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Researchers overcome obstacle to using viruses to deliver therapeutic genes

Scientists in The Research Institute at Nationwide Children's Hospital have found a way to overcome one of the biggest obstacles to using viruses to deliver therapeutic genes: how to keep the immune system from neutralizing the virus before it can deliver its genetic payload. In a study published recently in Molecular Therapy, researchers found that giving subjects a treatment to temporarily rid the body of antibodies provides the virus safe passage to targeted cells, allowing it to release a corrective or replacement gene to treat disease.

30 Oct 2013

Promising melanoma drug demonstrates potential for non-small cell lung cancer treatment

An experimental new cancer drug called MK-3475, which has shown dramatic promise for treating melanoma is also showing early potential as an effective treatment for patients with non-small cell lung cancer, the leading cause of cancer death of men and women worldwide.

30 Oct 2013

Research provides better understanding of molecular interactions related to cystic fibrosis

Research in the College of Veterinary Medicine at Kansas State University is leading to a better understanding of the molecular interactions in the thyroid gland related to cystic fibrosis.

30 Oct 2013

Janssen submits Marketing Authorization Application for Ibrutinib

Janssen-Cilag International NV (Janssen) announced today it has submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) for ibrutinib for the treatment of adult patients with relapsed or refractory chronic lymphocytic leukemia (CLL)/small lymphocytic leukemia (SLL) or relapsed or refractory mantle cell lymphoma (MCL), two forms of blood cancer.

30 Oct 2013

Wiley expands partnership with EMBO

John Wiley & Sons, Inc., today announced that it will provide editorial production, global marketing and distribution services for The EMBO Journal, EMBO reports and Molecular Systems Biology. This expanded partnership with EMBO adds three leading scientific journals alongside EMBO Molecular Medicine, which Wiley has published since 2009.

30 Oct 2013

Video gaming increases spatial orientation, memory formation and motor skills

Video gaming causes increases in the brain regions responsible for spatial orientation, memory formation and strategic planning as well as fine motor skills.

30 Oct 2013

REDDSTAR plenary meeting to be held in Berlin on Nov 5 and 6

'Diabetes- can stem cells help?' is a free, public event that will be held on Monday, 4 November 2013 from 19:00- 20:30 at The Ruin located within the Berlin Museum of Medical History, Charité. Diabetes and stem cell researchers from around Europe will assemble for a REDDSTAR plenary meeting hosted by Charité in Berlin on November 5 and 6th.

30 Oct 2013

New research reveals genetic link that connects family members with autism

Lorenzo Miodus-Santini an 11-year-old sixth-grader from Princeton, who was classified as autistic at only 13 months old, was never a big talker. As an infant he didn't babble or coo. When he was a toddler beginning to speak, he would learn one word but forget another.

30 Oct 2013

Fat recycling system may provide target for future diabetes therapies

The pancreas is a large organ that wraps around our gut, and produces the exact amount of insulin our bodies need when we eat - except when we start to develop diabetes, and insulin production slows down. Sydney scientists describe how a fat recycling system within pancreatic 'beta cells' determines the amount of insulin they secrete, and so may provide a target for future diabetes therapies.

30 Oct 2013

Physician treatment perceptions in actinic keratosis: an interview with Kim Kjøller, Senior Vice President for Global Development, LEO Pharma

Firstly, actinic keratosis (AK) is a common dermatological condition caused by cumulative exposure to the sun. Providing patients with effective treatment is very important, as AK can lead to forms of non-melanoma skin cancer (NMSC) if not diagnosed and treated early. In fact, two in three cases of squamous cell carcinoma (a common form of skin cancer), begin as AK.

29 Oct 2013

3Sbio acquires patents for DJ5 to delay hereditary renal disease in ADPKD patients

3SBio Inc., a leading China-based biotechnology company focused on researching, developing, manufacturing and marketing biopharmaceutical products, announced the acquisition of patents for DJ5, a novel non-TZD PPARgamma agonist with potential to retard progressive renal failure in patients with autosomal dominant polycystic kidney disease ("ADPKD').

29 Oct 2013

Study: Glucose levels, vascular damage contribute to dementia

High blood-sugar levels, such as those linked with Type 2 diabetes, make beta amyloid protein associated with Alzheimer's disease dramatically more toxic to cells lining blood vessels in the brain, according to a new Tulane University study published in latest issue of the Journal of Alzheimer's Disease.

29 Oct 2013

Cytrx announces Q3 2013 financial results, provides clinical update

CytRx Corporation, a biopharmaceutical research and development company specializing in oncology, today reported financial results for the three and nine-month periods ended September 30, 2013, and provided a clinical update.

29 Oct 2013

Pharmalink's Busulipo receives FDA orphan drug designation

Pharmalink AB, a specialty pharma company focused on orphan and niche products, today announces its product Busulipo, a best-in-class conditioning agent for use in cancer patients prior to hematopoietic stem cell transplantation (HSCT; also known as bone marrow transplantation), has received orphan drug designation from the US Food and Drug Administration.

29 Oct 2013

New unique nanostructure to target drug-delivery treatment of cancer cells

A unique nanostructure developed by a team of international researchers, including those at the University of Cincinnati, promises improved all-in-one detection, diagnoses and drug-delivery treatment of cancer cells.

29 Oct 2013

Lipid secreted by tumors inhibits immune response against cancer

Researchers at National Jewish Health have discovered how a lipid secreted by cancer tumors prevents the immune system from mounting an immune response against it. When lysophosphatidic acid binds to killer T cells, it acts almost like an "invisibility cloak," preventing T cells from recognizing and attacking nascent tumors.

29 Oct 2013

Study shows how wrong levels of protein linked with AD can lead to dangerous blockages in brain cells

Scientists have known for some time that a protein called presenilin plays a role in Alzheimer's disease, and a new study reveals one intriguing way this happens.

29 Oct 2013

Research findings open up possibility for developing potent anti-clotting drugs

Researchers at the University of Illinois at Chicago have discovered a molecular switch that causes small, beneficial clots that stop bleeding to enlarge further during wound healing. By blocking this switch in lab mice, the researchers prevented small clots from growing -- a process that can pose a danger in humans -- while preserving their ability to staunch bleeding

29 Oct 2013

Infants who get hepatitis C from mothers during childbirth may inherit viral strain

Infants who get hepatitis C from their mothers during childbirth may inherit a viral strain that replicates more quickly than strains found in non-pregnant hosts, according to a new study published Oct. 27 in Nature Medicine.

29 Oct 2013

Study: Light enhances brain activity during cognitive task even in blind people

Light enhances brain activity during a cognitive task even in some people who are totally blind, according to a study conducted by researchers at the University of Montreal and Boston's Brigham and Women's Hospital.

29 Oct 2013