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FDA accepts, files Genentech's sBLA for subcutaneous use of Xolair in people with CIU

Genentech, a member of the Roche Group, today announced that the U.S. Food and Drug Administration has accepted and filed the company's supplemental Biologics License Application for subcutaneous use of Xolair (omalizumab) in people with Chronic Idiopathic Urticaria who remained symptomatic despite treatment with H1-antihistamine therapy at approved doses.

11 Oct 2013

Specialized cells in the stomach more often revert to stem cells

New research has shown that the stomach naturally produces more stem cells than previously realized, likely for repair of injuries from infections, digestive fluids and the foods we eat.

11 Oct 2013

Researchers find ways to identify, isolate HCC progenitor cells before tumors become evident

For the first time, researchers at the University of California, San Diego School of Medicine have isolated and characterized the progenitor cells that eventually give rise to malignant hepatocellular carcinoma tumors - the most common form of liver cancer. The researchers found ways to identify and isolate the HCC progenitor cells long before actual tumors were apparent.

11 Oct 2013

Researchers identify gene that orchestrates important branching of nerve fibers

Our ability to detect heat, touch, tickling and other sensations depends on our sensory nerves. Now, for the first time, researchers at Albert Einstein College of Medicine of Yeshiva University have identified a gene that orchestrates the crucially important branching of nerve fibers that occurs during development. The findings were published online today in the journal Cell.

11 Oct 2013

Suppression of mitochondria: A dominant feature of diabetic kidney disease

Researchers at the University of California, San Diego School of Medicine have identified 13 metabolites - small molecules produced by cellular metabolism - that are significantly different in patients with diabetes and chronic kidney disease compared to healthy controls.

11 Oct 2013

Small interfering RNAs in mammals act as specific antiviral weapons

Many viral infections are nipped in the bud by the innate immune response. This involves specific proteins within the infected cell that recognize the virus and trigger a signalling cascade - the so-called interferon response. This activates a protective mechanism in neighbouring cells and often results in the death of the primarily infected cell.

11 Oct 2013

Finding highlights new ways of treating inflammation disorders

A team led by scientists at The Scripps Research Institute (TSRI) has identified key signaling proteins in the inflammation process that contribute to the development of inflammatory diseases such as rheumatoid arthritis, psoriasis, sepsis and inflammatory bowel diseases.

11 Oct 2013

Research delves deeply into genomics of glioblastoma multiforme cases to better target disease

When The Cancer Genome Atlas launched its massively collaborative approach to organ-by-organ genomic analysis of cancers, the brain had both the benefit, and the challenge, of going first.

11 Oct 2013

Researchers discover how the body's muscles accidentally fall asleep while awake

Normally muscles contract in order to support the body, but in a rare condition known as cataplexy the body's muscles "fall asleep" and become involuntarily paralyzed. Cataplexy is incapacitating because it leaves the affected individual awake, but either fully or partially paralyzed. It is one of the bizarre symptoms of the sleep disorder called narcolepsy.

11 Oct 2013

Palliative chemoradiation boosts survival, QoL in poor-prognosis NSCLC

C hemoradiation is superior to chemotherapy alone with respect to both survival and quality of life in patients with inoperable non-small-cell lung cancer, a phase III trial has found.

10 Oct 2013

Diverse Neurological Disorders Appear To Share Tangled Metabolic Roots

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10 Oct 2013

Vivaldi Buys Flu Vaccine R&D Assets From Baxter

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10 Oct 2013

Combining gene therapy with stem cells leads to faster healing of burns

Johns Hopkins researchers, working with elderly mice, have determined that combining gene therapy with an extra boost of the same stem cells the body already uses to repair itself leads to faster healing of burns and greater blood flow to the site of the wound.

10 Oct 2013

Heptares' StaR platform offers breakthrough solution to challenge associated with antibodies therapeutics

Heptares Therapeutics, the leading GPCR structure-guided drug discovery and development company, achieved the first research milestone in its antibody therapeutics alliance with MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX), announced in February 2013.

