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Scientists explore popular pre-heart transplant therapy’s impact on kidney function

Scientists, nephrologists and cardiac surgeons from The Feinstein Institute for Medical Research and Northwell Health's Department of Internal Medicine, Cardiology and Cardio-Thoracic Surgery examined the impact of a popular pre-heart transplant therapy on the kidney in a study published today by The Clinical Journal of the American Society of Nephrology.

26 Oct 2017

VICC selected to administer FDA-approved CAR T therapy for treatment of lymphoma patients

Vanderbilt-Ingram Cancer Center has been selected as one of the few authorized treatment centers in the United States approved to administer the first FDA- approved chimeric antigen receptor T cell (CAR T) therapy for treatment of adult patients with a specific type of lymphoma.

25 Oct 2017

Researchers find rare genetic variants that may help explain longevity in some CF patients

Cystic fibrosis is an inherited disorder caused by genetic mutations that disrupt the normal movement of chloride in and out of cells. Among other health problems, cystic fibrosis compromises the lungs' ability to fight infection and breathe efficiently, making it the most lethal genetic disease in the Caucasian population. Patients have an average lifespan of just 30 to 40 years.

25 Oct 2017

Researchers develop new way to genetically engineer T cells for treating leukemia relapse

Researchers at Fred Hutchinson Cancer Research Center and the University of Washington have developed a novel way to genetically engineer T cells that may be effective for treating and preventing leukemia relapse.

25 Oct 2017

VUMC reaches new milestone after performing 2,000th liver transplant

This month, Vanderbilt University Medical Center performed its 2,000th liver transplant, another milestone for one of the largest liver transplant programs in the Southeast.

20 Oct 2017

Study examines risk of using liver organs from hepatitis C positive donors

Use of liver organs from selected hepatitis C positive donors should be considered due to modest risk of hepatitis C transmission and the availability of safe and effective direct‐acting antiviral therapies, according to research presented this week at The Liver Meeting -; held by the American Association for the Study of Liver Diseases.

20 Oct 2017

Increased use of split liver transplantation could decrease pediatric waitlist deaths

A new study presented this week at The Liver Meeting - held by the American Association for the Study of Liver Diseases - found that increased utilization of split liver transplantation (sharing a donor liver between one pediatric and one adult patient) could decrease the number of children who die awaiting liver transplantation without decreasing liver transplantation access for adult patients.

20 Oct 2017

Study finds rise in pregnancy rates among women with chronic liver disease

A new study presented this week at The Liver Meeting – held by the American Association for the Study of Liver Diseases – found that the overall number of pregnancies in women with chronic liver disease or following liver transplantation has risen over the past 30 years.

20 Oct 2017

Kidney failure linked to lower quality of life, psychosocial challenges in young adults

Kidney failure is associated with lower quality of life in young people and limited employment, independence, and relationships compared with healthy peers, according to an analysis appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology

20 Oct 2017

Families stop donation of organs from deceased relatives who are registered donors

Hundreds of families across England block the donation of organs from deceased relatives, despite the deceased having chosen to sign the Organ Donation Register.

19 Oct 2017

Cascade of costs could push new gene therapy above $1 million per patient

Outrage over the high cost of cancer care has focused on skyrocketing drug prices, including the $475,000 price tag for the country's first gene therapy, Novartis' Kymriah, a leukemia treatment approved in August.

17 Oct 2017

Surgeries performed later in the day linked to increased risk of complications

A new study published in Neurosurgery finds that patients who undergo a neurosurgical procedure with surgical start times between 9 pm and 7 am are at an increased risk of developing complications compared to patients with a surgical start time earlier in the day.

13 Oct 2017

New study uncovers 13 previously-unknown genetic risk variants for restless legs syndrome

A new study into the genetics underlying restless legs syndrome has identified 13 previously-unknown genetic risk variants, while helping inform potential new treatment options for the condition.

13 Oct 2017

Calcium controls use of glucose by T cells to multiply and battle against infection, study finds

A calcium signal controls whether immune cells can use the nutrients needed to fuel their multiplication into a cellular army designed to fight invading viruses.

11 Oct 2017

Limiting damage after donation could reduce discard rate of organs, study shows

A new study indicates that many donated organs that are discarded might be suitable for transplantation if certain steps are taken to limit damage following donation. The findings appear in an upcoming issue of the Journal of the American Society of Nephrology.

9 Oct 2017

Study uncovers differences in bacterial composition of healthy vs. cancerous breast tissue

In a newly published study, Cleveland Clinic researchers have uncovered differences in the bacterial composition of breast tissue of healthy women vs. women with breast cancer.

6 Oct 2017

Study to determine lowest dose of chemotherapy needed for babies with SCID

Michael Pulsipher, MD, of the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles, along with co-principal investigator, Sung-Yun Pai, MD, of Boston Children's Hospital, has been awarded nearly $9 million from the National Institute of Allergy and Infectious Diseases of the NIH to study a new treatment approach for babies born with severe combined immunodeficiency (SCID) which prevents the immune system from functioning normally.

6 Oct 2017

Donor organs labeled as increased risk less likely to be used by transplant patients

Increasingly, transplant surgeons must initiate a tough conversation: explaining to patients what it means to accept an organ from a person who died from a drug overdose.

5 Oct 2017

Moms of children with rare genetic illness push for wider newborn screening

Kerri De Nies received the news this spring from her son's pediatrician: Her chubby-cheeked toddler had a rare brain disorder.

5 Oct 2017

Gene therapy effectively stabilizes progression of cerebral adrenoleukodystrophy, trial reveals

In a recent clinical trial, a gene therapy to treat cerebral adrenoleukodystrophy (CALD) -- a neurodegenerative disease that typically claims young boys' lives within 10 years of diagnosis -- effectively stabilized the disease's progression in 88 percent of patients, researchers from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Massachusetts General Hospital report today.

4 Oct 2017

Transplant News and Research

Scientists explore popular pre-heart transplant therapy’s impact on kidney function

VICC selected to administer FDA-approved CAR T therapy for treatment of lymphoma patients

Researchers find rare genetic variants that may help explain longevity in some CF patients

Researchers develop new way to genetically engineer T cells for treating leukemia relapse

VUMC reaches new milestone after performing 2,000th liver transplant

Study examines risk of using liver organs from hepatitis C positive donors

Increased use of split liver transplantation could decrease pediatric waitlist deaths

Study finds rise in pregnancy rates among women with chronic liver disease

Kidney failure linked to lower quality of life, psychosocial challenges in young adults

Families stop donation of organs from deceased relatives who are registered donors

Cascade of costs could push new gene therapy above $1 million per patient

Surgeries performed later in the day linked to increased risk of complications

New study uncovers 13 previously-unknown genetic risk variants for restless legs syndrome

Calcium controls use of glucose by T cells to multiply and battle against infection, study finds

Limiting damage after donation could reduce discard rate of organs, study shows

Study uncovers differences in bacterial composition of healthy vs. cancerous breast tissue

Study to determine lowest dose of chemotherapy needed for babies with SCID

Donor organs labeled as increased risk less likely to be used by transplant patients

Moms of children with rare genetic illness push for wider newborn screening

Gene therapy effectively stabilizes progression of cerebral adrenoleukodystrophy, trial reveals

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