Amyotrophic Lateral Sclerosis News and Research

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UK-wide trial aims to find treatments that can slow or reverse MND

Hundreds of people living with motor neurone disease are being invited to take part in one of the UK's most comprehensive clinical trials in a generation.

16 Jan 2020

Study identifies molecular 'bridge' between ALS-causing genes

The enzyme Gemin3 was identified as the molecular 'bridge' between genes whose mutation or disruption causes amyotrophic lateral sclerosis, according to a new study in Nature's Scientific Reports from scientists at the University of Malta.

16 Jan 2020

Horizon Discovery to offer novel base editing technology for clinical research

Horizon Discovery today announced that it will provide access to a novel base editing technology licensed from Rutgers for exclusive use in therapeutic, diagnostic and services applications.

From Revvity 14 Jan 2020

New screening platform helped scientists to discover drug-like compounds

A sophisticated new screening platform developed by scientists at Scripps Research has enabled them to discover a set of drug-like compounds, including an ingredient found in sore throat lozenges, that may powerfully protect brain cells from dangerous stresses found in Alzheimer's and other neurodegenerative diseases.

9 Jan 2020

Research project leverages big data to close the gap on cognitive decline and healthy aging

A new research project at the University of Arizona Center for Innovation in Brain Science will apply a big-data approach, using bioinformatics and computational modeling, to better understand the systems biology of Alzheimer's and other neurodegenerative diseases.

8 Jan 2020

A new kind of testing for patients with Parkinson's disease

Parkinson's disease is a neurodegenerative disorder that manifests through symptoms such as tremor, slow movements, limb rigidity and gait and balance problems.

26 Dec 2019

Research findings may one day help keep ALS at bay

A new study published in the journal Nature Medicine on December 23, 2019, shows how to silence a defective gene responsible for the degeneration of the motor neurons in Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS), in adult mice. This could help prevent disease progression if the condition is already symptomatic, and even suppress the illness if it has not yet started.

23 Dec 2019

Could high cholesterol lead to motor neuron disease?

Researchers suggest that motor neuron disease may be linked to an abnormal build-up of cholesterol and other lipids within cellular compartments.

20 Dec 2019

The role of adenosine in neurodegeneration and brain regeneration

The role of adenosine in neurodegeneration and neuroregeneration has led to growing attention on adenosine receptors as potential drug targets in a range of brain disorders, including neuroregenerative therapy and treatment for amyotrophyic lateral sclerosis.

8 Dec 2019

FDA-approved anti-inflammatory drug delays onset of ALS in mice

The cause of amyotrophic lateral sclerosis (ALS)--a disabling neurodegenerative disease that affects nerve cells in the brain and spinal cord and leads to weakened muscles and early death--is not fully understood, but accumulating evidence suggests that inflammatory processes may play a role in the initiation and progression of the condition.

27 Nov 2019

Stem cells do not take the day off on national holidays

While most of us are stuffing ourselves with turkey and pumpkin pie at home on Thanksgiving Day, the staff at one Cedars-Sinai laboratory will be on the job, feeding stem cells.

26 Nov 2019

BrainStorm publishes NurOwn ALS Phase 2 randomized clinical trial results in Neurology

BrainStorm Cell Therapeutics Inc., a leader in the development of innovative autologous cellular therapies for highly debilitating neurodegenerative diseases, today announced publication of "NurOwn Phase 2 Randomized Clinical Trial in ALS: Safety, Clinical and BioMarker Results," in the international, peer-reviewed journal Neurology.

20 Nov 2019

Thermo Scientific Aquilos 2 Cryo-FIB reduces sample preparation time

Thermo Fisher Scientific today announced the Thermo Scientific Aquilos 2 Cryo-FIB, a DualBeam system dedicated to the preparation of thin, electron-transparent samples from biological specimens.

From Thermo Fisher Scientific – Electron Microscopy Solutions 11 Nov 2019

Study shows how myelinated mammalian nerves propagate nerve impulses at high frequencies

University of Alabama at Birmingham researchers, for the first time ever, have achieved patch-clamp studies of an elusive part of mammalian myelinated nerves called the Nodes of Ranvier.

6 Nov 2019

TDP-43 study could speed up the diagnosis and treatment of ALS

A new study suggests that TDP-43 may be used as a biomarker in the diagnosis and treatment of amyotrophic lateral sclerosis (ALS).

30 Oct 2019

NCATS funds 'All of Us Research Program' to evaluate innovative DNA sequencing tools

The All of Us Research Program has selected the HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, to evaluate the use of leading-edge DNA sequencing technologies that could someday improve diagnosis and treatment of many diseases, both common and rare.

18 Oct 2019

New research center will encompass a myriad of muscle science and disease investigations

With collaborating labs across the University of Washington campus and at other Seattle-area institutions and beyond, the Center for Translational Muscle Research will encompass a myriad of muscle science and disease investigations.

17 Oct 2019

Improved antibody validation

Antibodies are used in a variety of clinical and research situations to examine the structure and function, and distribution of proteins. However, many researchers have found a lack of specificity in the functioning of these antibodies. This means that any work conducted using these antibodies will not yield reliable results.

16 Oct 2019

ALS patients with commonly inherited genetic variation may experience more severe symptoms

A discovery made several years ago in a lab researching asthma at Wake Forest School of Medicine may now have implications for the treatment of amyotrophic lateral sclerosis (ALS), a disease with no known cure and only two FDA-approved drugs to treat its progression and severity.

16 Oct 2019

Research may help explain how liquid organelles in cells coexist without merging

New research may help to explain an intriguing phenomenon inside human cells: how wall-less liquid organelles are able to coexist as separate entities instead of just merging together.

10 Oct 2019