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Radiation therapy for ventricular tachycardia may revert heart muscle cells to a younger state

Radiation therapy for ventricular tachycardia — a life-threatening irregular heart rhythm — appears to work by reverting heart muscle cells to a younger state, reducing the irregular rhythms, according to a new study from Washington University School of Medicine in St. Louis.

24 Sep 2021

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress response pathway that promotes survival of cancer cells, which become sensitive to pharmacological inhibition of this pathway. These findings were published online in Cancer Research, a journal of the American Association for Cancer Research, and point to a new therapeutic opportunity for this type of ovarian cancer for which new solutions are urgently needed.

22 Sep 2021

High-fat diet or genetically induced obesity can lead to loss of hair follicles

It's well known that obesity is linked to the development of numerous diseases in humans. Heart disease, diabetes, and other ailments are extremely common in obese individuals.

21 Sep 2021

R37 MERIT Award supports innovative ovarian cancer research

One of the most impactful advancements during the past decade in treating ovarian cancer is the use of PARP inhibitors (short for poly adenosine diphosphate-ribose polymerase). PARP inhibitors are a type of cancer drug that blocks the PARP enzyme from helping to repair DNA damage in cancer cells.

18 Sep 2021

Novel combination therapy approach to keep leukemia at bay

In chronic leukemias, blocking the overactive kinase JAK2 by a targeted therapy approach is only mitigating the patients' symptoms, but cannot truly change the course of the disease.

16 Sep 2021

A family of proteins may be able to outwit emerging and re-emerging viruses

A family of proteins best known for their role in diminishing HIV infectivity may have the goods to outwit other emerging and re-emerging viruses, scientists have found.

15 Sep 2021

Flu shots and COVID-19 immunity

A new paper finds that the influenza vaccine may influence both the response to and incidence of infection by the SARS-CoV-2.

14 Sep 2021

Immune cells present in tumors from head and neck cancer patients, study reports

A new study from scientists at Emory Vaccine Center and Winship Cancer Institute of Emory University reports that the immune cells that are the major targets of immune checkpoint inhibitors are present in tumors from head and neck cancer patients.

2 Sep 2021

Cultured cartilage cells from the nasal septum could help relieve osteoarthritis in the knee

Cartilage cells from the nasal septum can not only help repair cartilage injuries in the knee – according to researchers from the University of Basel and the University Hospital of Basel, they can also withstand the chronic inflammatory tissue environment in osteoarthritis and even counteract the inflammation.

1 Sep 2021

Researchers convert human stem cells into beta cells using small molecules

The human body can be genetically inclined to attack its own cells, destroying the beta cells in the pancreas that make insulin, which helps convert sugar into energy.

27 Aug 2021

Researchers reveal mechanism underlying most common cause of epileptic seizures

During fetal development, cells should migrate to the outer edge of the brain to form critical connections for information transfer and regulation in the body.

26 Aug 2021

Researchers identify a brief window of opportunity to prevent NF1-associated optic pathway glioma

Researchers at Children's National Hospital identified a vulnerability in a developmental signaling pathway that can be hijacked to drive pediatric low-grade glioma (pLGG) formation, according to a pre-clinical study published in Developmental Cell.

23 Aug 2021

Study: PirB inhibits the self-renewal and differentiation capacities of neural stem cells

Aging-US published "PirB functions as an intrinsic suppressor in hippocampal neural stem cells" which reported that neural stem cells play pivotal roles during prenatal development and throughout life.

20 Aug 2021

Arteriolar niche used by breast cancer cells to prepare for metastasis

More than 43,000 American women will die from breast cancer this year. Most of those deaths will occur after the cancer has spread to other organs, a process called metastasis. This involves at least five major steps.

19 Aug 2021

Scientists identify the main components driving amyloid beta-associated synapse degeneration

Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous system.

18 Aug 2021

SARS-CoV-2 ORF8 and the expression of cytokine in human macrophages

A new study has determined the production of the SARS-CoV-2 SP-dependent ORF8.

18 Aug 2021

Severe COVID-19 characterized by phosphorylation of STAT1

A new study reports an enhanced expression of STAT1 in mild and severely infected COVID-19 patients as compared to controls

18 Aug 2021

Blue light can activate key signaling pathway that plays role in embryonic development and cancer

Blue light is illuminating new understanding of a key signaling pathway in embryo development, tissue maintenance and cancer genesis.

17 Aug 2021

Hedgehog-signaling inhibitor may shift tumor-associated macrophages back to cancer fighters

A form of cell communication called hedgehog signaling is vital for embryonic development in mammals.

16 Aug 2021

Understanding hypoxia-induced gene expression variations in aggressive type of pancreatic cancer

Cancer cells have evolved a myriad of mechanisms that support their uncontrolled growth. In case of solid tissue tumors, the tumor microenvironment, which consists of extracellular components and conditions surrounding the tumor, is crucial in deciding the fate of the cancer cells.

11 Aug 2021

Signaling Pathway News and Research

Radiation therapy for ventricular tachycardia may revert heart muscle cells to a younger state

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

High-fat diet or genetically induced obesity can lead to loss of hair follicles

R37 MERIT Award supports innovative ovarian cancer research

Novel combination therapy approach to keep leukemia at bay

A family of proteins may be able to outwit emerging and re-emerging viruses

Flu shots and COVID-19 immunity

Immune cells present in tumors from head and neck cancer patients, study reports

Cultured cartilage cells from the nasal septum could help relieve osteoarthritis in the knee

Researchers convert human stem cells into beta cells using small molecules

Researchers reveal mechanism underlying most common cause of epileptic seizures

Researchers identify a brief window of opportunity to prevent NF1-associated optic pathway glioma

Study: PirB inhibits the self-renewal and differentiation capacities of neural stem cells

Arteriolar niche used by breast cancer cells to prepare for metastasis

Scientists identify the main components driving amyloid beta-associated synapse degeneration

SARS-CoV-2 ORF8 and the expression of cytokine in human macrophages

Severe COVID-19 characterized by phosphorylation of STAT1

Blue light can activate key signaling pathway that plays role in embryonic development and cancer

Hedgehog-signaling inhibitor may shift tumor-associated macrophages back to cancer fighters

Understanding hypoxia-induced gene expression variations in aggressive type of pancreatic cancer

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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