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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

IRB Barcelona researchers find the Achilles heel of some lung tumors

In cancer, personalized medicine takes advantage of the unique genetic changes in an individual tumor to find its vulnerabilities and fight it.

8 Apr 2021

Microrna-29 molecule controls brain maturation in mammals

A team led by scientists at the UNC School of Medicine identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29 in mice caused problems very similar to those seen in autism, epilepsy, and other neurodevelopmental conditions.

8 Apr 2021

Study: H2AK119ub1 is necessary for maternal inheritance of H3K27me3

An epigenetic study at the RIKEN Center for Integrative Medical Sciences shows that in mouse egg cells, modifications to histone H2A at lysine 119 lay the groundwork for inherited DNA functional modifications from the mother.

8 Apr 2021

PNA-based gene editing technique can advance gene discovery

In an article published in the April 8 issue of Nature, the National Institutes of Health's Somatic Cell Gene Editing Consortium provided a detailed update on the progress of their nationwide effort to develop safer and more effective methods to edit the genomes of disease-relevant somatic cells and reduce the burden of disease caused by genetic changes.

8 Apr 2021

Racial diversity and poverty may influence heart-failure morbidity and mortality

Race associates with the risk of death from end-stage heart failure. So, identifying the molecular determinants of that risk may help the pursuit of the novel diagnosis and prognosis of heart failure, and its therapy.

8 Apr 2021

Researchers characterize genetic intra-tumor heterogeneity across cancer genomes

Researchers at the Francis Crick Institute, as part of an international collaboration of scientists through the Pan-Cancer Analysis of Whole Genomes Consortium, have analyzed the whole genomes of tumor samples from over 2,600 patients with different types of cancer.

7 Apr 2021

Advancing the Diagnosis and Treatment of Ovarian Cancer

In this interview, News-Medical talks to Dr. Marcos Quintela Vasquez about the work he is conducting regarding the diagnosis and treatment of ovarian cancer in partnership with Porvair Sciences.

From Porvair Sciences Limited 7 Apr 2021

Gut microbiome communicates with horse’s cells to enhance their athletic performance

A horse’s gut microbiome communicates with its host by sending chemical signals to its cells, which has the effect of helping the horse to extend its energy output, finds a new study published in Frontiers in Molecular Biosciences.

7 Apr 2021

Individuals with Major Depressive Disorder have accelerated cellular aging

Cells from individuals with Major Depressive Disorder (MDD) were found to have higher than expected rates of methylation at specific sites on their DNA, when compared to cells from healthy individuals without MDD, according to a study by a multidisciplinary team of UC San Francisco scientists, in collaboration with others.

7 Apr 2021

New grant to Harvard Medical School is boosting efforts to understand and combat rare cancers

Curing cancer has been the dream of countless doctors and researchers over the decades. Yet some types of cancer, whether because they affect relatively few people or lack influential advocates, receive less attention and funding than others.

7 Apr 2021

UNC scientists identify a molecule as powerful controller of brain maturation in mammals

7 Apr 2021

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre have discovered how certain proteins ensure the repair of errors introduced into the DNA during its replication.

6 Apr 2021

Researchers explore link between intestinal microbiota with colon cancer in patients with Lynch Syndrome

The researcher Gabriela Debesa, member of the research group at Simbiosis led by Andrés Moya at the Foundation for the Promotion of Health and Biomedical Research of Valencia Region (Fisabio), studied the relationship of the intestinal microbiota with colon cancer in patients with Lynch Syndrome (a hereditary illness that predisposes the development of cancer) using tissue samples in formalin and conserved in paraffin.

6 Apr 2021

Researchers define genetic landscape of uterine leiomyosarcomas

In a new study, Yale Cancer Center researchers have defined the genetic landscape of uterine leiomyosarcomas (uLMS).

6 Apr 2021

Oncogenic RAS mutations are responsible for regrowth of cancer cells following genotoxic therapies

In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options.

6 Apr 2021

New RNA-sequencing method can help detect numerous modified small RNAs

A team led by a biomedical scientist at the University of California, Riverside, has developed a new RNA-sequencing method-- "Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing," or PANDORA-seq -- that can help discover numerous modified small RNAs that were previously undetectable.

5 Apr 2021

Discovering DNA methylation from bacteria and microbiome using nanopore technology

Bacterial DNA methylation occurs at diverse sequence contexts and plays important functional roles in cellular defense and gene regulation. An increasing number of studies have reported that bacterial DNA methylation has important roles affecting clinically relevant phenotypes such as virulence, host colonization, sporulation, biofilm formation, among others.

5 Apr 2021

DNA News and Research

Further Reading

IRB Barcelona researchers find the Achilles heel of some lung tumors

Microrna-29 molecule controls brain maturation in mammals

Study: H2AK119ub1 is necessary for maternal inheritance of H3K27me3

PNA-based gene editing technique can advance gene discovery

Racial diversity and poverty may influence heart-failure morbidity and mortality

Researchers characterize genetic intra-tumor heterogeneity across cancer genomes

Advancing the Diagnosis and Treatment of Ovarian Cancer

Gut microbiome communicates with horse’s cells to enhance their athletic performance

Individuals with Major Depressive Disorder have accelerated cellular aging

New grant to Harvard Medical School is boosting efforts to understand and combat rare cancers

UNC scientists identify a molecule as powerful controller of brain maturation in mammals

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Researchers explore link between intestinal microbiota with colon cancer in patients with Lynch Syndrome

Researchers define genetic landscape of uterine leiomyosarcomas

Oncogenic RAS mutations are responsible for regrowth of cancer cells following genotoxic therapies

New RNA-sequencing method can help detect numerous modified small RNAs

Discovering DNA methylation from bacteria and microbiome using nanopore technology

Researchers study how social media misinformation influences vaccine readiness in Appalachia

First-of-its-kind study identifies 13 new Alzheimer’s disease genes

Targeting microRNAs makes cancer stem cells more susceptible to chemotherapies

eBook: Exploring the Cell Cycle and DNA Damage and Repair eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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