Immune System News and Research

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Scientists uncover an overlooked mechanism in the gut immune system of Crohn's disease patients

A team of scientists from DTU and other European universities have uncovered an overlooked mechanism in the gut immune system of patients suffering from severe cases of Crohn's disease.

13 Mar 2024

Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Targeting two brain tumor-associated proteins-;rather than one-;with CAR T cell therapy shows promise as a strategy for reducing solid tumor growth in patients with recurrent glioblastoma (GBM), an aggressive form of brain cancer, according to early results from the first six patients treated in an ongoing Phase I clinical trial led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

13 Mar 2024

Understanding how chikungunya virus affects the brain and body

The chikungunya virus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes and responsible for more than 900 deaths in Brazil since it arrived around ten years ago, is capable of spreading through the blood, reaching multiple organs and crossing the blood-brain barrier, which protects the central nervous system.

12 Mar 2024

NIH study uncovers vulnerable sites on Epstein-Barr virus protein

Studies of interactions between two lab-generated monoclonal antibodies (mAbs) and an essential Epstein-Barr virus (EBV) protein have uncovered targets that could be exploited in designing treatments and vaccines for this extremely common virus.

12 Mar 2024

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

Researchers from Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have uncovered thousands of previously unknown bile acids, a type of molecule used by our gut microbiome to communicate with the rest of the body.

12 Mar 2024

New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread

A newly developed "GPS nanoparticle" injected intravenously can home in on cancer cells to deliver a genetic punch to the protein implicated in tumor growth and spread, according to researchers from Penn State.

11 Mar 2024

LAG-3 protein structure may be the key to unlocking new cancer treatments

A molecular “snapshot” of a protein can be critical to understanding its function. Scientists at Stanford and NYU have published and investigated a new structure of the protein LAG-3 which could enable the development of new cancer treatments.

11 Mar 2024

Study highlights potential therapeutic target for immune-related disorders

A new study highlights a potential therapeutic target for immune-related disorders, such as multiple sclerosis and asthma.

11 Mar 2024

Researchers explore the role of vitamin A in pathogenesis of psychiatric disorders

A Newcastle research team has been exploring the role of vitamin A in the pathogenesis of psychiatric disorders.

11 Mar 2024

Immune cells in the liver eat up excess cholesterol, study reveals

A new study from Karolinska Institutet in Sweden reveals that immune cells in the liver react to high cholesterol levels and eat up excess cholesterol that can otherwise cause damage to arteries.

11 Mar 2024

Researchers develop precise drugs to target HIV's Nef protein

A team of University of Michigan researchers has successfully modified a naturally occurring chemical compound in the lab, resulting in advanced lead compounds with anti-HIV activity.

9 Mar 2024

Study reveals key mechanism of PD-1 function

Insights into the workings of an immune cell surface receptor, called PD-1, reveal how treatments that restrict its action can potentially be strengthened to improve their anticancer effect, a new study shows.

9 Mar 2024

Sleep boosts immune cell mobility toward lymph nodes

Researchers at LMU Munich have shown that sleep enhances the migratory potential of T cells toward lymph nodes.

8 Mar 2024

U-M research offers a new path forward in the development of anti-HIV drugs

A team of University of Michigan researchers has successfully modified a naturally occurring chemical compound in the lab, resulting in advanced lead compounds with anti-HIV activity.

8 Mar 2024

Tryptophan digestion by gut microbiome spurs arthritis inflammation

A University of Colorado Department of Medicine faculty member says she and her colleagues have identified the means in which bacteria in the digestive system can break down tryptophan in the diet into an inflammatory chemical that primes the immune system towards arthritis.

7 Mar 2024

Common age-associated changes in the blood found to be a risk factor for acute kidney injury

A U.S.-Canadian research collaboration led by Vanderbilt University Medical Center has identified common, age-associated changes in the blood as a risk factor for acute kidney injury (AKI), which occurs in more than 1 in 5 hospitalized adults worldwide.

7 Mar 2024

"Copy-paste" genetic mechanism increases the genetic diversity of malaria parasite

By dissecting the genetic diversity of the most deadly human malaria parasite – Plasmodium falciparum – researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) have identified a mechanism of 'copy-paste' genetics that increases the genetic diversity of the parasite at accelerated time scales.

7 Mar 2024

Study uncovers unexpected level of complexity hidden within neutrophils

In a study published in Cell on March 5, Prof. Zhang Xiaoming at the Shanghai Institute of Immunity and Infection (SIII) of the Chinese Academy of Sciences and Profs. Gao Qiang, Fan Jia and Yang Li at Fudan University have uncovered an unexpected level of complexity hidden within neutrophils, which were previously thought to be a relatively uniform population of short-lived immune cells.

6 Mar 2024

Metal organic frameworks enhance immune response in experimental vaccine

Many vaccines, including vaccines for hepatitis B and whooping cough, consist of fragments of viral or bacterial proteins.

6 Mar 2024

Simulation model predicts optimal COVID-19 booster frequency

Patients kept asking a question that Nathan Lo, MD, PhD, infectious disease specialist, had a hard time answering: How often should I get my booster shot for COVID-19?

6 Mar 2024

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Immune System News and Research

Scientists uncover an overlooked mechanism in the gut immune system of Crohn's disease patients

Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Understanding how chikungunya virus affects the brain and body

NIH study uncovers vulnerable sites on Epstein-Barr virus protein

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread

LAG-3 protein structure may be the key to unlocking new cancer treatments

Study highlights potential therapeutic target for immune-related disorders

Researchers explore the role of vitamin A in pathogenesis of psychiatric disorders

Immune cells in the liver eat up excess cholesterol, study reveals

Researchers develop precise drugs to target HIV's Nef protein

Study reveals key mechanism of PD-1 function

Sleep boosts immune cell mobility toward lymph nodes

U-M research offers a new path forward in the development of anti-HIV drugs

Tryptophan digestion by gut microbiome spurs arthritis inflammation

Common age-associated changes in the blood found to be a risk factor for acute kidney injury

"Copy-paste" genetic mechanism increases the genetic diversity of malaria parasite

Study uncovers unexpected level of complexity hidden within neutrophils

Metal organic frameworks enhance immune response in experimental vaccine

Simulation model predicts optimal COVID-19 booster frequency

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