10 Oct 2013

Charles J. Sherr to receive Prize for Scientific Excellence in Medicine

Charles J. Sherr, M.D., Ph.D., chair of the St. Jude Children's Research Hospital Department of Tumor Cell Biology and a Howard Hughes Medical Institute Investigator, has been selected to receive the 2013 Prize for Scientific Excellence in Medicine by the American-Italian Cancer Foundation.

10 Oct 2013

Auckland physician performs first patient implant of Boston Scientific Innova DES System

Launching a key clinical trial expected to serve as the foundation for global regulatory approvals, a physician in Auckland, New Zealand has performed the first patient implant of the Boston Scientific Corporation Innova Drug-Eluting Stent System.

10 Oct 2013

Phase 3 study of idelalisibin reports positive results in CLL patients

Following a recommendation by an independent Data Monitoring Committee (DMC), Gilead Sciences, Inc. (Nasdaq:GILD) today announced that its Phase 3 study (Study 116) evaluating idelalisib in previously-treated chronic lymphocytic leukemia (CLL) patients who are not fit for chemotherapy will be stopped early.

10 Oct 2013

Pfizer reports positive results from two tofacitinib Phase 3 trials for chronic plaque psoriasis

Pfizer Inc. announced today top-line results from two Phase 3 clinical trials of tofacitinib, a novel, oral Janus kinase inhibitor that is being investigated for the treatment of adults with moderate-to-severe chronic plaque psoriasis: OPT Compare (A3921080) and OPT Retreatment (A3921111).

10 Oct 2013

Gene mutation offers clues to development of diverse neurological disorders

A research team, headed by Theodore Friedmann, MD, professor of pediatrics at the University of California, San Diego School of Medicine, says a gene mutation that causes a rare but devastating neurological disorder known as Lesch-Nyhan syndrome appears to offer clues to the developmental and neuronal defects found in other, diverse neurological disorders like Alzheimer's, Parkinson's and Huntington's diseases.

10 Oct 2013

Researcher receives grant to explore HER2-positive breast tumor susceptibility to PARP inhibitors

Shih-Hsin (Eddy) Yang, M.D., Ph.D., the ROAR Southeast Cancer Foundation Endowed Chair in the University of Alabama at Birmingham Department of Radiation Oncology, has received a $450,000 grant from Susan G. Komen for the Cure to further investigate HER2-positive breast tumor susceptibility to PARP inhibitors.

10 Oct 2013

Cell News and Research

FDA accepts, files Genentech's sBLA for subcutaneous use of Xolair in people with CIU

Specialized cells in the stomach more often revert to stem cells

Researchers find ways to identify, isolate HCC progenitor cells before tumors become evident

Researchers identify gene that orchestrates important branching of nerve fibers

Suppression of mitochondria: A dominant feature of diabetic kidney disease

Small interfering RNAs in mammals act as specific antiviral weapons

Finding highlights new ways of treating inflammation disorders

Research delves deeply into genomics of glioblastoma multiforme cases to better target disease

Researchers discover how the body's muscles accidentally fall asleep while awake

Palliative chemoradiation boosts survival, QoL in poor-prognosis NSCLC

Diverse Neurological Disorders Appear To Share Tangled Metabolic Roots

Vivaldi Buys Flu Vaccine R&D Assets From Baxter

Combining gene therapy with stem cells leads to faster healing of burns

Heptares' StaR platform offers breakthrough solution to challenge associated with antibodies therapeutics

Charles J. Sherr to receive Prize for Scientific Excellence in Medicine

Auckland physician performs first patient implant of Boston Scientific Innova DES System

Phase 3 study of idelalisibin reports positive results in CLL patients

Pfizer reports positive results from two tofacitinib Phase 3 trials for chronic plaque psoriasis

Gene mutation offers clues to development of diverse neurological disorders

Researcher receives grant to explore HER2-positive breast tumor susceptibility to PARP inhibitors

What are the challenges of cell line development? eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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