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Wistar researchers find potential way for using STAT3 inhibitors to stop cancer progression

Imagine developing a drug designed to inhibit a protein that helps cancer cells proliferate and survive only to find that the drug does not perform very well in the clinic. This was the dilemma faced by scientists researching inhibitors of signal transducer and activator of transcription (STAT3), a protein that controls transcription by the STAT3 gene.

17 Feb 2016

Better understanding link between oral bacteria and certain types of stroke

In a study of patients entering the hospital for acute stroke, researchers have increased their understanding of an association between certain types of stroke and the presence of the oral bacteria (cnm-positive Streptococcus mutans).

17 Feb 2016

Vascular surgery safer than stenting for older patients with carotid stenosis

Vascular surgery appears to be safer than stenting for patients over 70 years of age with carotid stenosis, or a blockage of the carotid arteries in the neck, according to new findings published today in the Lancet.

16 Feb 2016

Researchers identify how Toxoplasma parasite crosses blood-brain barrier

An estimated 30 percent of the world's population is chronically infected with the parasite Toxoplasma gondii. Most people live with the infection without noticeable effect, but it can be life-threatening for people with suppressed immune systems, such as people on cancer therapies or who have HIV/AIDS.

16 Feb 2016

Variations in Tie2 gene play significant role in patient responses to infections

Major infections such as influenza and bacterial sepsis kill millions of people each year, often resulting fro dangerous complications that impair the body's blood vessels. But the reasons why some patients experience these dramatic responses to infections -- and others don't -- have been unclear.

16 Feb 2016

Wake Forest Baptist scientists prove feasibility of printing living tissue structures for surgical implantation

Using a sophisticated, custom-designed 3D printer, regenerative medicine scientists at Wake Forest Baptist Medical Center have proved that it is feasible to print living tissue structures to replace injured or diseased tissue in patients.

15 Feb 2016

Simple physics may play key role in helping the body to fight infection

Simple physics may play a larger role than previously thought in helping control key bodily processes - such as how the body fights infection.

11 Feb 2016

CHLA researchers develop novel model for studying neonatal lung disorder

Investigators at The Saban Research Institute of Children's Hospital Los Angeles have created a novel model for studying a lung disorder of newborn babies. Their study, published in PLOS ONE on February 10, describes the first model that allows investigators to consider the chronic effects of developmental lung disease.

11 Feb 2016

Researchers identify genetic mutations that lower complications associated with diabetes

The most significant complications of diabetes include diabetic retinal disease, or retinopathy, and diabetic kidney disease, or nephropathy. Both involve damaged capillaries.

11 Feb 2016

Fasudil improves memory in rats, promotes degradation of toxic tau in the eyes of fruit flies

Could a kinase inhibitor some doctors prescribe to keep blood flowing after brain surgery be used to treat neurodegeneration? New research suggests it might be worth exploring the question.

10 Feb 2016

LMU researchers identify new drug target for atherosclerosis

The enzyme Dicer processes RNA transcripts, cutting them into short segments that regulate the synthesis of specific proteins. An Ludwig-Maximilians-Universitaet in Munich team has shown that Dicer promotes the development of atherosclerosis, thus identifying a new drug target.

10 Feb 2016

Study provides new insight into complex interchange that can raise blood levels of fat in type 1 diabetes

Researchers have new insight into the complex interchange that can raise blood levels of unhealthy lipids, or fat, in type 1 diabetes, and early evidence that a drug under study to block cancer cell growth can restore healthier levels.

8 Feb 2016

African-American patients with connective tissue diseases at risk for cardiovascular disease

A study based on medical records from more than a quarter million adult patients found that African-American patients with connective tissue diseases such as lupus or rheumatoid arthritis were twice as likely as white patients to suffer from narrowed or atherosclerotic blood vessels, which increase the risk of a heart attack, stroke or death.

5 Feb 2016

Small minority of cancer cells contribute to growth and metastasis of tumours

New research shows that a small minority of cancer cells in neuroendocrine tumours of the pancreas contribute to the overall growth and metastasis of the tumour. This discovery was made by a research group at Lund University, in collaboration with researchers at Karolinska Institutet, in Sweden.

3 Feb 2016

Combined MRI and ultramicroscopy toolkit could help study vessel growth in glioma models in more detail

Stopping the growth of blood vessels in tumours is a key target for glioblastoma therapies, and imaging methods are essential for initial diagnosis and monitoring the effects of treatments. While mapping vessels in tumours has proven a challenge, researchers have now developed a combined magnetic resonance imaging (MRI) and ultramicroscopy 'toolkit' to study vessel growth in glioma models in more detail than previously possible.

3 Feb 2016

Researchers identify definitive genetic defect in angiocentric gliomas

Diagnosis and treatment decisions for a recently recognized type of children's brain tumor should be improved by the discovery of the genetic mechanism that causes it, say researchers who identified the unusual DNA abnormality in angiocentric gliomas.

2 Feb 2016

Researchers develop new sensor for continuous monitoring of blood flow in vascular diseases patients

Frequent measurement of blood flow changes could improve the ability of health care providers to diagnose and treat patients with vascular conditions, such as those associated with diabetes and high blood pressure.

30 Jan 2016

New blood clotting analysis system could help determine effects antithrombotic (anti-clotting) drugs

A new blood clotting analysis system designed in Japan makes it easier to determine the effects of taking one or more antithrombotic (anti-clotting) drugs.

29 Jan 2016

Halaven (eribulin mesylate) approved for treatment of liposarcoma

The U.S. Food and Drug Administration today approved Halaven (eribulin mesylate), a type of chemotherapy, for the treatment of liposarcoma (a specific type of soft tissue sarcoma) that cannot be removed by surgery (unresectable) or is advanced (metastatic). This treatment is approved for patients who received prior chemotherapy that contained an anthracycline drug.

28 Jan 2016

New technique may reduce need for amputation in patients with critical limb ischemia

A new imaging technique could reduce the need for amputation in patients with critical limb ischemia, according to a study publised today in the scientific journal JACC.

28 Jan 2016

Blood Vessels News and Research

Wistar researchers find potential way for using STAT3 inhibitors to stop cancer progression

Better understanding link between oral bacteria and certain types of stroke

Vascular surgery safer than stenting for older patients with carotid stenosis

Researchers identify how Toxoplasma parasite crosses blood-brain barrier

Variations in Tie2 gene play significant role in patient responses to infections

Wake Forest Baptist scientists prove feasibility of printing living tissue structures for surgical implantation

Simple physics may play key role in helping the body to fight infection

CHLA researchers develop novel model for studying neonatal lung disorder

Researchers identify genetic mutations that lower complications associated with diabetes

Fasudil improves memory in rats, promotes degradation of toxic tau in the eyes of fruit flies

LMU researchers identify new drug target for atherosclerosis

Study provides new insight into complex interchange that can raise blood levels of fat in type 1 diabetes

African-American patients with connective tissue diseases at risk for cardiovascular disease

Small minority of cancer cells contribute to growth and metastasis of tumours

Combined MRI and ultramicroscopy toolkit could help study vessel growth in glioma models in more detail

Researchers identify definitive genetic defect in angiocentric gliomas

Researchers develop new sensor for continuous monitoring of blood flow in vascular diseases patients

New blood clotting analysis system could help determine effects antithrombotic (anti-clotting) drugs

Halaven (eribulin mesylate) approved for treatment of liposarcoma

New technique may reduce need for amputation in patients with critical limb ischemia

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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