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Results of Creutzfeldt-Jakob disease research in people who received human growth hormone from cadavers

The largest study of its kind, designed to track the development of Creutzfeldt-Jakob disease in people who received human growth hormone from cadavers, has found that the vast majority of those who received the hormone did not contract the fatal condition. However, some recipients (26 out of approximately 7,700) did develop the disease.

7 Apr 2004

The Cambridge-MIT Institute has launched a project to tackle the bottlenecks that slow development of new drugs

The Next-Generation Drug Discovery Community will unite researchers at Cambridge University and MIT with partners from the information technology, pharmaceutical and biotechnology industries to find ways to speed up development of the next generation of drugs--particularly those that treat diseases with complex causes such as cancers, arthritis, multiple sclerosis and diabetes.

7 Apr 2004

Protein kinase complex influences the outer layer of skin to control the eventual shape of the full-grown skeleton and skull

Continuing studies about an important regulatory protein kinase complex called I-kappa-B kinase (or IKK) have now shown that a subunit of IKK – IKK alpha – influences the outer layer of skin in developing mice to control the eventual shape of the full-grown skeleton and skull.

7 Apr 2004

Genetic trick makes gene therapy vectors more versatile

A genetic trick used by viruses to replicate themselves has been adapted for laboratory use to build complex protein structures required by immune system cells, according to investigators at St. Jude Children’s Research Hospital.

7 Apr 2004

Molecular analyses of leukemia patients suggest strategies for better treatments

The cure rate for pediatric acute lymphoblastic leukemia (ALL) might continue to rise with improved use of conventional therapies. But even more effective and less toxic therapies based on genetic and pharmacogenetic studies might one day push the success rate close to 100 percent, according to an article published by investigators at St. Jude Children’s Research Hospital in the April 8 issue of the New England Journal of Medicine.

7 Apr 2004

Pharmacopeia announces that proposed spin-off of Pharmacopeia Drug Discovery, Inc. unit is expected to occur by the end of April 2004

Pharmacopeia, Inc. today announced that the proposed spin-off of its Pharmacopeia Drug Discovery, Inc. (PDD) unit is expected to occur by the end of April 2004. The Pharmacopeia Board of Directors intends to meet next week to consider final approval of the pro rata distribution to stockholders of 100% of the common stock of PDD.

7 Apr 2004

Research shows that intense high dose cholesterol lowering drugs result in a major reduction in deaths and severe heart attacks

If you want to increase your chances of living longer, taking cholesterol drugs is an easy way to do it. That's the message from a Harvard study of 4,162 people hospitalized in 350 places in eight countries. It is the first research to show that intense lowering of cholesterol results in a major reduction in deaths and severe heart attacks.

7 Apr 2004

A protein involved in the release of neurotransmitters in the brain is essential to learning and memory

A study published today in Neuron offers the first evidence that lack of this protein - known as RIM1 alpha - causes profound deficits in the learning process. The discovery is a major step in understanding the molecular events that underlie learning and memory - complex processes that can be impaired in human neuropsychiatric disorders such as Alzheimer's disease, mental retardation and schizophrenia.

7 Apr 2004

Time-reversal acoustics research promises medical breakthroughs

Scientists have not yet found a way to actually make time run backward, but in the cutting-edge world of recent acoustics research, they have shown a way to make sound waves run backward in a kind of ultra-focused reverse echo. By the technology known as time-reversal acoustics, sound waves - in exact reverse order from the original sound - echo directly and very precisely back to their source point.

7 Apr 2004

New research findings in study of Rett Syndrome

Rudolf Jaenisch of the Whitehead Institute of Biomedical Research in Cambridge, MA reports in the April 6, 2004 online issue of the Proceedings of the National Academy of Sciences that introduction of the MeCP2 protein into post-mitotic nerve cells of MeCP2 mutant mice rescues the symptoms of Rett Syndrome. This raises the possibility that neurons are functionally normal in a newborn child and that neural dysfunction manifests itself only later due to prolonged MeCP2 deficiency. If correct, therapeutic strategies aimed at preventing the onset of Rett symptoms could be initiated at birth.

7 Apr 2004

Boston University Professor Offers Tips for Healthy Gardening and Other Activities

Do you find yourself hesitating to perform favorite springtime activities because of the pain and discomfort associated with bending and kneeling? A Boston University (BU) occupational therapy professor has a solution to this problem, which affects thousands of people each year.

7 Apr 2004

Women with a history of pre-eclampsia are at increased risk of cancer

Women with a history of pre-eclampsia are at increased risk of cancer, particularly cancers of the stomach, breast, ovary, lung and larynx, according to a Columbia University study recently published by the British Medical Journal. Researchers studied 37,000 women in western Jerusalem, Israel, who delivered babies in three large hospitals between 1964 and 1976.

