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New approach could help identify specific gene mutations linked to increased disease risk

Researchers at the University of California, San Diego School of Medicine have developed a new way to parse and understand how special proteins called "master regulators" read the genome, and consequently turn genes on and off.

13 Oct 2013

NIH selects Salk scientist for EUREKA grant

The National Institutes of Health has selected Axel Nimmerjahn for a highly competitive EUREKA (Exceptional Unconventional Research Enabling Knowledge Acceleration) grant. Dr. Nimmerjahn is an Assistant Professor in the Waitt Advanced Biophotonics Center and holds the Richard Allan Barry Developmental Chair.

13 Oct 2013

UCLA, Takeda to study how disruption of circadian rhythms promotes type 2 diabetes

Millions of individuals worldwide are exposed to shift work and numerous environmental conditions that disturb circadian clock function and disrupt normal circadian rhythms. Environmental conditions associated with disrupted circadian rhythms greatly increase the risk for development of type 2 diabetes and metabolic syndrome and also hinder the treatment and management of hyperglycemia in existing patients with diabetes.

13 Oct 2013

Deficiency of antioxidant response protein prevents hypertrophic cardiomyopathy

University of Utah researchers have found that deficiency of an antioxidant response protein called nuclear erythroid-2 like factor-2 (Nrf2) delays or prevents hypertrophic cardiomyopathy, a type of a heart failure in which the heart muscle grows abnormally thick.

12 Oct 2013

Research findings may lead to new ways to combat cancer

The way cells divide to form new cells - to support growth, to repair damaged tissues, or simply to maintain our healthy adult functioning - is controlled in previously unsuspected ways UC San Francisco researchers have discovered.

12 Oct 2013

Researchers discover how Fra-1 protein protects the liver from drug-induced liver damage

Drug abuse and alcohol are some of the most frequent causes of liver damage, particularly in developed countries. Such kind of liver damage can cause irreversible liver failure and even cancer. Researchers from the Spanish National Cancer Research Centre have discovered an important new protective role of the Fra-1 protein, which neutralizes the damage caused by agents, such as the analgesic drug acetaminophen (Paracetamol).

12 Oct 2013

Research findings may lead to potential treatments for inherited diseases

New research from the University of California, Davis, shows that the tiny proportion of a cell's DNA that is located outside the cell nucleus has a disproportionately large effect on a cell's metabolism.

12 Oct 2013

People who lower stress levels through meditation, yoga have longer telomeres

Targeting telomeres, the protective caps at the end of all chromosomes that are critical to healthy cell function, T.A. Sciences' products activate an enzyme that can slow down and possibly reverse age- and lifestyle-related telomere shortening. Short telomeres can cause mutations and degradations to chromosomes leading to loss of cell functionality. Its inaugural product, TA-65 is the only proven product specifically focused on the telomerase activation market.

12 Oct 2013

Novartis Inks Agreement For Immunogen's "TAP" ADC Technology

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11 Oct 2013

Novartis Inks Agreement For Immunogen's "TAP" ADC Technology

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11 Oct 2013

High voltage, short pulsed electric fields destroy cells in skin tissue, lead to scarless tissue regeneration

High voltage, short pulsed electric fields, used for disinfection and solid tumor destruction, selectively damage cell membranes, while preserving overall tissue structure, a phenomenon that may be a key factor in scarless tissue regeneration.

11 Oct 2013

ImmunoGen signs new license agreement with Novartis

ImmunoGen, Inc., a biotechnology company that develops novel anticancer therapeutics using its antibody-drug conjugate technology, today announced that Novartis has licensed the exclusive right to use the Company's ADC technology to develop anticancer therapeutics to an undisclosed target.

