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Gene-rich human Chromosome 19 sequence completed

The United States Department of Energy (DOE) Joint Genome Institute (JGI) and Stanford University report today the completion of the sequencing of human chromosome 19, the most gene-rich of all the human chromosomes.

31 Mar 2004

Research team has found a new way to streamline gene isolation to determine their functions

A single strand of plant or animal DNA may contain tens of thousands of genes, each programmed to produce a specific protein essential for the growth or survival of the organism. The challenge for geneticists is to isolate individual genes and determine their function -- a painstaking process often requiring years of laboratory trial and error.

31 Mar 2004

GenVec malaria vaccine initiative and the U.S. Naval Medical Research Center has announced partnership for malaria vaccine

GenVec, Inc., PATH's Malaria Vaccine Initiative (MVI), and the U.S. Naval Medical Research Center (NMRC) today announced a dynamic partnership to assess whether five malaria antigens, or proteins, can generate strong immune responses alone or in combination. This partnership will advance and expand the ongoing malaria vaccine development program between GenVec and NMRC. Malaria is one of the world's three leading infectious disease killers.

31 Mar 2004

Faster new cloning technique - transcript-based cloning

A single strand of plant or animal DNA may contain tens of thousands of genes, each programmed to produce a specific protein essential for the growth or survival of the organism. The challenge for geneticists is to isolate individual genes and determine their function – a painstaking process often requiring years of laboratory trial and error.

30 Mar 2004

Scientists find parallels between human speech and bird song which gives clues to human speech disorders.

The research by a team led by Stephanie White, UCLA assistant professor of physiological science, supports the theory that two genes shared by humans and songbirds, FoxP1 and FoxP2, may play a critical role in human speech, and speech disorders. The study is published March 31 in the Journal of Neuroscience.

30 Mar 2004

Zebrafish show effects of ionizing and UV radiation differ during embryo development

Adam Dicker, M.D., Ph.D., associate professor of radiation oncology at Jefferson Medical College of Thomas Jefferson University and Jefferson’s Kimmel Cancer Center in Philadelphia, Mary Frances McAleer, M.D., Ph.D., a resident in the Department of Radiation Oncology at Jefferson Medical College and their co-workers compared the effects on zebrafish embryos of two types of radiation – ionizing radiation, which is the kind given to patients for cancer treatment, and ultraviolet (UV) radiation, which comes naturally from the sun.

30 Mar 2004

Discovery of novel gene profile that may identify colon stem cells

Researchers at Jefferson Medical College have uncovered a novel pattern of gene expression in the stem cell-rich bottom of tiny “crypts” in the tissue lining the colon. By identifying these patterns, the scientists hope to be able to identify mechanisms through which stem cells contribute to the development of colon cancer.

30 Mar 2004

Extraction of RNA from Archived Formalin-Fixed, Paraffin-Embedded Tissue

For the first time, Fox Chase Cancer Center researchers have demonstrated the ability to extract RNA from formalin-fixed, paraffin-embedded tissue samples archived for up to five years. What's more, the technology used retrieves high-quality samples, allowing researchers to identify cancer-related genetic changes. Accepted as a "late-breaking" abstract, the research was presented today at the 95th Annual Meeting of the American Association for Cancer Research by Renata Coudry, M.D., a research pathologist at Fox Chase Cancer Center.

30 Mar 2004

Researchers find new purpose for existing drugs to suppress colon cancer metastasis, secure post-radiation brain function, and trick tumors

Drugs approved for treatment of specific maladies sometimes show unexpected benefits. Researchers at the 95th annual meeting of the American Association for Cancer Research demonstrated highlighted how some drugs may one day offer previously unforeseen benefits for patients.

30 Mar 2004

Trial of new drug that may halt progression of Type I Diabetes

The results of a long-term clinical trial on a new drug designed to inhibit the progression of type I diabetes was announced at the International Diabetes Society meeting in Cambridge, England, March 29. The findings of the 18-month long clinical trial confirm the drug's efficacy in improving a diabetic's ability to produce insulin.

30 Mar 2004

New Australian collaboration to discover new drugs targeting epilepsy and anxiety

Bionomics Limited and Southern Cross University announced today that they had established a collaboration to discover new drugs targeting epilepsy and anxiety. Under the arrangement, Southern Cross University will provide Bionomics with extracts from its collection of Australian-based natural products, together with expertise in natural products chemistry.

