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Charting the future of IBD treatment: From immune modulators to microRNA therapies

In a recent study published in the journal eGastroenterology, researchers delved into the latest therapeutic strategies for managing inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The paper discusses emerging treatments ranging from immune-modulating drugs and biologics to novel approaches like microRNA upregulators and stem cell therapies, highlighting the need for precision medicine in IBD care.

8 Nov 2023

Patients with advanced HER2-positive breast cancer live longer if treated with pyrotinib, trial shows

Patients with HER2-positive breast cancer that has started to spread to other parts of the body survive for longer if they are treated with a new drug called pyrotinib, according to results from the longest follow-up of the PHOEBE randomized clinical trial in China.

8 Nov 2023

Study finds 4% of Icelanders to carry an actionable genotype associated with shortened lifespan

Scientists at deCODE genetics, a subsidiary of Amgen, have published a study on actionable genotypes detected in the Icelandic population and their association with lifespan.

8 Nov 2023

New study reveals link between autism brain states and early life memory retention

Neuroscientists have discovered a fascinating connection between the retention of early life memories and brain developmental trajectories associated with autism [Wednesday 8th November 2023].

8 Nov 2023

Study unravels molecular basis of chronic pain transition

Researchers from the Center for Translational Immunology at University Medical Center Utrecht (the Netherlands) have identified that a transient inflammatory pain causes mitochondrial and redox changes in sensory neurons that persist beyond pain resolution.

8 Nov 2023

Study compares the immunogenicity and safety of two SARS-CoV-2 vaccines

The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019. Since then, extensive efforts have been made to develop and evaluate vaccines to combat the virus.

8 Nov 2023

Miami Dolphins and AutoNation team up to address breast cancer disparities

The Miami Dolphins and AutoNation have teamed up to fund a $1-million, four-year Breast Cancer Research Foundation (BCRF) project at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.

8 Nov 2023

Gamma delta T cells engineered to be more potent and long-lasting against cancer

UCLA scientists have developed a new method to engineer more powerful immune cells that can potentially be used for "off-the-shelf" cell therapy to treat challenging cancers.

8 Nov 2023

Allergic conditions linked to higher risk of Long-COVID, study finds

In an analysis of published prospective studies of people of all ages with confirmed SARS-CoV-2 infection who were followed for at least 12 months, pre-existing allergic conditions were linked to higher risks of experiencing long-term symptoms associated with COVID-19, or Long-COVID.

8 Nov 2023

Human tissue model reveals diversity of bacterial strategies for urinary tract infections

The research, published today in Science Advances, is the first to use a sophisticated human tissue model to explore the interaction between host and pathogen for six common species that cause urinary tract infections.

8 Nov 2023

New antifungal molecule shows promise in combatting fungal infections without toxicity

A new antifungal molecule, devised by tweaking the structure of prominent antifungal drug Amphotericin B, has the potential to harness the drug's power against fungal infections while doing away with its toxicity, researchers at the University of Illinois Urbana-Champaign and collaborators at the University of Wisconsin-Madison report in the journal Nature.

8 Nov 2023

Study sheds new light on the variety of cellular causes of rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation that leads to pain, joint damage, and disability, which affects approximately 18 million people worldwide.

8 Nov 2023

Scientists unravel the mystery of how cells keep glutathione levels in check

If a delivery person leaves a package on your front step without pinging you, you likely won't know it's there.

8 Nov 2023

Clotting risk from birth control normalizes within weeks of stopping hormonal contraceptives

Using birth control pills and other hormone-based contraceptives is known to elevate the risk of blood clots about three-fold, but a new study suggests that this risk largely goes away within two to four weeks after one stops using these contraceptives, according to research published today in Blood.

8 Nov 2023

Diabetes breakthrough: Scientists uncover novel route to stimulate beta cell growth

Researchers at Weill Cornell Medicine have uncovered a novel route to stimulate the growth of healthy insulin-producing pancreatic beta cells in a preclinical model of diabetes.

8 Nov 2023

Gene expression in nearby healthy tissue may be a better predictor of lung cancer recurrence

Genetic information collected from seemingly healthy tissue near lung tumors may be a better predictor of whether cancer will come back after treatment than analysis of the tumors themselves, according to new research led by NYU Langone Health and its Perlmutter Cancer Center.

8 Nov 2023

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Researchers at the Centre for Genomic Regulation and Vall d'Hebron Institute of Oncology have shown that the simultaneous inhibition of two different proteins may represent a new strategy for tackling triple-negative breast cancer, the most aggressive and drug-resistant form of breast cancer.

8 Nov 2023

New drug shows exciting promise for the treatment of ALS

In science, a simple but thorough observation can kick-start the most surprising findings. Researchers at the Hollings Cancer Center at the Medical University of South Carolina noticed that mice lacking a protein of interest in cancer research were showing visible signs of abnormal motor functions as they aged, including loss of coordination and strength.

8 Nov 2023

Can adding RNA sequencing to germline genetic testing improve accuracy and clinical sensitivity over time compared to DNA sequencing alone?

Concurrent sequencing of DNA and RNA to detect the predisposition to hereditary cancer.

8 Nov 2023

AI-powered radiation therapy revolutionizes cancer treatment at Henry Ford West Bloomfield Hospital

Patients undergoing radiation therapy for certain types of cancer at Henry Ford West Bloomfield Hospital are among the first in the country with access to a cutting-edge treatment system that increases accuracy and precision, enhances patient comfort, and minimizes side effects.

8 Nov 2023

Medicine News and Research

Charting the future of IBD treatment: From immune modulators to microRNA therapies

Patients with advanced HER2-positive breast cancer live longer if treated with pyrotinib, trial shows

Study finds 4% of Icelanders to carry an actionable genotype associated with shortened lifespan

New study reveals link between autism brain states and early life memory retention

Study unravels molecular basis of chronic pain transition

Study compares the immunogenicity and safety of two SARS-CoV-2 vaccines

Miami Dolphins and AutoNation team up to address breast cancer disparities

Gamma delta T cells engineered to be more potent and long-lasting against cancer

Allergic conditions linked to higher risk of Long-COVID, study finds

Human tissue model reveals diversity of bacterial strategies for urinary tract infections

New antifungal molecule shows promise in combatting fungal infections without toxicity

Study sheds new light on the variety of cellular causes of rheumatoid arthritis

Scientists unravel the mystery of how cells keep glutathione levels in check

Clotting risk from birth control normalizes within weeks of stopping hormonal contraceptives

Diabetes breakthrough: Scientists uncover novel route to stimulate beta cell growth

Gene expression in nearby healthy tissue may be a better predictor of lung cancer recurrence

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

New drug shows exciting promise for the treatment of ALS

Can adding RNA sequencing to germline genetic testing improve accuracy and clinical sensitivity over time compared to DNA sequencing alone?

AI-powered radiation therapy revolutionizes cancer treatment at Henry Ford West Bloomfield Hospital

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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