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FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

iCell Gene Therapeutics today (Aug. 11) announced that the Food and Drug Administration has granted Orphan Drug Designation for its chimeric antigen receptor engineered T-cells directed against the target protein CD4 (CD4CAR) for the treatment of peripheral T-cell lymphoma (PTCL).

12 Aug 2016

Scientists find new functions of ANG protein that plays key role in regulation of blood cell formation

Tufts Medical Center and Tufts University scientists have found exciting, new functions of the protein angiogenin that play a significant role in the regulation of blood cell formation, important in bone marrow transplantation and recovery from radiation-induced bone marrow failure.

11 Aug 2016

Antioxidant compound could be effective to combat immune rejection after islet transplantation

A team of researchers has found that doses of bilirubin help provide suppression of the immune response following islet transplantation in mouse models.

11 Aug 2016

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Johns Hopkins researchers say they have identified a new disease gene that, when mutated, appears to increase the risk in a small number of people of developing emphysema and a lung-scarring condition known as pulmonary fibrosis.

10 Aug 2016

Scientists improve potential weapon to fight against autoimmune disorders

With a trick of engineering, scientists at the Gladstone Institutes improved a potential weapon against inflammation and autoimmune disorders. Their work could one day benefit patients who suffer from inflammatory bowel disease or organ transplant rejection.

9 Aug 2016

Study shows universal health insurance may mitigate surgical disparities for African Americans

A new study from Brigham and Women's Hospital utilized claims data from more than 630,000 patients living in the state of California and found no significant differences in post-operative complications or mortality between African American patients and White patients who were treated in a universally insured military health system.

9 Aug 2016

DASH-style diet could help lower risk of developing chronic kidney disease

People who ate a diet high in nuts and legumes, low-fat dairy, whole grains, fruits, and vegetables and low in red and processed meat, sugar-sweetened beverages and sodium were at a significantly lower risk of developing chronic kidney disease over the course of more than two decades, new Johns Hopkins Bloomberg School of Public Health research suggests.

9 Aug 2016

African-American men treated with ADT for prostate cancer suffer from high mortality rates

In a retrospective study analyzing patients' medical records, researchers at Brigham and Women's Hospital found that patients' race significantly affected their longevity by increasing the likelihood of death after receiving androgen deprivation therapy (ADT).

5 Aug 2016

New lung scanning platform holds potential to improve treatment for people with lung disease

New lung scanning technology developed at Monash University has the potential to transform treatment for millions of people with lung disease in Australia and around the world.

5 Aug 2016

Heart-resident macrophages promote neutrophil recruitment after ischemic injury

Tissue injury, such as occurs in response to a lack of oxygen, promotes an influx of immune cells to the site of damage.

5 Aug 2016

Stranger’s organ donation instigates six-way kidney swap

A stranger began a chain of events that eventually saved the lives of six people in desperate need of new kidneys. Her organ donation triggered a six-way kidney swap at Houston Methodist Hospital in July, the second largest of its kind performed at one institution in Texas.

2 Aug 2016

Cell-free DNA test could help identify liver transplant patients with acute rejection

Today, researchers presented findings at the 68th AACC Annual Scientific Meeting that DNA found circulating in the bloodstream—known as cell-free DNA—can be used to identify liver transplant patients with acute rejection with greater accuracy than conventional liver function tests.

1 Aug 2016

Smoking reduces lifespans and overall chances of kidney transplantation in dialysis patients

Dialysis patients who smoke are much less likely to receive a life-saving kidney transplant and much more likely to die sooner according to researchers from the Health Research Institute (HRI) at the University of Limerick and UL’s Graduate Entry Medical School.

29 Jul 2016

Novel conjugate therapy shows promise in destroying ALL cells with few side effects

Researchers at UC Davis and Ionis Pharmaceuticals have developed a hybrid treatment that harnesses a monoclonal antibody to deliver antisense DNA to acute lymphoblastic leukemia (ALL) cells and that may lead to less toxic treatments for the disease.

29 Jul 2016

Study explores ethnic differences in physical activity among kidney transplant patients

People's ethnicity impacts their physical activity following a kidney transplant, according to research carried out by the University of Leicester.

28 Jul 2016

Valley fever diagnosis often overlooked by primary care physicians

For patients with pneumonia or ongoing influenza-like symptoms who live in or have visited the west or southwest United States, especially Arizona and central California, infectious diseases experts recommend physicians suspect valley fever, an often-overlooked fungal infection.

28 Jul 2016

Researchers find promising new therapy for both pediatric and adult cancers

A study conducted at Nationwide Children's Hospital has found that a new chemotherapy is effective against both pediatric and adult cancers, and that it allows other chemotherapies to more readily reach their targets.

28 Jul 2016

Umbilical CBT more effective than MUD bone marrow transplants for leukemia patients

A University of Colorado Cancer Center study compared outcomes of leukemia patients receiving bone marrow transplants from 2009-2014, finding that three years post transplant, the incidence of severe chronic graft-versus-host disease was 44 percent in patients who had received transplants from matched, unrelated donors (MUD) and 8 percent in patients who had received umbilical cord blood transplants (CBT).

27 Jul 2016

Researchers test new approach to treat metabolic diseases without organ transplant

With a shortage of donor organs, Mayo Clinic is exploring therapeutic strategies for patients with debilitating liver diseases. Researchers are testing a new approach to correct metabolic disorders without a whole organ transplant. Their findings appear in Science Translational Medicine.

27 Jul 2016

Groundbreaking research opens door for prevention of cardiac fibrosis

Groundbreaking research from the University of Alberta and McGill University has opened the door towards the future prevention of cardiac fibrosis—a condition leading to heart failure for which there is currently no treatment.

27 Jul 2016

Transplant News and Research

FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

Scientists find new functions of ANG protein that plays key role in regulation of blood cell formation

Antioxidant compound could be effective to combat immune rejection after islet transplantation

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Scientists improve potential weapon to fight against autoimmune disorders

Study shows universal health insurance may mitigate surgical disparities for African Americans

DASH-style diet could help lower risk of developing chronic kidney disease

African-American men treated with ADT for prostate cancer suffer from high mortality rates

New lung scanning platform holds potential to improve treatment for people with lung disease

Heart-resident macrophages promote neutrophil recruitment after ischemic injury

Stranger’s organ donation instigates six-way kidney swap

Cell-free DNA test could help identify liver transplant patients with acute rejection

Smoking reduces lifespans and overall chances of kidney transplantation in dialysis patients

Novel conjugate therapy shows promise in destroying ALL cells with few side effects

Study explores ethnic differences in physical activity among kidney transplant patients

Valley fever diagnosis often overlooked by primary care physicians

Researchers find promising new therapy for both pediatric and adult cancers

Umbilical CBT more effective than MUD bone marrow transplants for leukemia patients

Researchers test new approach to treat metabolic diseases without organ transplant

Groundbreaking research opens door for prevention of cardiac fibrosis

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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