30 Mar 2004

Cancer research boosted in Queensland Australia

The University of Queensland's Institute for Molecular Bioscience (IMB) is one of just three recipients of the largest research grant ever given by the Australian Cancer Research Foundation (ACRF).

29 Mar 2004

Newly formed FAS Center for Systems Neuroscience

Harvard has long been recognized for its strength in neuroscience: Researchers in the Faculty of Arts and Sciences (FAS) are leaders in studies of behavior, perception, and brain development, while Harvard Medical School (HMS) was the first in the nation to establish a department of neurobiology.

29 Mar 2004

Comparative genomics to cast new light on other spirochete microbes

Three centuries after a pioneering Dutch microbiologist first observed the spiral-shaped oral pathogen Treponema denticola, scientists have deciphered the bacterium’s entire DNA sequence and used comparative genomics to cast new light on other spirochete microbes.

29 Mar 2004

A simple blood test could determine whether older women with diabetes would benefit from, or be harmed by, vitamin doses designed to protect their ailing hearts

A simple blood test could determine whether older women with diabetes would benefit from, or be harmed by, vitamin doses designed to protect their ailing hearts, according to researchers at the Technion-Israel Institute of Technology.

26 Mar 2004

p53 protein peptide stops cancer in its tracks

Researchers have dreamed of thwarting cancer by using proteins that halt cell growth and kill the tumor. In theory, the approach should work. In practice, however, scientists have not had an easy time of getting tumor suppressor proteins into cells where they can block growth effectively.

26 Mar 2004

Cryptosporidium parvum parasite could help to develope new therapies for the disease

Cryptosporidium parvum, an insidious, one-celled, waterborne parasite that lodges in the intestines of infected people and animals and for which there is currently no effective treatment, is missing key structures normally found in similar parasites, say researchers supported by the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health. The results of their genome sequencing project, could help scientists home in on new drug targets that may lead to therapies for the disease.

26 Mar 2004

Bionomics files novel angiogenesis genes patent

Bionomics Limited has announced that it had filed a further international patent application that covers 496 proprietary angiogenesis drug targets. The international patent application applies to genes that Bionomics has identified using advanced technologies such as microarray and bioinformatics analyses. These technologies have enabled Bionomics to identify novel angiogenesis genes that have not been identified by other companies or research groups.

26 Mar 2004

Researchers turn off individual human genes to study their function

Researchers have produced vast libraries of short segments of ribonucleic acid (RNA) that can be used to turn off individual human and mouse genes to study their function. The libraries will be made widely available to laboratories studying human biology and disease. The researchers are optimistic that the libraries will become a powerful research tool for gene analysis and discovery.

25 Mar 2004

Discovery of new gene sheds light on human brain development

With the identification of the gene responsible for a newly recognized type of mental retardation, researchers at Beth Israel Deaconess Medical Center (BIDMC) have also discovered what appears to be the key target in the evolution of the frontal lobes of the brain's cerebral cortex. The findings offer a key insight into the complex puzzle of human brain development - and the evolution of human behavior.

25 Mar 2004

Genes News and Research

Gene-rich human Chromosome 19 sequence completed

Research team has found a new way to streamline gene isolation to determine their functions

GenVec malaria vaccine initiative and the U.S. Naval Medical Research Center has announced partnership for malaria vaccine

Faster new cloning technique - transcript-based cloning

Scientists find parallels between human speech and bird song which gives clues to human speech disorders.

Zebrafish show effects of ionizing and UV radiation differ during embryo development

Discovery of novel gene profile that may identify colon stem cells

Extraction of RNA from Archived Formalin-Fixed, Paraffin-Embedded Tissue

Researchers find new purpose for existing drugs to suppress colon cancer metastasis, secure post-radiation brain function, and trick tumors

Trial of new drug that may halt progression of Type I Diabetes

New Australian collaboration to discover new drugs targeting epilepsy and anxiety

Cancer research boosted in Queensland Australia

Newly formed FAS Center for Systems Neuroscience

Comparative genomics to cast new light on other spirochete microbes

A simple blood test could determine whether older women with diabetes would benefit from, or be harmed by, vitamin doses designed to protect their ailing hearts

p53 protein peptide stops cancer in its tracks

Cryptosporidium parvum parasite could help to develope new therapies for the disease

Bionomics files novel angiogenesis genes patent

Researchers turn off individual human genes to study their function

Discovery of new gene sheds light on human brain development

eBook: Using iPSCs models for human disease research and drug discovery eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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