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Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

Through extensive single-cell analysis, researchers at The University of Texas MD Anderson Cancer Center have created a spatial map of tumor-infiltrating B cells and plasma cells in early-stage lung cancers, highlighting previously unappreciated roles these immune cells play in tumor development and treatment outcomes.

13 Sep 2022

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Up to three quarters of patients receiving cancer chemotherapy suffer from "chemo brain" -; a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, whose brains are still developing, their schoolwork and self-esteem may suffer.

13 Sep 2022

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Researchers at Johns Hopkins Medicine report that an experimental drug first developed to treat kidney disease prolongs survival and improves muscle function in mice genetically engineered to develop a severe form of Duchenne muscular dystrophy (DMD).

13 Sep 2022

Discoveries about embryonic blood stem cell creation may solve donor blood stem cell shortages

Making stem cells from a patient’s adult cells – rather than human embryos – is one of the holy grails in modern medicine treatments. New research brings us two steps closer.

13 Sep 2022

What is the effectiveness of tecovirimat for treatment of monkeypox?

Researchers assessed the effectiveness of tecovirimat in monkeypox treatment in a new study.

13 Sep 2022

Brain organoids shed light into the evolution of the human brain

Animal studies on great apes have long been banned in Europe for ethical reasons. For the question pursued here, so-called organoids, i.e. three-dimensional cell structures a few millimeters in size that are grown in the laboratory, are an alternative to animal experiments.

13 Sep 2022

Molecular explanation for the contribution of autophagy to BAT energy metabolism

Obesity is a growing global health problem and its prevalence has tripled since 1975. More than 650 million people are affected by this condition worldwide, and 28% of people in Spain over 18 years of age have this complex pathology. Obesity is linked to conditions such as type II diabetes, cardiovascular disease, osteoarthritis, and certain forms of cancer.

13 Sep 2022

False positive monkeypox tests in low-risk patients with no exposures

Researchers reported three monkeypox diagnoses presenting atypical rashes.

13 Sep 2022

Study investigates BMI, race, and lung cancer diagnosis relationships

Lung cancer is the leading cause of cancer death in the US, making up 25% of cancer deaths. With obesity rates simultaneously rising, researchers have investigated the connections between cancer risk and body mass index (BMI). Unlike most other cancer types, where higher BMI is associated with increased risk of cancer, research has established that paradoxically people with higher BMI have lower rates of lung cancer diagnosis.

13 Sep 2022

Researchers uncover the structure of protein fibrils linked to hereditary form of human prion disease

In a new study, researchers from the Case Western Reserve University School of Medicine have identified the structure of protein fibrils linked to a hereditary form of human prion disease.

12 Sep 2022

Targeting the Notch pathway with gamma secretase inhibitor improves outcomes in patients with rare cancers

Significant improvement in progression-free survival and response rate combined with reduced symptoms and better quality of life are reported as outcomes of a new treatment approach for patients with desmoid tumors, which are benign, but locally aggressive and invasive soft tissue tumors.

12 Sep 2022

Exercise hormone reduces protein levels linked to Parkinson's disease

Researchers from Johns Hopkins Medicine and the Dana Farber Cancer Institute in Boston have shown that a hormone secreted into the blood during endurance, or aerobic, exercise reduces levels of a protein linked to Parkinson's disease and halts movement problems in mice.

12 Sep 2022

Research could lead to a new therapeutic option for patients with bladder cancer

Mount Sinai researchers have made two important discoveries about the mechanism by which bladder cancer cells foil attacks from the immune system.

12 Sep 2022

Study reveals two distinct types of obesity with physiological and molecular differences

A team led by Van Andel Institute scientists has identified two distinct types of obesity with physiological and molecular differences that may have lifelong consequences for health, disease and response to medication.

12 Sep 2022

UQ researchers receive international funding to combat melanoma in US troops

Researchers at The University of Queensland have been awarded international funding to combat an expected escalation of skin cancer cases in US troops who served in Iraq and Afghanistan.

12 Sep 2022

Monkeypox in the WHO European region: epidemiological features, disease severity, and the impact of smallpox vaccination

A new study aimed to analyze the epidemiological features of MPX, disease severity, as well as the impact of smallpox vaccination on all infected cases reported in the WHO European Region.

12 Sep 2022

The ongoing 2022 West Nile virus transmission season in Italy

A recent article described the seasonal transmission of the West Nile virus in 2022 and compared the human cases reported in June-July 2022 with the reports in 2018.

12 Sep 2022

The prevalence and spectrum of neurological and psychiatric presentations of human monkeypox infection

Scientists have conducted a systematic review and meta-analysis to evaluate the prevalence of neuropsychiatric manifestations associated with monkeypox infection.

12 Sep 2022

Children become more skeptical of what adults tell them, study says

Children learn on their own through observation and experimentation. They also learn from what other people tell them, especially adults and authority figures like their parents and teachers. When children learn something surprising, they seek out additional information by asking questions or by testing claims. Prior research shows that whether children explore adults' surprising claims varies by age, with children over six years of age more likely to seek out additional information than four- and five-year-olds.

12 Sep 2022

Tumor-infiltrating lymphocytes therapy treats cancers at a large scale

A novel treatment strategy with personalized cell therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma, according to ground-breaking results reported at the ESMO Congress 2022 from the phase 3 M14TIL trial.

12 Sep 2022

Laboratory News and Research

Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Discoveries about embryonic blood stem cell creation may solve donor blood stem cell shortages

What is the effectiveness of tecovirimat for treatment of monkeypox?

Brain organoids shed light into the evolution of the human brain

Molecular explanation for the contribution of autophagy to BAT energy metabolism

False positive monkeypox tests in low-risk patients with no exposures

Study investigates BMI, race, and lung cancer diagnosis relationships

Researchers uncover the structure of protein fibrils linked to hereditary form of human prion disease

Targeting the Notch pathway with gamma secretase inhibitor improves outcomes in patients with rare cancers

Exercise hormone reduces protein levels linked to Parkinson's disease

Research could lead to a new therapeutic option for patients with bladder cancer

Study reveals two distinct types of obesity with physiological and molecular differences

UQ researchers receive international funding to combat melanoma in US troops

Monkeypox in the WHO European region: epidemiological features, disease severity, and the impact of smallpox vaccination

The ongoing 2022 West Nile virus transmission season in Italy

The prevalence and spectrum of neurological and psychiatric presentations of human monkeypox infection

Children become more skeptical of what adults tell them, study says

Tumor-infiltrating lymphocytes therapy treats cancers at a large scale

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