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Researchers find new innate immunity pathway that protects mammals from viral oncogenesis

Building upon earlier research, investigators at UT Southwestern Medical Center and their collaborators have identified a new innate immunity pathway that protects mammals from viral oncogenesis, the process by which viruses cause normal cells to become cancerous.

14 Mar 2016

Study shows gut microbes alter platelet function, heightens risk of heart attack and stroke

In a combination of both clinical studies of over 4,000 patients and animal model studies, Cleveland Clinic researchers have demonstrated -- for the first time -- that gut microbes alter platelet function and risk of blood clot-related illnesses like heart attack and stroke.

11 Mar 2016

PKM2 enzyme plays major role in early steps of wound healing

An enzyme involved in glucose metabolism in cells plays a major role in the early steps of wound healing, a finding that could lead to new therapeutic approaches for wound care, according to researchers at Georgia State University.

11 Mar 2016

Transplantation of periorbital tissues may be feasible alternative to protect vision in facial transplant patients

Transplantation of the periorbital tissues--the area surrounding the eyes--is a "technically feasible" alternative to protect a functioning eye in some patients being considered for facial transplant, according to a study in Plastic and Reconstructive Surgery--Global Open, the official open-access medical journal of the American Society of Plastic Surgeons.

11 Mar 2016

New procedure allows kidney transplants from incompatible donors

Researchers have found a way to stop patients rejecting kidneys that have come from incompatible donors, potentially slashing the waiting time for thousands of people in desperate need of the procedure.

10 Mar 2016

EAF celebrates first anniversary of Brussels Declaration on ADPKD, urges MEPs to unite for better patient care

On World Kidney Day, leading experts from the European ADPKD Forum today issue a collaborative letter to over 350 European decision makers (European Parliament, European Commission, Council representatives) celebrating the year one progress of the Brussels Declaration on ADPKD, while calling for urgent backing from policy makers to reduce the widespread inequalities and variations in care that remain.

10 Mar 2016

Pioneering progress on ADPKD: an interview with Tess Harris

ADPKD is a chronic, progressive and inherited kidney disease characterized by fluid-filled cysts that develop in the kidneys and other organs. It is the most common inherited kidney disease, and affects millions worldwide.

10 Mar 2016

Hematopoietic reprogramming can lead to differentiated blood products for cell-replacement therapy

Building upon previous work, researchers at the Icahn School of Medicine at Mount Sinai identified cells in the embryos of mice that are precursors to blood stem cells or hematopoietic stem/progenitor cells.

9 Mar 2016

Intervention program reduces caregiver distress during hospitalization of pediatric stem cell transplant patients

Research from an investigator at Rutgers Cancer Institute of New Jersey and colleagues from other facilities across the country, shows a social-cognitive intervention designed for parents of children undergoing a stem cell transplant had beneficial effects in reducing caregiver distress during the hospitalization period as compared with current best-practice psychosocial care.

9 Mar 2016

Modified protein appears to reverse liver fibrosis, cirrhosis in rats

A protein modified to increase the amount of time it circulates in the bloodstream appears to reverse liver fibrosis and cirrhosis in rats, according to results of a study led by Johns Hopkins researchers.

3 Mar 2016

Freestanding organ recovery facility for brain-dead donors increases organ transplant

Transplant surgeons report that obtaining organs from deceased organ donors costs much less and leads to a higher number of transplantable organs recovered when brain-dead donors are moved from the hospital to an independent, freestanding facility dedicated to organ recovery. Their study is published online as an "article in press" on the Journal of the American College of Surgeons website in advance of print publication later this year.

2 Mar 2016

First US uterus transplant is successful

The first US uterus transplant was performed this week by a team of surgeons at Cleveland Clinic, Cleveland, Ohio.

26 Feb 2016

SOM0226 (tolcapone) drug could significantly improve pharmacological treatment of ATTR

Researchers at the Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona (IBB-UAB), in collaboration with the biopharmaceutical company SOM Biotech, located in the Barcelona Science Park (PCB), have published, in Nature Communications, the results of a drug repositioning study in which they describe a powerful drug, SOM0226 (tolcapone) that could significantly improve the pharmacological treatment of familial transthyretin amyloidosis (ATTR).

24 Feb 2016

UMMC surgeons develop a program to direct critically ill patients to appropriate treatment location

A team of surgeons at the University of Maryland Medical Center has developed a program that utilizes its Shock Trauma Center (STC) model to direct critically ill non-trauma patients to the appropriate treatment location and get them into an operating room and hospital intensive care unit (ICU) bed as quickly as possible.

24 Feb 2016

Novel unit can significantly speed access to specialized care for critically ill patients

A novel unit to care for critically ill patients significantly speeds access to specialized care, according to a new study by physician scientists at the University of Maryland School of Medicine and the University of Maryland Medical Center.

24 Feb 2016

New clinical manual addresses controversial topic of organ donation after euthanasia

A new practical manual addresses the controversial topic of organ donation after euthanasia, providing guidance to clinicians whose patients have requested euthanasia and the desire to offer their organs to others in need.

24 Feb 2016

Beiging of white fat could be harnessed to combat diabetes

Researchers are getting closer to learning how to turn white fat cells into brown fat cells, in a process called "beiging," to bring down blood sugar levels and fight diabetes. The team, led by Joseph Baur, PhD, an assistant professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania published their findings this month in the journal Diabetes.

18 Feb 2016

Allo-HSCT Non-Relapse Related Mortality Reduction Revealed

A reduction in the risks of infection- and organ failure-related death has driven an improvement in non-relapse mortality among recipients of allogeneic haematopoietic stem cell transplantation, Japanese research suggests.

17 Feb 2016

NUS-led study reveals key player contributing to maintenance of hematopoietic stem cells

A study led by scientists from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has uncovered a key player contributing to the maintenance of hematopoietic stem cells (HSCs), blood cell precursors which have the ability to become any type of blood cell in the body.

17 Feb 2016

Study reveals another clue to workings of trachoma

Another clue to the workings of trachoma - the world's leading infectious cause of blindness - has been revealed in a new study published in BMC Infectious Diseases. Researchers identified markers of genetic regulation present in the early stages of infection that could predispose children to developing the condition in its long-term, severe form.

17 Feb 2016

Transplant News and Research

Researchers find new innate immunity pathway that protects mammals from viral oncogenesis

Study shows gut microbes alter platelet function, heightens risk of heart attack and stroke

PKM2 enzyme plays major role in early steps of wound healing

Transplantation of periorbital tissues may be feasible alternative to protect vision in facial transplant patients

New procedure allows kidney transplants from incompatible donors

EAF celebrates first anniversary of Brussels Declaration on ADPKD, urges MEPs to unite for better patient care

Pioneering progress on ADPKD: an interview with Tess Harris

Hematopoietic reprogramming can lead to differentiated blood products for cell-replacement therapy

Intervention program reduces caregiver distress during hospitalization of pediatric stem cell transplant patients

Modified protein appears to reverse liver fibrosis, cirrhosis in rats

Freestanding organ recovery facility for brain-dead donors increases organ transplant

First US uterus transplant is successful

SOM0226 (tolcapone) drug could significantly improve pharmacological treatment of ATTR

UMMC surgeons develop a program to direct critically ill patients to appropriate treatment location

Novel unit can significantly speed access to specialized care for critically ill patients

New clinical manual addresses controversial topic of organ donation after euthanasia

Beiging of white fat could be harnessed to combat diabetes

Allo-HSCT Non-Relapse Related Mortality Reduction Revealed

NUS-led study reveals key player contributing to maintenance of hematopoietic stem cells

Study reveals another clue to workings of trachoma

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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