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ART may not be completely effective in restoring immune protection, study suggests

A study led by researchers from SUNY Downstate Health Sciences University and Oregon Health & Science University, published in the Journal of Infectious Diseases, showed that, despite successful antiretroviral therapy, antigen specific memory to vaccinations that occurred before HIV infection did not recover, even after immune reconstitution.

6 Jan 2020

Lab-grown brain organoids may hold the answers to personalized treatments for glioblastomas

Lab-grown brain organoids developed from a patient's own glioblastoma, the most aggressive and common form of brain cancer, may hold the answers on how to best treat it.

26 Dec 2019

Targeted screening effective in reducing prostate cancer deaths

A new study published in the journal PLOS Medicine shows that the number of prostate cancer deaths could be reduced by a sixth by simply introducing targeted screening, which is directed at detecting cases among men whose genes put them at higher risk of the disease.

22 Dec 2019

New research could lead to an improved vaccine to protect against meningococcal infections

New research from experts at the University of Nottingham could lead to an improved vaccine to protect against the bacterium, Neisseria meningitides that causes sepsis and meningitis.

22 Dec 2019

Target at-risk patients for prostate cancer screening, say experts

Almost one in six deaths from prostate cancer could be prevented if targeted screening was used for men at a higher genetic risk for the disease.

20 Dec 2019

Science has not been able to create a substitute for human blood

Science has been able to create and employ a number of medical marvels, such as the artificial heart and synthetic insulin. But not a substitute for human blood.

19 Dec 2019

New paper-based test for early Lyme diagnosis

A new paper in the journal ACS Nano reports the development of an incredibly cheap and highly sensitive test to diagnose Lyme disease in its earliest stages, when it can be most easily, effectively and inexpensively treated.

18 Dec 2019

Scientists explore role of IgG4 Abs in IgG4-related disease

Autoimmune diseases are a medical conundrum. In people with these conditions, the immune system of the body, the designated defense system, starts attacking the cells or organs of its own body, mistaking the self-cells for invading disease-causing cells. Often, the cause for this spontaneous dysfunction is not clear, and hence, treatment of these diseases presents a major and ongoing challenge.

18 Dec 2019

New combination therapy can lead to durable responses in patients with multiple myeloma

An experimental, off-the-shelf immunotherapy that combines a targeted antibody and chemotherapy can lead to potentially durable responses in multiple myeloma patients whose disease has relapsed or is resistant to other standard therapies.

17 Dec 2019

The sympathetic nervous system can modulate action of defense cells in autoimmune disease

The results of a study conducted in Brazil suggest that the sympathetic nervous system - the part of the autonomous nervous system that controls responses to danger or stress - can modulate the action of defense cells in patients with autoimmune diseases.

16 Dec 2019

Novel and targeted cellular product causes cell death in non-Hodgkin lymphoma models

Investigators at Rutgers Cancer Institute of New Jersey have found that a treatment based on a novel cellular product programmed to deliver an overabundance of chimeric antigen receptor causes cell death in non-Hodgkin lymphoma models that are sensitive or resistant to standard therapies.

16 Dec 2019

Immune cells repair damaged gut in children with IBD

According to a new study published in the journal Gastroenterology, immune cells of a certain kind which regulate inflammatory processes and even help restore normal gut function after inflammation could be of great use to treat children with inflammatory bowel disease (IBD).

11 Dec 2019

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

New findings from a clinical trial show that treatment with the immunotherapy drug blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia that has relapsed.

10 Dec 2019

Risk of specific genetic translocation is higher in patients of African ancestry, shows study

Multiple myeloma is a plasma cell cancer that is more common in patients of African American descent than of European American descent.

10 Dec 2019

Relapsed mantle cell lymphoma patients may benefit from CAR T-cell therapy

A one-year follow-up study led by The University of Texas MD Anderson Cancer Center revealed a majority of patients with mantle cell lymphoma resistant to prior therapies may benefit from treatment with CD19-targeting chimeric antigen receptor (CAR) T-cell therapy.

9 Dec 2019

Small, thin metal mesh loaded with T cells shrinks tumors in ovarian cancer models

New findings published Dec. 9 in Nature Biomedical Engineering from scientists at Fred Hutchinson Cancer Research Center show for the first time that a piece of small, thin metal mesh loaded with cancer-fighting immune cells shrinks tumors in preclinical models of ovarian cancer.

9 Dec 2019

New approach to broadly acting, highly effective HIV vaccine

Researchers have reported a major advance in the creation of a successful HIV vaccine that is not produced by the host animal.

9 Dec 2019

New approach can improve the activity of CAR-T cells against blood and solid cancers

A new approach to programing cancer-fighting immune cells called CAR-T cells can prolong their activity and increase their effectiveness against human cancer cells grown in the laboratory and in mice, according to a study by researchers at the Stanford University School of Medicine.

5 Dec 2019

Epigenomic techniques used to fight disease

Humans differ from one another in many ways, including how they react to disease, because of their DNA blueprint, as well as the difference in the environments they face. These factors combine to make each person unique. Now a new study published in the journal Nature Protocols reports the development of a promising technology to uncover the process by which the body fights diseases in different ways.

4 Dec 2019

Transitional T cells could help improve cancer immunotherapy

In chronic viral infections and cancer, T cell dysfunction is sure to be observed. A new study to be published in the journal Immunity shows that before these cells are completely exhausted, there is a transitory stage in which some cells are present with features that are characteristic of neither the stem-like T cells nor the mature but exhausted T cells.

4 Dec 2019

Antigen News and Research

ART may not be completely effective in restoring immune protection, study suggests

Lab-grown brain organoids may hold the answers to personalized treatments for glioblastomas

Targeted screening effective in reducing prostate cancer deaths

New research could lead to an improved vaccine to protect against meningococcal infections

Target at-risk patients for prostate cancer screening, say experts

Science has not been able to create a substitute for human blood

New paper-based test for early Lyme diagnosis

Scientists explore role of IgG4 Abs in IgG4-related disease

New combination therapy can lead to durable responses in patients with multiple myeloma

The sympathetic nervous system can modulate action of defense cells in autoimmune disease

Novel and targeted cellular product causes cell death in non-Hodgkin lymphoma models

Immune cells repair damaged gut in children with IBD

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

Risk of specific genetic translocation is higher in patients of African ancestry, shows study

Relapsed mantle cell lymphoma patients may benefit from CAR T-cell therapy

Small, thin metal mesh loaded with T cells shrinks tumors in ovarian cancer models

New approach to broadly acting, highly effective HIV vaccine

New approach can improve the activity of CAR-T cells against blood and solid cancers

Epigenomic techniques used to fight disease

Transitional T cells could help improve cancer immunotherapy

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