Immune System News and Research

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Novel mechanisms controlling tertiary lymphoid structure formation in tumors revealed

Tertiary lymphoid structures are formations that occur outside of the lymphatic system. They contain immune cells and are similar in structure and function to lymph nodes and other lymphoid structures.

11 Jan 2022

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

Preliminary findings from Penn Medicine in an ongoing first-in-human clinical trial examining the safety, tolerability and feasibility of chimeric antigen receptor macrophage (CAR-M) has helped to establish the viability of this innovative immunotherapy, which advances the trailblazing scientific discovery of CAR T cell therapy- also pioneered at Penn- for solid cancer tumors and offers a promising new strategy in the fight against cancer.

11 Jan 2022

COVID-19 symptoms found to vary in different immune contexts

In a new study, researchers studied the kinetics of host response to SARS-CoV-2 infection in a Syrian hamster model, tracking disease pathology, viral loads, antibody responses, and inflammatory cytokine production in multiple organs.

11 Jan 2022

Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

Biliary atresia is a rare disease that occurs when a delicate tree-like set of ducts that carry bile from the liver to the intestine becomes scarred and blocked. While some treatments can slow the damage, most children who develop biliary atresia will die without a liver transplant.

10 Jan 2022

Researchers identify gene expression signatures linked to suicide risk

Is risk of suicide in our genes? Findings of an international scientific team led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that gene expression studies could offer insights into the underlying causes of suicide, a highly complex public health problem that takes the lives of more than 800,000 people each year worldwide.

10 Jan 2022

NCCN publishes new guidelines for managing patients with Graft-Versus-Host Disease

The National Comprehensive Cancer Network today announced the publication of new NCCN Guidelines for Patients: Graft-Versus-Host Disease (GVHD).

10 Jan 2022

Scientists unravel how blood cells mount the first line of defense against viruses

Scientists have just slotted into place a big piece of the puzzle that explains how our blood cells mount their first line of defense against viruses.

10 Jan 2022

Mapping regulatory T-cell populations in COVID-19 patients

In a new study, researchers used mass spectrometry to investigate changes to immune systems, in particular regulatory T-cells (Tregs), in a large cohort of moderate, severe, and critical Japanese coronavirus disease 2019 (COVID-19) patients and healthy controls.

10 Jan 2022

New molecule offers effective protection against coronavirus for at least eight hours

A molecule developed by researchers at the University of Helsinki can inactivate the coronavirus spike protein and offers effective short-term protection against the virus.

10 Jan 2022

Emerging SARS-CoV-2 B.1.619 and B.1.620 variants in South Korea

Researchers investigate the spread and transmission ability of SARS-CoV-2 lineages B.1.619 and B.1.620 in South Korea.

9 Jan 2022

SARS-CoV-2 Omicron a product of offensive evolution with compromised antigenicity

Researchers investigate the relationship between the SARS-CoV-2 Omicron variant and immune system based on self/nonself short constituent sequences.

9 Jan 2022

Study shows probiotics can reduce symptoms of COVID-19 when taken post-exposure

A new study shows how a daily use of Lactobacillus rhamnosus GG (LGG) probiotic may protect against symptom development in instances when it is used as post-exposure prophylaxis within seven days after exposure to severe acute respiratory syndrome coronavirus 2.

7 Jan 2022

Broad cross-neutralization antibodies found to be effective against SARS-CoV-2 Omicron variant

A new study aimed to explore whether there is a way to induce the production of potent neutralizing antibodies capable of neutralizing all SARS-CoV-2 variants - including Omicron.

7 Jan 2022

Moderna announces initiation of Phase 1 study of its mRNA-1189 EBV vaccine candidate

Moderna, Inc., a biotechnology company pioneering messenger RNA therapeutics and vaccines, today announced the first participant has been dosed in the Phase 1 study of mRNA-1189, the Company's Epstein-Barr Virus vaccine candidate.

7 Jan 2022

Grouping tumors by 'immune archetypes' points the way to personalized immunotherapies

The UCSF researchers, led by first co-authors Alexis Combes, PhD, and Bushra Samad, MS, and senior author, Max Krummel, PhD, obtained tumor specimens from 78 UCSF clinicians, and surveyed 364 tumors biopsies from patients and categorized them into groups based on their immune microenvironment.

7 Jan 2022

Immune System News and Research

Novel mechanisms controlling tertiary lymphoid structure formation in tumors revealed

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

COVID-19 symptoms found to vary in different immune contexts

Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

Researchers identify gene expression signatures linked to suicide risk

NCCN publishes new guidelines for managing patients with Graft-Versus-Host Disease

Scientists unravel how blood cells mount the first line of defense against viruses

Mapping regulatory T-cell populations in COVID-19 patients

New molecule offers effective protection against coronavirus for at least eight hours

Emerging SARS-CoV-2 B.1.619 and B.1.620 variants in South Korea

SARS-CoV-2 Omicron a product of offensive evolution with compromised antigenicity

Study shows probiotics can reduce symptoms of COVID-19 when taken post-exposure

Broad cross-neutralization antibodies found to be effective against SARS-CoV-2 Omicron variant

Moderna announces initiation of Phase 1 study of its mRNA-1189 EBV vaccine candidate

Grouping tumors by 'immune archetypes' points the way to personalized immunotherapies

Researchers study immune cell invasion process in living fruit fly embryos

Study reinforces the link between microglia and some cases of brain disease

Study identifies current mechanism of action behind reduced severity of Omicron variant COVID-19 infection

Efficacy of COVID-19 convalescent plasma therapy in patients with hematological malignancies and COVID-19

Oral bacteria-based SARS-CoV-2 vaccine platform

Immunology eBook

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

Automating research - solutions and best practices

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