7 Apr 2004

International obesity experts form a team to review and evaluate obesity

In an effort to help medical professionals, policy-makers, researchers, the news media and the general public evaluate the quality and usefulness of obesity research, a group of international obesity experts has formed a team that will review and evaluate published research papers in the field of obesity.

7 Apr 2004

Effects of lead in petrol are well-known however a recent additive to petrol manganese may be just as toxic

The disastrous environmental and health effects of lead in petrol are well-known, and western countries have been phasing it out for many years now. However, a recent additive to petrol - manganese - may be just as toxic. A Macquarie University study aims to find out.

7 Apr 2004

Completion of the sequencing of human chromosome 19

The United States Department of Energy (DOE) Joint Genome Institute (JGI) and Stanford University report today the completion of the sequencing of human chromosome 19, the most gene-rich of all the human chromosomes. This achievement is described in the April 1, 2004 edition of the journal Nature.

7 Apr 2004

Patients with coronary artery blockages can be treated safely using drug coated stents

The researchers followed 155 consecutive patients treated with multiple sirolimus-eluting stents between April 2002 and March 2003. Each patient had at least two lesions blocking blood flow in different coronary arteries. Earlier studies have demonstrated that patients with a single, simple artery narrowing held open with a sirolimus-eluting stent are less likely to need retreatment than similar patients who received a bare metal stent. However, those studies excluded patients with complex or multiple artery lesions.

6 Apr 2004

FDA accepts REMICADE® (infliximab) for the treatment of early rheumatoid arthritis

Centocor, Inc., announced today that the U.S. Food and Drug Administration (FDA) has accepted its filing of a supplemental Biologics License Application (sBLA) for REMICADE® (infliximab) as first-line therapy, in combination with methotrexate, for the treatment of early rheumatoid arthritis (RA) patients with moderately-to-severely active disease. REMICADE®, in combination with methotrexate, is currently indicated in the U.S. for reducing signs and symptoms, inhibiting the progression of structural damage and improving physical function in patients with moderately-to-severely active RA who have had an inadequate response to methotrexate alone.

6 Apr 2004

New study could lead to new drugs to prevent premature birth

Dr Raheela Khan, of the University’s Academic Division of Obstetrics and Gynaecology based at the newly-opened University of Nottingham Medical School at Derby, is working with colleagues Dr Balwir Matharoo-Ball and Dr Dave Barratt in the University’s School of Pharmacy on the research looking at what makes some women go into labour before their baby is due.

6 Apr 2004

Trauma Highly Prevalent Among Delinquents

Almost every boy and girl currently detained in a juvenile facility in the United States has experienced at least one major trauma, and a large proportion of these children have post-traumatic stress disorder, according to a study in the April issue of Archives of General Psychiatry.

6 Apr 2004

A new technique for engineering protein crystals is helping scientists figure out the three-dimensional structures of some important biological molecules

A new technique for engineering protein crystals is helping scientists figure out the three-dimensional structures of some important biological molecules, including a key plague protein whose structure has eluded researchers until now. The technique, developed with support from the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH), promises to help pharmaceutical companies develop more effective drugs to treat various diseases by tailor-making molecules to "fit" a protein's shape.

6 Apr 2004

Research News and Research

Results of Creutzfeldt-Jakob disease research in people who received human growth hormone from cadavers

The Cambridge-MIT Institute has launched a project to tackle the bottlenecks that slow development of new drugs

Protein kinase complex influences the outer layer of skin to control the eventual shape of the full-grown skeleton and skull

Genetic trick makes gene therapy vectors more versatile

Molecular analyses of leukemia patients suggest strategies for better treatments

Pharmacopeia announces that proposed spin-off of Pharmacopeia Drug Discovery, Inc. unit is expected to occur by the end of April 2004

Research shows that intense high dose cholesterol lowering drugs result in a major reduction in deaths and severe heart attacks

A protein involved in the release of neurotransmitters in the brain is essential to learning and memory

Time-reversal acoustics research promises medical breakthroughs

New research findings in study of Rett Syndrome

Boston University Professor Offers Tips for Healthy Gardening and Other Activities

Women with a history of pre-eclampsia are at increased risk of cancer

International obesity experts form a team to review and evaluate obesity

Effects of lead in petrol are well-known however a recent additive to petrol manganese may be just as toxic

Completion of the sequencing of human chromosome 19

Patients with coronary artery blockages can be treated safely using drug coated stents

FDA accepts REMICADE® (infliximab) for the treatment of early rheumatoid arthritis

New study could lead to new drugs to prevent premature birth

Trauma Highly Prevalent Among Delinquents

A new technique for engineering protein crystals is helping scientists figure out the three-dimensional structures of some important biological molecules

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