Immune System News and Research

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Unlocking the secrets of T follicular helper cells for better treatment strategies

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer.

1 Mar 2024

Scientists discover a key mechanism used by human herpesvirus 8 to induce cancer

Cleveland Clinic researchers have discovered a key mechanism used by Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), to induce cancer.

1 Mar 2024

Loneliness negatively affects the physical health of older adults

The loneliness often experienced by older people in our society has a negative effect on their physical health, according to researchers from Amsterdam UMC and the University of Glasgow. Emiel Hoogendijk, epidemiologist at Amsterdam Public Health, analyzed research results from more than 130 studies and found that loneliness led to an increase in physical frailty, which in turn increases the risk of adverse health outcomes such as depression, falls and cognitive decline.

29 Feb 2024

Breakthrough CRISPR technique unlocks insights about cancer immunology

Over the past two decades, the immune system has attracted increasing attention for its role in fighting cancer.

29 Feb 2024

New approach detects T cells in "cold" tumors, paves way for broader immunotherapy

Most cancers are thought to evade the immune system. These cancers don't carry very many mutations, and they aren't infiltrated by cancer-fighting immune cells. Scientists call these cancers immunologically "cold."

29 Feb 2024

EPFL scientists uncover protein degradation mechanism preventing autoimmune reactions

Scientists at EPFL uncover the mechanism by which cells mark the protein cGAS for degradation, which is critical in preventing the immune system from mistakenly attacking the body's own tissues.

28 Feb 2024

Uncovering the role of mucus in pancreatic cancer transformation

Knowing exactly what's inside a tumor can maximize our ability to fight cancer. But that knowledge doesn't come easy. Tumors are clusters of constantly changing cancer cells.

28 Feb 2024

Novel drug combination shows promise for treating advanced skin cancers in kidney transplant recipients

People who have had a kidney transplant are at high risk for developing skin cancers. New research directed by investigators from the Johns Hopkins Kimmel Cancer Center is exploring the best combination of treatments to target skin cancers while preserving the transplanted organs.

28 Feb 2024

Novel brain organoid model unveils link between inflammation and astrocyte dysfunction

The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain.

28 Feb 2024

UMass Amherst study targets aplastic anemia with cell retraining approach

Researchers at the University of Massachusetts Amherst recently released a first-of-its-kind study that focuses on the rare autoimmune disorder aplastic anemia to understand how a subset of cells might be trained to correct the overzealous immune response that can lead to fatal autoimmune disorders.

27 Feb 2024

Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages

A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in the top-class journal Cellular & Molecular Immunology, has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs) and thus on tumor growth.

27 Feb 2024

Boston College biologist wins NIH grant to study viral insulins for cancer treatment

Boston College Assistant Professor of Biology Emrah Altindis has been awarded a five-year, $2.5-million grant from the National Institutes of Health to study viral insulins and mechanisms related to IGF-1 receptor protein inhibition and its potential applications in cancer treatment.

26 Feb 2024

Innovative therapy targets and destroys leukemia stem cells

Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have devised an innovative approach to target and destroy hard-to-kill leukemia stem cells.

26 Feb 2024

New clinical practice guideline offers evidence-based recommendations for managing inhalant allergies with immunotherapy

The American Academy of Otolaryngology–Head and Neck Surgery Foundation published the Clinical Practice Guideline: Immunotherapy for Inhalant Allergy today in Otolaryngology–Head and Neck Surgery.

26 Feb 2024

Study: Antibody combination shows safety and anti-tumor activity in advanced cancer patients

In an early phase clinical trial, a combination of antibody-based medications targeting the immune system generated promising safety data and anti-tumor activity in individuals with various types of advanced cancer.

26 Feb 2024

Omalizumab shows promise in preventing food allergy reactions in children, study finds

A drug can make life safer for children with food allergies by preventing dangerous allergic responses to small quantities of allergy-triggering foods, according to a new study led by scientists at the Stanford School of Medicine.

25 Feb 2024

Newborn T cells found to excel in immune defense

Scientists have long believed that a newborn's immune system was an immature version of an adult's, but new research from Cornell University shows that newborns' T cells – white blood cells that protect from disease – outperform those of adults at fighting off numerous infections.

24 Feb 2024

Researchers develop promising recombinant flu vaccine using nanoliposome technology

Recombinant protein vaccines, like the Novavax vaccine used to fight COVID-19, offer several advantages over conventional vaccines.

24 Feb 2024

Identifying antiviral protein IFN-γ as a potential biomarker for Long COVID

SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in Long COVID patients, IFN-y production persists until symptoms improve, highlighting a potential biomarker and a target for therapies.

24 Feb 2024

Unlocking vitamin B6's role in pancreatic cancer and immune system battle

Vitamin B6 is beneficial in many ways, notably for its role in maintaining a strong immune system. However, when pancreatic cancer develops, its cells also need vitamin B6 to replicate.

23 Feb 2024

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Immune System News and Research

Unlocking the secrets of T follicular helper cells for better treatment strategies

Scientists discover a key mechanism used by human herpesvirus 8 to induce cancer

Loneliness negatively affects the physical health of older adults

Breakthrough CRISPR technique unlocks insights about cancer immunology

New approach detects T cells in "cold" tumors, paves way for broader immunotherapy

EPFL scientists uncover protein degradation mechanism preventing autoimmune reactions

Uncovering the role of mucus in pancreatic cancer transformation

Novel drug combination shows promise for treating advanced skin cancers in kidney transplant recipients

Novel brain organoid model unveils link between inflammation and astrocyte dysfunction

UMass Amherst study targets aplastic anemia with cell retraining approach

Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages

Boston College biologist wins NIH grant to study viral insulins for cancer treatment

Innovative therapy targets and destroys leukemia stem cells

New clinical practice guideline offers evidence-based recommendations for managing inhalant allergies with immunotherapy

Study: Antibody combination shows safety and anti-tumor activity in advanced cancer patients

Omalizumab shows promise in preventing food allergy reactions in children, study finds

Newborn T cells found to excel in immune defense

Researchers develop promising recombinant flu vaccine using nanoliposome technology

Identifying antiviral protein IFN-γ as a potential biomarker for Long COVID

Unlocking vitamin B6's role in pancreatic cancer and immune system battle

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