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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Inhibiting inflammatory signaling pathway could reduce the chances of heart disease in cancer survivors

Researchers at Memorial Sloan Kettering Cancer Center (MSKCC) in New York have discovered that common cancer treatments, such as radiotherapy or anthracycline drugs, cause long-term damage to heart tissue by activating a key inflammatory signaling pathway.

19 Dec 2022

Modulation of insect immunity to control vector-borne diseases

Discussed the current research on the role of molecular mechanisms in mediating immune priming in insects and regulating vector-borne disease transmission.

19 Dec 2022

Decoding nucleic acid-based drugs and vaccines through SEC-SLS analysis

In this interview, Malvern Panalytical’s Product Technical Specialist, Stefan Cairns, discusses how SEC-SLS can be used to understand MRNA vector composition by referencing his latest publication.

From Malvern Panalytical 19 Dec 2022

Cryo-electron microscopy reveals atomic structure of Staphylococcus epidermidis bacteriophage

Cryo-electron microscopy by University of Alabama at Birmingham researchers has exposed the structure of a bacterial virus with unprecedented detail.

18 Dec 2022

Genome assembly tool could spur the development of new treatments for tuberculosis

Researchers have developed a novel genome assembly tool that could spur the development of new treatments for tuberculosis and other bacterial infections.

16 Dec 2022

ACMG's new guideline strongly recommends the use of noninvasive prenatal screening for fetal chromosome abnormalities

The American College of Medical Genetics and Genomics (ACMG) has released a new Evidence-Based Clinical Practice Guideline (EBG), "Noninvasive prenatal screening for fetal chromosome abnormalities in a general-risk population: An evidence-based clinical guideline of the American College of Medical Genetics and Genomics."

16 Dec 2022

Mucosal DNA vaccine provides protection against lethal SARS-CoV-2 in mice

Less known to the general public, mucosal vaccination via the mucus membranes could provide robust protection against SARS-CoV-2 infections.

16 Dec 2022

Study to determine if a DNA-based blood test can help detect cancer predisposition in NF1 patients

The Children’s Tumor Foundation (CTF) has announced a groundbreaking 3-year study, which it will fund for nearly $2 million, to determine if a DNA-based blood test can offer better understanding and ultimately earlier diagnosis of cancer predisposition in neurofibromatosis type 1 (NF1) patients.

16 Dec 2022

NEJM study shows hidden genetic anomaly behind common late-onset cerebellar ataxia

Researchers at the University of Miami Miller School of Medicine, McGill University and other institutions have found that a well-concealed genetic variation in the gene FGF14, called a DNA tandem repeat expansion, causes a common form of late-onset cerebellar ataxia, a brain disorder that interferes with coordinated movement.

16 Dec 2022

Study provides new insights into the pathology of LATE

Limbic predominate age-related TDP-43 encephalopathy or LATE is a recently recognized form of dementia that affects memory, thinking and social skills. It mimics Alzheimer's disease or AD (and sometimes co-exists with it), but LATE is a different condition, with its own risks and causes.

16 Dec 2022

Cryo-microscopy reveals high-resolution structure of monkeypox virus DNA polymerase holoenzyme

Using cryo-microscopy, researchers present a high-resolution structure of monkeypox virus DNA polymerase holoenzyme, a complex that plays a key role in the genome replication process of the virus.

16 Dec 2022

New mutations near known genes could contribute to the increase in cleft lip and palate risk

Cleft lip and palate are among the most common congenital malformations, which are mainly due to genetic causes.

16 Dec 2022

Study reveals subtypes and EBV-associated regulatory epigenome reprogramming in nasopharyngeal carcinoma

Researchers from the Department of Clinical Oncology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) discovered a novel subtype of Epstein-Barr Virus (EBV)-positive nasopharyngeal carcinoma (NPC) and EBV-associated immunosuppression in the tumor microenvironment (TME).

16 Dec 2022

Next-generation sequencing could change research on sexual assault cases

In this interview, Alexis Garloff talks to NewsMedical about her next-generation sequencing research and the possible applications in forensics, particularly in sexual assault cases.

From Verogen, Inc. 16 Dec 2022

The mpox viral load kinetics over time in various parts of the body

Researchers characterized the time to mpox virus clearance of immunocompetent individuals with mild MPX in a real-world community-based setting utilizing longitudinal information.

16 Dec 2022

Sphere Fluidics appoints Richard Hammond as Chief Technical Officer

Sphere Fluidics, a company developing single cell analysis systems underpinned by its patented picodroplet technology, announced today that it has appointed Richard Hammond as Chief Technical Officer.

From Sphere Fluidics 16 Dec 2022

mRNA vaccine methodologies: Production, value and spectrometer use

To be decided by the editor

From Thermo Fisher Scientific – Materials & Structural Analysis 16 Dec 2022

How do predicted ecological niches of the mpox virus compare with that of 99 mammal species?

Researchers compared ecological niches to identify probable mpox virus reservoir hosts.

15 Dec 2022

Sheep milk could be an inexpensive source of therapeutic polyclonal SARS-CoV-2 neutralizing antibodies

Researchers used sheep, a ruminant mammal, to obtain polyclonal immunoglobulins (IgGs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

15 Dec 2022

Study uncovers previously unknown genetic cause of late-onset cerebellar ataxia

A new study published on Dec. 14, 2022 in the New England Journal of Medicine reports the identification of a previously unknown genetic cause of a late-onset cerebellar ataxia, a discovery that will improve diagnosis and open new treatment avenues for this progressive condition.

15 Dec 2022

DNA News and Research

Further Reading

Inhibiting inflammatory signaling pathway could reduce the chances of heart disease in cancer survivors

Modulation of insect immunity to control vector-borne diseases

Decoding nucleic acid-based drugs and vaccines through SEC-SLS analysis

Cryo-electron microscopy reveals atomic structure of Staphylococcus epidermidis bacteriophage

Genome assembly tool could spur the development of new treatments for tuberculosis

ACMG's new guideline strongly recommends the use of noninvasive prenatal screening for fetal chromosome abnormalities

Mucosal DNA vaccine provides protection against lethal SARS-CoV-2 in mice

Study to determine if a DNA-based blood test can help detect cancer predisposition in NF1 patients

NEJM study shows hidden genetic anomaly behind common late-onset cerebellar ataxia

Study provides new insights into the pathology of LATE

Cryo-microscopy reveals high-resolution structure of monkeypox virus DNA polymerase holoenzyme

New mutations near known genes could contribute to the increase in cleft lip and palate risk

Study reveals subtypes and EBV-associated regulatory epigenome reprogramming in nasopharyngeal carcinoma

Next-generation sequencing could change research on sexual assault cases

The mpox viral load kinetics over time in various parts of the body

Sphere Fluidics appoints Richard Hammond as Chief Technical Officer

mRNA vaccine methodologies: Production, value and spectrometer use

How do predicted ecological niches of the mpox virus compare with that of 99 mammal species?

Sheep milk could be an inexpensive source of therapeutic polyclonal SARS-CoV-2 neutralizing antibodies

Study uncovers previously unknown genetic cause of late-onset cerebellar ataxia

eBook: A guide to RNA sequencing eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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