or more previous courses of chemotherapy, cetuximab, may fight the growth of cancer, giving patients additional months of life," says study presenter Heinz-Josef Lenz, M.D., associate professor of medicine at the Keck School of Medicine of the University of Southern California and USC/Norris Comprehensive Cancer Center.

20 May 2005

Cystatin-C, a new blood test for kidney function, is a better predictor of death and cardiovascular risk among the elderly

Investigators for NHLBI's Cardiovascular Health Study compared the two measures of kidney function, cystatin-C and the standard test creatinine, as predictors of death from all causes, death from cardiovascular causes, and incidence of heart attack and stroke among 4,637 elderly participants in the study.

20 May 2005

Studies on Hormone Replacement Therapy (HRT) for breast cancer patients can give false hopes

Women treated for breast cancer who are considering taking Hormone Replacement Therapy (HRT) should be cautious when using published research to inform their decision. An article published today in the journal Breast Cancer Research reveals that qualitative studies on the recurrence of breast cancer in breast cancer survivors undergoing HRT are unreliable.

20 May 2005

Sigmoidoscopy comes up short for women in detection of polyps in the colon

A new multi-center study has reaffirmed the difference between the sexes – at least when it comes to colorectal cancer detection and prevention.

20 May 2005

New kidney test better elder mortality predictor

A study at the San Francisco VA Medical Center (SFVAMC) has found that a test of kidney function that measures blood levels of cystatin C -- a protein produced by most cells in the body -- is a far more accurate predictor of mortality risk in elderly people than the current standard kidney function test, which measures levels of the protein creatinine.

20 May 2005

Bacteria in plaque may increase risk for heart attacks

Researchers have found evidence that the amount of bacteria in subgingival plaques, the deep plaques in periodontal pockets and around the teeth, may contribute to an individual's risk of a heart attack, according to two studies appearing the Journal of Periodontology.

20 May 2005

Narcotic medications can safely and effectively ease severe, chronic pain in older people

Narcotic medications can safely and effectively ease severe, chronic pain in older people with little risk that these patients will seek ever-increasing doses, University of California, San Francisco (UCSF) medical scientists have found. Younger patients, however, are likely to want to rapidly increase their medication dose, the researchers found, posing serious potential health consequences.

20 May 2005

Human cells can silence an essential part of HIV's genetic make-up

For the first time, scientists have shown that humans use an immune defense process common in plants and invertebrates to battle a virus.

19 May 2005

Birth weight and breastfeeding in infancy may affect premenopausal breast cancer risk

Premenopausal women who were heavier than average at birth or had not been breastfed as infants appear to be at increased risk for developing breast cancer, epidemiologists at the University at Buffalo's School of Public health and Health Professions have found.

19 May 2005

Britain's Royal Society contributes little to medical science

The Royal Society today has contributed little to medical science and should undergo an urgent review of its purpose and programmes, states an editorial in this week’s issue of The Lancet.

19 May 2005

Statement from The Lancet in response to Stephen Cox of The Royal Society

The statement from Stephen Cox published (May 19, 2005) is astonishing. He fails to address any of the arguments set out in The Lancet’s editorial of May 21, 2005. His deeply personal invective directed against me, in response to an editorial that avoided all direct personal criticism of individuals, does a disservice to his important role as Executive Secretary of the Royal Society. Here are the facts:

19 May 2005

Research News and Research

FDA recommends approval of the investigational anti-HIV drug tipranavir

Study holds implications for gene therapy and stem cell biology

Physiotherapy is effective in treating stress incontinence

Judges perceive child witnesses as being more honest than adults when testifying in court

Nurture as important as nature in developing ability for flexible self-control

Merck cervical cancer virus vaccine performs well

So you thought that smell was cheese!

Extolling the safety of childhood vaccinations may only serve to strengthen the positions of those philosophically opposed to them

Drug used to treat enlarged prostate may improve the accuracy of prostate biopsies

Cetuximab (Erbitux) can battle cancer and prolong life in many patients with advanced colorectal cancer

Cystatin-C, a new blood test for kidney function, is a better predictor of death and cardiovascular risk among the elderly

Studies on Hormone Replacement Therapy (HRT) for breast cancer patients can give false hopes

Sigmoidoscopy comes up short for women in detection of polyps in the colon

New kidney test better elder mortality predictor

Bacteria in plaque may increase risk for heart attacks

Narcotic medications can safely and effectively ease severe, chronic pain in older people

Human cells can silence an essential part of HIV's genetic make-up

Birth weight and breastfeeding in infancy may affect premenopausal breast cancer risk

Britain's Royal Society contributes little to medical science

Statement from The Lancet in response to Stephen Cox of The Royal Society

A new way of characterising biomolecules eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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