Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Severity of COVID-19 symptoms is reflected by higher levels of chemical biomarker

Varying severity of COVID-19 symptoms in patients is reflected by levels of a chemical biomarker in their body which scientists say could be used to better manage treatments and other interventions, including vaccinations.

19 Apr 2021

Five-year study aims to improve health of patients with cystic fibrosis across their growing lifespan

People with cystic fibrosis are living better and longer, and now investigators want to further enhance quality and longevity by better understanding the role of nutrition, body composition and exercise in their health across an increasing lifespan.

19 Apr 2021

SARS-CoV-2 can alter bone marrow macrophage (BMM)-to-osteoclast differentiation, study finds

Now, a team of researchers in China and Australia has shown that SARS-CoV-2 infection can affect bone marrow macrophage (BMM)-to-osteoclast differentiation, which may impact the skeletal system.

16 Apr 2021

Complex patterns of genetic ancestry can provide insights into genetic, environmental factors of many diseases

The complex patterns of genetic ancestry uncovered from genomic data in health care systems can provide valuable insights into both genetic and environmental factors underlying many common and rare diseases--insights that are far more targeted and specific than those derived from traditional ethnic or racial labels like Hispanic or Black, according to a team of Mount Sinai researchers.

16 Apr 2021

Researchers identify two distinct phenotypes of COVID-19-associated ARDS

Approximately one in four patients hospitalized for the acute respiratory distress syndrome (ARDS) associated with severe COVID-19 infections may have a distinct phenotype (disease presentation) or biochemical profile associated with organ dysfunction, blood-clotting abnormalities and greater risk of death than patients with other, seemingly similar forms of the disease, researchers at Massachusetts General Hospital have found.

15 Apr 2021

Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

Researchers from Kumamoto University have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis.

15 Apr 2021

Pregnancy increases the risk of first-time symptomatic kidney stone

Though researchers have long known that several physiological and anatomical changes occur during pregnancy that can contribute to kidney stone formation, evidence of the link has been lacking. But now Mayo Clinic researchers believe they have that evidence.

15 Apr 2021

Doctors warn about the potential cardiovascular dangers of energy drink consumption

Heavy energy drink consumption may be linked to heart failure, doctors have warned in the journal BMJ Case Reports after treating a 21 year old, who had regularly drunk 4 such cans every day for around 2 years.

15 Apr 2021

The FDA seeks a new way to review old drugs without causing prices to soar

Chuck Peterson of Omaha, Nebraska, recently experienced a swollen, painful knuckle caused by arthritis. He got a prescription for colchicine.

15 Apr 2021

Series of reviews discuss key issues in chronic kidney disease and bone disorders

Metabolic bone disease is a common complication of chronic kidney disease (CKD) and involves a broad spectrum of disorders of mineral metabolism that result in both skeletal and extra-skeletal consequences.

15 Apr 2021

COVID-19 deadlier than cars for over 40s, study finds

The study, which appeared on the pre-print server medRxiv, presented mortality rates and case-fatality rates for COVID-19 compared with other historic leading causes of death in the United States.

15 Apr 2021

Study identifies differences in biomarkers of inflammation between novel diabetes subgroups

Chronic inflammation is increasingly a focus of research. A recent study has now identified differences in indicators of inflammation between novel diabetes subgroups. But what does this mean for the future?

15 Apr 2021

Early monoclonal antibody therapies beneficial for COVID-19, finds study

A team of scientists recently conducted a large-scale study at Northwell Health, New York, USA, to evaluate the efficacy of neutralizing monoclonal antibody (MAB) therapies in preventing disease progression among patients with mild to moderate COVID-19. The findings reveal that the timing of initiating MAB therapy is a crucial factor in determining its efficacy against COVID-19.

14 Apr 2021

Study demonstrates that the main creators of SARS-CoV-2 mutations are vaccine-suppressed

A new research paper posted to the medRxiv* preprint server describes the changes in genomic sequence observed during the course of infection in a patient on the drug tacrolimus, along with steroids, both potent immunosuppressants, and who also received convalescent plasma treatment. These mutations were observed to occur within three weeks from infection.

14 Apr 2021

Chemical modification of RNA appears to play a critical role in inherited kidney disorder

A chemical modification of RNA that can be influenced by diet appears to play a key role in polycystic kidney disease, an inherited disorder that is the fourth leading cause of kidney failure in the U.S., UT Southwestern researchers report in a new study.

13 Apr 2021

New research could change how doctors treat some patients with high blood pressure

New research led by a professor at NUI Galway is set to change how doctors treat some patients with high blood pressure - a condition that affects more than one in four men and one in five women.

13 Apr 2021

Baseline brain imaging should be considered in most metastatic kidney cancer patients, study suggests

The April 2021 issue of JNCCN-;Journal of the National Comprehensive Cancer Network publishes new research from Memorial Sloan Kettering Cancer Center (MSK) and Gustave Roussy Institute, which suggests that baseline brain imaging should be considered in most patients with metastatic kidney cancer.

13 Apr 2021

ACE2 homology in laboratory and wild animals

A new preprint research paper posted to the bioRxiv server describes the conservation of an important receptor gene for the virus among several animal species that live in close contact or proximity to humans.

13 Apr 2021

Study uncovers molecular reason why fecal transplants effectively treat C. difficile infections

Experts have uncovered a new molecular reason why faecal transplants are highly effective in treating infections such as C. difficile (a nasty bacteria that can infect the bowel), which could lead to more targeted treatments for this and other similar diseases.

9 Apr 2021

Removing race modifiers in equations used to estimate kidney function

The American Society of Nephrology and the National Kidney Foundation announce the concurrent publication of "Special Article: Reassessing the Inclusion of Race in Diagnosing Kidney Diseases: An Interim Report from the NKF-ASN Task Force" in the Journal of the American Society of Nephrology and the American Journal of Kidney Diseases.

9 Apr 2021

Nephrology News and Research

Further Reading

Severity of COVID-19 symptoms is reflected by higher levels of chemical biomarker

Five-year study aims to improve health of patients with cystic fibrosis across their growing lifespan

SARS-CoV-2 can alter bone marrow macrophage (BMM)-to-osteoclast differentiation, study finds

Complex patterns of genetic ancestry can provide insights into genetic, environmental factors of many diseases

Researchers identify two distinct phenotypes of COVID-19-associated ARDS

Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

Pregnancy increases the risk of first-time symptomatic kidney stone

Doctors warn about the potential cardiovascular dangers of energy drink consumption

The FDA seeks a new way to review old drugs without causing prices to soar

Series of reviews discuss key issues in chronic kidney disease and bone disorders

COVID-19 deadlier than cars for over 40s, study finds

Study identifies differences in biomarkers of inflammation between novel diabetes subgroups

Early monoclonal antibody therapies beneficial for COVID-19, finds study

Study demonstrates that the main creators of SARS-CoV-2 mutations are vaccine-suppressed

Chemical modification of RNA appears to play a critical role in inherited kidney disorder

New research could change how doctors treat some patients with high blood pressure

Baseline brain imaging should be considered in most metastatic kidney cancer patients, study suggests

ACE2 homology in laboratory and wild animals

Study uncovers molecular reason why fecal transplants effectively treat C. difficile infections

Removing race modifiers in equations used to estimate kidney function

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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