Amyotrophic Lateral Sclerosis News and Research

RSS

Alnylam reports further progress on broadening the therapeutic potential of RNAi

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today further progress on the Company's platform efforts in extrahepatic delivery of novel siRNA conjugates, including central nervous system (CNS) and ocular delivery in rat and non-human primates (NHPs).

3 Oct 2018

Olfactory cells could act as 'Trojan horse,' delivering anticancer therapy to dangerous brain tumors

A special type of cell essential to the ability of olfactory neurons to regenerate may be genetically engineered to deliver anticancer therapy to the dangerous brain tumors called glioblastomas.

27 Sep 2018

Urine exRNA may be source of biomarkers for muscular dystrophy

Massachusetts General Hospital researchers have found that extracellular RNA in urine may be a source of biomarkers for the two most common forms of muscular dystrophy, noninvasively providing information about whether therapeutic drugs are having the desired effects on a molecular level.

26 Sep 2018

Alzheimer’s disease researchers makes significant breakthroughs

Researchers in Sweden and United Kingdom have made a breakthrough in Alzheimer’s disease research. They could soon be on the path to develop new drugs that could fight the disease more effectively.

26 Sep 2018

Genervon reports new findings that drug candidate GM6 attenuates Alzheimer's disease in mice model

Following the closure of several research programs for Alzheimer's disease, in early 2018 the FDA issued a release entitled "Draft Guidance for Industry: Early Alzheimer's Disease: Developing Drugs for Treatment." Encouraged by the proposed changes in the new guidance, Genervon's research team reported new findings that its drug candidate GM6 attenuates Alzheimer's disease in an early AD transgenic APP mice model.

25 Sep 2018

Novel finding that links ALS/ataxia to cellular stress opens door to new treatment approaches

Few treatments exist for neurodegenerative diseases that progressively rob a person's ability to move and think, yet the results of a new study could potentially open additional approaches for exploration.

7 Sep 2018

Scientists discover ALS disease mechanism

A mechanism for how the disease ALS evolves has been discovered at Umeå University, Sweden. The discovery concerns how proteins with a defect structure spread the deformation to other proteins. This according to results in a new thesis.

4 Sep 2018

Study: First independent in-home use of brain-computer interface by ALS patients shows promise

Laboratory studies have shown the potential for patients with amyotrophic lateral sclerosis, who cannot move or speak, to communicate using a brain-computer interface.

30 Aug 2018

Clinical trial: Promising drug slows brain shrinkage in progressive MS patients

A promising drug slowed brain shrinkage in progressive multiple sclerosis (MS) by nearly half, according to new research led by Cleveland Clinic. Very limited therapies are currently available for this disabling form of the disease.

30 Aug 2018

Proteins that protect neurons from destruction can be delivered through nose

Protective proteins that mitigate the destruction of nerve cells after a stroke can be administered into the brain through the nose, as Heidelberg University researchers demonstrated using a mouse model.

24 Aug 2018

New project receives $3.2 million grant to investigate secrets of programmed cell death in Alzheimer's

Most neurons in the human brain live out their lives, enduring the processes of aging before eventually dying. Some, however, choose a more violent route: suicide.

24 Aug 2018

MDA announces 34 new grants totaling $9.9 million to accelerate neuromuscular research

The Muscular Dystrophy Association today announced the award of 34 new grants totaling more than $9.9 million for its summer round of funding. These new grants represent a continued commitment by MDA to fund groundbreaking research that will accelerate treatments and cures for the more than 40 diseases in its program.

24 Aug 2018

Study provides new clues to connection between aging and neurodegeneration

For decades researchers have worked to shed light on the causes of neurodegenerative disorders, a group of devastating conditions, including Alzheimer's and Parkinson's, that involve the progressive loss of neurons and nervous system function. In recent years, numerous factors, from genetic mutations to viral infections, have been found to contribute to the development of these diseases.

23 Aug 2018

Study shows that rogue proteins may underlie some ALS and frontotemporal dementia cases

ALS -- amyotrophic lateral sclerosis -- is a neurodegenerative disease that attacks motor neurons in the brain and spinal cord, slowly robbing its victims of their ability to walk, talk, breathe and swallow.

20 Aug 2018

‘No one is ever really ready’: Aid-in-dying patient chooses his last day

In the end, it wasn't easy for Aaron McQ to decide when to die. The 50-year-old Seattle man — a former world traveler, triathlete and cyclist — learned he had leukemia five years ago, followed by an even grimmer diagnosis in 2016: a rare form of amyotrophic lateral sclerosis, or ALS.

14 Aug 2018

PARP inhibitors show promise for treating and preventing brain disorders

A class of cancer drugs called PARP inhibitors could be useful for treating and preventing brain disorders, including amyotrophic lateral sclerosis, also called Lou Gehrig's disease, and some forms of frontotemporal degeneration, by halting the misplacement of specific proteins that affect nerve cells, according to a study published in Molecular Cell by researchers in the the School of Arts and Sciences and the Perelman School of Medicine at the University of Pennsylvania.

10 Aug 2018

Amyotrophic Lateral Sclerosis News and Research

Alnylam reports further progress on broadening the therapeutic potential of RNAi

Olfactory cells could act as 'Trojan horse,' delivering anticancer therapy to dangerous brain tumors

Urine exRNA may be source of biomarkers for muscular dystrophy

Alzheimer’s disease researchers makes significant breakthroughs

Genervon reports new findings that drug candidate GM6 attenuates Alzheimer's disease in mice model

Novel finding that links ALS/ataxia to cellular stress opens door to new treatment approaches

Scientists discover ALS disease mechanism

Study: First independent in-home use of brain-computer interface by ALS patients shows promise

Clinical trial: Promising drug slows brain shrinkage in progressive MS patients

Proteins that protect neurons from destruction can be delivered through nose

New project receives $3.2 million grant to investigate secrets of programmed cell death in Alzheimer's

MDA announces 34 new grants totaling $9.9 million to accelerate neuromuscular research

Study provides new clues to connection between aging and neurodegeneration

Study shows that rogue proteins may underlie some ALS and frontotemporal dementia cases

‘No one is ever really ready’: Aid-in-dying patient chooses his last day

PARP inhibitors show promise for treating and preventing brain disorders

Collaboration between Merck and InnoCore could improve biologic drug delivery

Study: HDAC1 enzyme modifies molecular motor that drives neuron death

New study uses metabolomics to compare lipid profiles of infant formulas and human milk

Newer version of ALS drug may effectively treat inherited form of the disease

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

Latest News