11 Oct 2013

New gene transfer strategy effective for achieving persistent immunotherapy to treat tumors

Cancer immunotherapy can successfully use the body's own immune system to kill tumor cells. But some current approaches to stimulate an antitumor immune response are short-lived, with limited clinical effectiveness. A new gene transfer strategy that introduces modified, immune-stimulating human stem cells is both feasible and effective for achieving persistent immunotherapy to treat leukemias and lymophomas, according to a study published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

11 Oct 2013

HSCI researchers discover on-off switch for gene expression

Harvard Stem Cell Institute researchers have settled a century-old debate over whether occurrence of DNA methylation acts to silence gene expression, or if genes are turned off by other means before they are methylated.

11 Oct 2013

Super-enhancers could play important roles in disease diagnostics and therapeutics

Having recently discovered a set of powerful gene regulators that control cell identity in a few mouse and human cell types, Whitehead Institute scientists are now showing that these regulators-which they named "super-enhancers"-act across a vast array of human cell types and are enriched in mutated regions of the genome that are closely associated with a broad spectrum of diseases.

11 Oct 2013

Scientists develop new method to create stem cells for human liver and pancreas

A new method for creating stem cells for the human liver and pancreas, which could enable both cell types to be grown in sufficient quantities for clinical use, has been developed by scientists.

11 Oct 2013

TSRI scientists discover viable strategy for weight loss in people

Scientists at The Scripps Research Institute have discovered key details of a brain-to-body signaling circuit that enables roundworms to lose weight independently of food intake. The weight-loss circuit is activated by combined signals from the worm versions of the neurotransmitters serotonin and adrenaline, and there are reasons to suspect that it exists in a similar form in humans and other mammals.

11 Oct 2013

Scientists to combine NK cell therapy with immunocytokine to target childhood cancer

Researchers have made rapid advances in understanding how to manipulate the immune system safely to destroy cancer cells. Adoptive transfer of haploidentical natural killer cells has shown promise as a treatment option to target and kill cancer cells in a less toxic way than conventional therapies. Now for the first time, scientists will combine NK cell therapy with an immunocytokine to target children with relapsed/refractory disease including those with bulky tumors.

11 Oct 2013

Genetic mutation that protects skin from UV radiation may cause testicular cancer in Caucasian

A Ludwig Cancer Research study published in Cell today identifies a common mutation that dramatically increases the risk for testicular cancer—and describes a likely molecular mechanism by which it exerts that effect.

11 Oct 2013

Osiris Therapeutics agrees to sell ceMSC business to Mesoblast

Osiris Therapeutics, Inc. announced today that it has entered into an agreement with a wholly-owned subsidiary of Mesoblast Limited for the sale of Osiris' culture-expanded mesenchymal stem cell business, including Prochymal, in a transaction worth up to $100 million in initial consideration and milestone payments.

11 Oct 2013

Cell News and Research

New approach could help identify specific gene mutations linked to increased disease risk

NIH selects Salk scientist for EUREKA grant

UCLA, Takeda to study how disruption of circadian rhythms promotes type 2 diabetes

Deficiency of antioxidant response protein prevents hypertrophic cardiomyopathy

Research findings may lead to new ways to combat cancer

Researchers discover how Fra-1 protein protects the liver from drug-induced liver damage

Research findings may lead to potential treatments for inherited diseases

People who lower stress levels through meditation, yoga have longer telomeres

Novartis Inks Agreement For Immunogen's "TAP" ADC Technology

Novartis Inks Agreement For Immunogen's "TAP" ADC Technology

High voltage, short pulsed electric fields destroy cells in skin tissue, lead to scarless tissue regeneration

ImmunoGen signs new license agreement with Novartis

New gene transfer strategy effective for achieving persistent immunotherapy to treat tumors

HSCI researchers discover on-off switch for gene expression

Super-enhancers could play important roles in disease diagnostics and therapeutics

Scientists develop new method to create stem cells for human liver and pancreas

TSRI scientists discover viable strategy for weight loss in people

Scientists to combine NK cell therapy with immunocytokine to target childhood cancer

Genetic mutation that protects skin from UV radiation may cause testicular cancer in Caucasian

Osiris Therapeutics agrees to sell ceMSC business to Mesoblast

How to optimize your cell line development eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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