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Animal models of Huntington's disease allow better insights into disease's genetics

Scientific progress in Huntington's disease (HD) relies upon the availability of appropriate animal models that enable insights into the disease's genetics and/or pathophysiology.

23 Apr 2013

TSRI scientists find way to directly turn bone marrow stem cells into brain cells

In a serendipitous discovery, scientists at The Scripps Research Institute have found a way to turn bone marrow stem cells directly into brain cells.

23 Apr 2013

ViroPharma announces results of VP20621 Phase 2 study for preventing recurrent CDI

ViroPharma Incorporated, an international biopharmaceutical company committed to developing and commercializing innovative products that address unmet medical needs and rare diseases, today announced the results of a Phase 2 study of VP20621 (non-toxigenic Clostridium difficile; NTCD) a novel treatment approach for preventing recurrent C. difficile infections.

23 Apr 2013

Clinical Research Forum selects sickle cell project among 'Top 10' clinical research achievements of 2012

Pioneering research led by Johns Hopkins scientists on the use of partially matched bone marrow transplants to wipe out sickle cell disease has been selected as one of the Top 10 Clinical Research Achievements of 2012 by the Clinical Research Forum.

22 Apr 2013

Study: Stem cell transplant heals neurological deficits in mice

For the first time, human embryonic stem cells have been transformed into nerve cells that helped mice regain the ability to learn and remember.

22 Apr 2013

Researchers use contrast-computed tomography for anatomical reconstruction of human heart

On April 18th JoVE (Journal of Visualized Experiments) will publish a new video article by Dr. Paul A Iaizzo demonstrating the anatomical reconstruction of an active human heart. The research uses contrast-computed tomography (CT) to allow in-depth 3-D computer modeling of hearts that can be used for prolonged archiving.

22 Apr 2013

Genetic study defines link between primary sclerosing cholangitis and other autoimmune diseases

Researchers have newly associated nine genetic regions with a rare autoimmune disease of the liver known as primary sclerosing cholangitis (PSC). This brings the total number of genetic regions associated with the disease to 16.

22 Apr 2013

Research findings describe specific profile of patients with ACLF

In this prospective study, led by Dr Richard Moreau, INSERM Research Director (Mixed Research Unit 773 "Centre de Recherche biom-dicale Bichat-Beaujon"; INSERM/Universit- Paris Diderot) who is also a practitioner attached to the Hepatology Department of the Beaujon Hospital (AP-HP), researchers studied a cohort of 1343 patients from 12 European countries.

20 Apr 2013

Arthritis drug reduces dry eye disease

Dry eye disease (DED) is a common condition that causes discomfort, visual disturbance and potentially damaging ocular surface inflammation that greatly impacts a person's quality of life.

19 Apr 2013

Research shows respiratory syncytial virus can be transferred during pregnancy to unborn baby

The most common cause of lower respiratory tract infections in infants and young children, respiratory syncytial virus (RSV), can be transferred during pregnancy to an unborn baby, according to Cleveland Clinic Children's Hospital research published online this week in the journal PLOS ONE.

19 Apr 2013

Good news: Public support increasing for living, deceased organ donation

Good news for anyone needing a transplant; a new Mayo Clinic survey shows that the public's support for both living and deceased organ donation is increasing.

19 Apr 2013

SCCA pioneers new transplant procedures to reduce need for matching bone marrow donors

Patients from ethnic minority and mixed-racial backgrounds are less likely to receive a lifesaving bone marrow transplant than Caucasian patients with the same disease due to lack of matching donors, according to the National Marrow Donor Program.

19 Apr 2013

Longer looks: The timely trauma response in Boston; Problems with aging doctors; Transplants from donors with HIV

The bombs at the Boston Marathon were designed to maim and kill, and they did. Three people died within the first moments of the blast. More than a hundred and seventy people were injured. They had their limbs blown off, vital arteries severed, bones fractured, flesh torn open by shrapnel or scorched by the blasts' heat. Yet it now appears that every one of the wounded alive when rescuers reached them will survive.

19 Apr 2013

Study shows TOLLIP gene variant is linked to increased mortality risk in IPF patients

A new study looking at the genomes of more than 1,500 patients with idiopathic pulmonary fibrosis, a rare and devastating lung disease, found multiple genetic associations with the disease, including one gene variant that was linked to an increase in the risk of death.

17 Apr 2013

Researchers report progress on non-invasive method to assess kidney function

Researchers may have found a way to block kidney-destroying inflammation and help damaged kidney cells recover.

17 Apr 2013

Viewpoints: Editorial boards offer advice to Supreme Court on gene patents

On Monday, the Supreme Court is scheduled to hear argument about that decision in Association for Molecular Pathology v. Myriad Genetics.

16 Apr 2013

Bioengineered kidneys transplanted into living rats produce urine

Bioengineered rat kidneys developed by Massachusetts General Hospital investigators successfully produced urine both in a laboratory apparatus and after being transplanted into living animals.

16 Apr 2013

Drug-eluting stents can keep clogged leg arteries open and prevent leg amputation

Drug-eluting stents can keep clogged leg arteries open, preventing amputation of the leg, suggests research being presented at the Society of Interventional Radiology's 38th Annual Scientific Meeting in New Orleans.

15 Apr 2013

Study finds racial differences in end-of-life care for patients receiving chronic dialysis

At the end of life, black patients with kidney failure receiving chronic dialysis are less likely to be referred to hospice and to discontinue dialysis compared with white patients, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology.

12 Apr 2013

Protein EPAC2 plays major role in development of type 2 diabetes

A team of researchers at the Johns Hopkins Children's Center has found that a protein long believed to have a minor role in type 2 diabetes is, in fact, a central player in the development of the condition that affects nearly 26 million people in the United States alone and counts as one of the leading causes of heart disease, stroke and kidney, eye and nerve damage.

12 Apr 2013

Transplant News and Research

Animal models of Huntington's disease allow better insights into disease's genetics

TSRI scientists find way to directly turn bone marrow stem cells into brain cells

ViroPharma announces results of VP20621 Phase 2 study for preventing recurrent CDI

Clinical Research Forum selects sickle cell project among 'Top 10' clinical research achievements of 2012

Study: Stem cell transplant heals neurological deficits in mice

Researchers use contrast-computed tomography for anatomical reconstruction of human heart

Genetic study defines link between primary sclerosing cholangitis and other autoimmune diseases

Research findings describe specific profile of patients with ACLF

Arthritis drug reduces dry eye disease

Research shows respiratory syncytial virus can be transferred during pregnancy to unborn baby

Good news: Public support increasing for living, deceased organ donation

SCCA pioneers new transplant procedures to reduce need for matching bone marrow donors

Longer looks: The timely trauma response in Boston; Problems with aging doctors; Transplants from donors with HIV

Study shows TOLLIP gene variant is linked to increased mortality risk in IPF patients

Researchers report progress on non-invasive method to assess kidney function

Viewpoints: Editorial boards offer advice to Supreme Court on gene patents

Bioengineered kidneys transplanted into living rats produce urine

Drug-eluting stents can keep clogged leg arteries open and prevent leg amputation

Study finds racial differences in end-of-life care for patients receiving chronic dialysis

Protein EPAC2 plays major role in development of type 2 diabetes

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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