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Blood cancer treatment linked to distinct increase in molecular age of immune cells

Certain cancer treatments are known to take a toll on patients, causing side effects like fatigue, nausea and hair loss. Now, scientists are investigating whether some treatments can cause another long-term side effect: premature aging of important disease-fighting cells.

1 Sep 2016

Scientists generate functional tissue-engineered liver from adult stem and progenitor cells

A research team led by investigators at The Saban Research Institute of Children's Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells.

31 Aug 2016

Transplantation of placenta-derived MSCs can prevent diabetes-related CLI in rats

In an effort to determine if stem cell therapy can prevent or improve a condition called "diabetic foot" caused by poor blood flow in patients with diabetes, a team of researchers in China has found that transplanting human placenta-derived mesenchymal stem cells (MSCs) into rats modeled with diabetes can affect blood vessel growth, potentially improving blood flow and preventing critical limb ischemia (CLI), a condition that results in diabetic foot and frequently leads to amputation.

30 Aug 2016

Study suggests autologous EPC transfusion may prevent miscarriage in high-risk pregnancies

In a study focusing on the role of self-donated (autologous) bone marrow-derived endothelial progenitor cells (EPCs) in placental vascular development, researchers in Japan have discovered that when transplanted into pregnant mice, EPCs can contribute to better blood vessel growth that helps in forming "normalized" placental vascularization, leading, in turn, to reduced recurrent miscarriages by providing a healthier fetal environment during gestation.

30 Aug 2016

Researchers find better way to purify liver cells made from induced pluripotent stem cells

A research team including developmental biologist Stephen A. Duncan, D. Phil., SmartState Chair of Regenerative Medicine at the Medical University of South Carolina, has found a better way to purify liver cells made from induced pluripotent stem cells (iPSCs).

30 Aug 2016

Scripps collaborates with MD Anderson for clinically integrated cancer care program

Scripps Health and The University of Texas MD Anderson Cancer Center have reached a partnership agreement to create Scripps MD Anderson Cancer Center, a comprehensive and clinically integrated cancer care program in San Diego that will provide adult cancer patients greater access to the most advanced oncology care available throughout Southern California.

29 Aug 2016

Outpatient CLABSIs costly for pediatric stem cell transplant and oncology patient population

Pediatric stem cell transplant and cancer patients often are discharged from the hospital with an external central venous line for medications that parents or other caregivers must clean and flush daily to avoid potentially life-threatening infections.

29 Aug 2016

Novel drug-dispensing contact lens effective in providing better pressure reduction in glaucoma model

A contact lens designed to deliver medication gradually to the eye could improve outcomes for patients with conditions requiring treatment with eye drops, which are often imprecise and difficult to self-administer.

29 Aug 2016

MRI-guided focused ultrasound treatment improves quality of life in patients with essential tremor

Treatment with MRI-guided focused ultrasound significantly improves tremors and quality of life in patients with essential tremor (ET), the most common movement disorder, according to a study published in the August 25 issue of the New England Journal of Medicine.

27 Aug 2016

Researchers find new way for early prediction of leukemic relapse

Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA-based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.

26 Aug 2016

Breakthrough in cancer cell screening advances personalised treatment of childhood leukaemia

Researchers at Newcastle University have been able to accurately predict how children whose cancer returns after treatment for leukaemia are likely to respond to further treatment.

26 Aug 2016

Researchers discover novel pathway for immune recovery following bone-marrow transplantation

New research has shown how a cell surface molecule, Lymphotoxin β receptor, controls entry of T-cells into the thymus; and as such presents an opportunity to understanding why cancer patients who undergo bone-marrow transplant are slow to recover their immune system.

25 Aug 2016

New noninvasive treatment option improves quality of life in patients with essential tremor

25 Aug 2016

Research findings could lead to new ways of preventing or treating organ transplant rejection

An international team led by researchers from the University of Pittsburgh School of Medicine found that targeting certain donor cells lowered the risk of organ rejection in mice that underwent kidney and heart transplants.

24 Aug 2016

Assigning barcode to stem cells makes it possible to monitor large blood cell populations

By assigning a barcode to stem cells, researchers at Lund University in Sweden have made it possible to monitor large blood cell populations as well as individual blood cells, and study the changes over time.

24 Aug 2016

Transient dose of rapamycin in middle age can increase life expectancy, improve measures of healthy aging

Geroscience researchers studying the biology of aging briefly treated middle-aged mice with the drug rapamycin to gauge the long-term effects of short-term therapy on health and longevity.

24 Aug 2016

Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Dyskeratosis congenita, or DC, is a rare, inherited disease for which there are limited treatment options and no cure.

18 Aug 2016

Complex instructions, caregiver empathy may play key role in raising post-transplant anxiety

Some anxiety is perfectly normal for kidney transplant patients, but new research suggests that medical staff can help patients feel more at ease when they leave the hospital and that could decrease the chances they'll be readmitted.

18 Aug 2016

Stem cells derived from bone marrow provide better quality of life to transplant patients

A large, nationwide study published in the journal JAMA Oncology found that people who received transplants of cells collected from a donor's bone marrow the original source for blood stem cell transplants, developed decades ago had better self-reported psychological well-being, experienced fewer symptoms of a common post-transplant side effect called graft-vs.-host disease and were more likely to be back at work five years after transplantation than those whose transplanted cells were taken from the donor's bloodstream.

17 Aug 2016

German scientists develop new approach to prevent GvHD after bone marrow transplants

Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft-versus-host disease (GvHD) after therapeutic bone marrow transplants.

16 Aug 2016

Transplant News and Research

Blood cancer treatment linked to distinct increase in molecular age of immune cells

Scientists generate functional tissue-engineered liver from adult stem and progenitor cells

Transplantation of placenta-derived MSCs can prevent diabetes-related CLI in rats

Study suggests autologous EPC transfusion may prevent miscarriage in high-risk pregnancies

Researchers find better way to purify liver cells made from induced pluripotent stem cells

Scripps collaborates with MD Anderson for clinically integrated cancer care program

Outpatient CLABSIs costly for pediatric stem cell transplant and oncology patient population

Novel drug-dispensing contact lens effective in providing better pressure reduction in glaucoma model

MRI-guided focused ultrasound treatment improves quality of life in patients with essential tremor

Researchers find new way for early prediction of leukemic relapse

Breakthrough in cancer cell screening advances personalised treatment of childhood leukaemia

Researchers discover novel pathway for immune recovery following bone-marrow transplantation

New noninvasive treatment option improves quality of life in patients with essential tremor

Research findings could lead to new ways of preventing or treating organ transplant rejection

Assigning barcode to stem cells makes it possible to monitor large blood cell populations

Transient dose of rapamycin in middle age can increase life expectancy, improve measures of healthy aging

Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Complex instructions, caregiver empathy may play key role in raising post-transplant anxiety

Stem cells derived from bone marrow provide better quality of life to transplant patients

German scientists develop new approach to prevent GvHD after bone marrow transplants

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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