Interferon News and Research

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What is the association between T lymphocyte-mediated immune responses and COVID-19 severity?

Researchers examined the relationship between cell-mediated or T lymphocyte-mediated immunity and SARS-CoV-2 infection severity.

25 Aug 2022

The role of SARS-CoV-2-specific T cells induced by infection, vaccination, or their combination in disease protection

Researchers evaluated how SARS-CoV-2-specific-T lymphocytes induced by infection, vaccination, or both conferred protection against severe COVID-19.

24 Aug 2022

How could SARS-CoV-2 viral infection modulate the immune landscape during the active infection phase and recovery in pregnant females?

Researchers examined immune reflexes towards SARS-CoV-2 infection among pregnant women.

24 Aug 2022

Glucokinase activator AZD1656 shows potential benefit for diabetics with moderate to severe COVID-19

A new study examines the potential benefit of the glucokinase activator molecule AZD1656 in the ARCADIA trial.

23 Aug 2022

Clinicopathological correlations and obstetric management of pregnant women with monkeypox virus infection

Researchers described the impact, potential mechanisms, and management of maternal and fetal monkeypox virus infections.

23 Aug 2022

The role of SARS-CoV-2 in COVID-19-associated chilblains

A recent study published in the British Journal of Dermatology evaluated COVID-19-associated chilblains.

23 Aug 2022

Scientists begin phase 2 clinical trials of lupus pill

Lupus is an autoimmune disease that attacks organs and can be fatal. There's no cure, so current treatments aim to limit damage and ameliorate symptoms.

22 Aug 2022

The impact of the P681H spike mutation in the SARS-CoV-2 Alpha variant

Researchers demonstrated the relevance of the P681H spike mutation in the SARS-CoV-2 Alpha variant.

17 Aug 2022

Interferon beta reduces binding of three components to RBCs, study finds

Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce proinflammatory molecules and even increase production of anti-inflammatory species in MS patients.

11 Aug 2022

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

Stimulator of interferon genes, or STING, helps regulate immune activation. Thus, drugs that activate STING are being tested as a form of cancer immunotherapy and for treating certain infections.

11 Aug 2022

Review of natural products with promising anti-SARS-CoV-2 potential

In a new study, researchers reviewed existing literature on naturally active products with therapeutic efficacy against SARS-CoV-2.

10 Aug 2022

Study evaluates two immunization schedules for the inactivated SARS-CoV-2 vaccine Coronavac

Researchers conducted phase 3 evaluations of the immunogenicity of the two immunization timeframes of the CoronaVac COVID-19 vaccine among Chilean adults.

10 Aug 2022

B-cell responses to COVID mRNA vaccine are enhanced by a 16-week interval between doses

Researchers assess the impact of extending the interval between primary and booster COVID-19 vaccine doses.

9 Aug 2022

Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Researchers evaluated the comparative pathogenicity of SARS-CoV-2 Omicron sub-variants BA.1, BA.2, and BA.5, in vitro and in vivo.

9 Aug 2022

Researchers identify immune expression signature in surgical specimens linked to disease progression for non-CPR patients

Researchers from Spain have identified an immune expression signature in surgical specimens associated with disease progression for non-complete pathological responders patients treated with neo adjuvant chemo-immunotherapy, which could help the follow-up and therapeutic management of these high-risk patients.

8 Aug 2022

Researchers identify new therapies that could provide better protection against future COVID-19 variants

Researchers from the University of Kent in Canterbury, UK and the Goethe-University in Frankfurt am Main have identified new therapies for COVID-19 that could provide better protection against future variants and outbreaks.

8 Aug 2022

Gut microbiota-derived metabolites offer protection against SARS-CoV-2

A new study investigated how the gut microbiome confers immunity to mammalian hosts against SARS-CoV-2 intranasal infection by generating short-chain fatty acids.

5 Aug 2022

A combined influenza and COVID-19 mRNA vaccine

A combined mRNA vaccine is capable of inducing broad and durable protection against co-infection with SARS-CoV-2 and IAV,

3 Aug 2022

Hybrid immunity retained six months after SARS-CoV-2 exposure

Scientists hypothesize that lower death rates in COVID-19 patients may be due to hybrid immunity, as well as the reduced severity of Omicron infections.

3 Aug 2022

Persistent viral infections within hosts cause post-acute sequelae of COVID-19, research shows

A research team, comprised of Associate Professor Tomonari Sumi of the Research Institute for Interdisciplinary Science at Okayama University and Associate Professor Kouji Harada of the Center for IT-based Education at Toyohashi University of Technology, has developed a mathematical model of the immune response within infected hosts that considers systemic infection of a novel coronavirus (SARS-CoV-2), and demonstrated by conducting experimental computer simulations that persistent viral infections within hosts potentially cause long COVID or post-acute sequelae of COVID-19.

3 Aug 2022

Interferon News and Research

What is the association between T lymphocyte-mediated immune responses and COVID-19 severity?

The role of SARS-CoV-2-specific T cells induced by infection, vaccination, or their combination in disease protection

How could SARS-CoV-2 viral infection modulate the immune landscape during the active infection phase and recovery in pregnant females?

Glucokinase activator AZD1656 shows potential benefit for diabetics with moderate to severe COVID-19

Clinicopathological correlations and obstetric management of pregnant women with monkeypox virus infection

The role of SARS-CoV-2 in COVID-19-associated chilblains

Scientists begin phase 2 clinical trials of lupus pill

The impact of the P681H spike mutation in the SARS-CoV-2 Alpha variant

Interferon beta reduces binding of three components to RBCs, study finds

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

Review of natural products with promising anti-SARS-CoV-2 potential

Study evaluates two immunization schedules for the inactivated SARS-CoV-2 vaccine Coronavac

B-cell responses to COVID mRNA vaccine are enhanced by a 16-week interval between doses

Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Researchers identify immune expression signature in surgical specimens linked to disease progression for non-CPR patients

Researchers identify new therapies that could provide better protection against future COVID-19 variants

Gut microbiota-derived metabolites offer protection against SARS-CoV-2

A combined influenza and COVID-19 mRNA vaccine

Hybrid immunity retained six months after SARS-CoV-2 exposure

Persistent viral infections within hosts cause post-acute sequelae of COVID-19, research shows

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