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Updated results from two clinical trials of Bruton's ibrutinib for CLL/SLL

Pharmacyclics, Inc announced today at the 17th Congress of European Hematology Association updated results from two clinical trials of Bruton's tyrosine kinase (BTK) inhibitor, ibrutinib (PCI-32765), for the treatment of patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).

18 Jun 2012

Impressive results from blinatumomab Phase 2 study on B-precursor ALL

At the 17th Congress of the European Hematology Association in Amsterdam Professor Max Topp of the University of Wuerzberg in Germany presents the impressive results with a bispecific antibody for Acute Lymphoblastic Leukemia patients.

18 Jun 2012

Scientists discover master regulator gene needed for development of M cells

Scientists have found a master regulator gene needed for the development of M cells, a mysterious type of intestinal cell involved in initiating immune responses.

18 Jun 2012

Urgent need for O Negative blood donations before the Olympics

New statistics from NHS Blood and Transplant (NHSBT) announced yesterday reveal a gap between demand and supply of blood type O Rh Negative (O Negative) during national celebrations and underline an urgent need for O Negative donors to come forward ahead of the Olympics next month.

16 Jun 2012

Novel technique can restore hand function in patients with spinal cord injury

Justin M. Brown, MD, reconstructive neurosurgeon at UC San Diego Health System, is one of only a few specialists in the world who have pioneered a novel technique to restore hand function in patients with spinal cord injury. In a delicate four-hour procedure, Brown splices together tiny nerve endings, only one millimeter in width, to help restore hand mobility. Most patients return home 24 hours after surgery.

16 Jun 2012

Osiris receives consent from NZ to market Prochymal for GvHD

Osiris Therapeutics, Inc., announced today it has received consent from New Zealand to market its first-in-class stem cell therapy Prochymal (remestemcel-L), for the treatment of acute graft-vs-host disease (GvHD) in children.

15 Jun 2012

Transplantation of tissue-engineered vein is a success and offers hope for patients who lack suitable veins for dialysis or bypass surgery

The first biologically tissue-engineered vein grown from a patient’s own stem cells has been successfully transplanted into a 10-year-old girl with portal vein obstruction, dramatically enhancing her quality of life.

15 Jun 2012

Life-saving kidney transplants now available for older patients

In the past, a patient 55 or older had little or no chance of receiving a life-saving kidney transplant. But improvements in medicine have many doctors re-evaluating older patients who need a new organ.

15 Jun 2012

Study strengthens link between HHV-6B and mesial temporal lobe epilepsy

A ten-year NIH-funded study has determined that a third of infants with prolonged seizures and fever suffer from either a new or reactivated roseola virus infection. Roseola viruses are the cause of the common childhood rash, but can also cause limbic encephalitis, a condition that frequently progresses to epilepsy. Investigators discovered one of the roseola viruses, human herpesvirus-6B (HHV-6B) in the blood of 32% of 169 infants with prolonged seizures, a condition known as status epilepticus.

15 Jun 2012

Theraclone Sciences commences TCN-202 Phase 1 trial in CMV infection

Theraclone Sciences, Inc., a therapeutic antibody discovery and development company, announced today first dosing of subjects in a Phase 1 clinical trial of TCN-202, a broadly protective, fully human monoclonal antibody in development for the treatment of human cytomegalovirus (CMV) infection.

15 Jun 2012

Updated survival data from Takeda’s brentuximab vedotin Phase II trial on HL

Millennium: The Takeda Oncology Company, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, today announced updated survival data from a pivotal Phase II clinical trial of single-agent brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma (HL) after autologous stem cell transplant (ASCT) showing that the median overall survival has not been reached after a 26.5 month median follow-up.

14 Jun 2012

Two video articles describe pre-surgical preparation of corneal tissue

Over 45,000 corneal transplant eye surgeries are performed in the US every year. On June 12, 2012, in an effort to standardize this complex procedure, two video articles describing pre-surgical preparation of corneal tissue were published in JoVE, the Journal of Visualized Experiments.

13 Jun 2012

Hepatocytes can create new liver system in mouse models

Researchers in Japan have found that hepatocytes, cells comprising the main tissue of the liver and involved in protein synthesis and storage, can assist in tissue engineering and create a "new liver system" in mouse models when donor mouse liver hepatocytes are isolated and propagated for transplantation.

12 Jun 2012

Hepatitis C more prevalent among homeless adults in downtown Los Angeles

Recent government studies show that hepatitis C, which can destroy the liver and necessitate a liver transplant, now kills more American adults than AIDS, and new UCLA research shows just how prevalent the disease is among homeless adults in downtown Los Angeles.

12 Jun 2012

Fate Therapeutics, BD Biosciences introduce first collaborative iPSC-related product

Fate Therapeutics, Inc. in collaboration with BD Biosciences, a segment of BD (Becton, Dickinson and Company), today announced the introduction of the first induced pluripotent stem cell (iPSC)-related product resulting from the collaboration between the two companies.

From BD (Becton, Dickinson and Company) 11 Jun 2012

Study: U.S. Hispanics fare worse waiting for heart transplants

Hispanic patients in need of a heart transplant are 50 percent more likely to die before they get one that white patients, according to a U.S. study.

8 Jun 2012

U of M, AbSorber to evaluate XM-ONE in their Living Donor program

The transplantation unit at Jackson Memorial Hospital and the University of Miami, FL, USA has entered into a research project with the Allenex group company AbSorber. The project is a pilot study evaluating the endothelial cell cross match XM-ONE in their Living Donor program.

8 Jun 2012

Successful pregnancies common for female liver transplant recipients

New research confirms that successful pregnancies are common for female liver transplant recipients. The study appearing in the June issue of Liver Transplantation, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases, found miscarriage risk was lower and the live birth rate higher among women following liver transplantation than in the general U.S. population.

7 Jun 2012

New data supports clinical role of Cambridge Heart’s MTWA test in managing patients at risk of SCA

Cambridge Heart, Inc., a developer of non-invasive diagnostic tests for cardiac disease, today announced that results of a prospective, 155-patient trial reinforce the value of the Microvolt T-Wave Alternans (MTWA) test as a predictor of life-threatening heart rhythms and Sudden Cardiac Death (SCD).

7 Jun 2012

Studies evaluate transplantation potential and success of islet cells derived from pancreatic tissues

Two studies appearing in the current issue of Cell Transplantation, evaluate the transplantation potential and success of islet cells derived from pancreatic tissues, in addition to a clinical study that reports the occurrence of adverse events.

7 Jun 2012