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Lipid droplets play an unexpected role in embryo development

Histones are proteins needed to assemble DNA molecules into chromosomes. They have long represented a classic balancing act in biology; too few histone molecules result in DNA damage, while too many histones are toxic to the cell. New research at the University of Rochester is causing a fundamental shift in the concept of histone balance and the mechanism behind it.

19 Oct 2012

Weill Cornell Medical College researcher wins 2012 William B. Coley Award

Dr. Laurie H. Glimcher, the Stephen and Suzanne Weiss Dean of Weill Cornell Medical College and provost for medical affairs of Cornell University, is a winner of the 2012 William B. Coley Award for Distinguished Research in Basic Immunology from the Cancer Research Institute for her outstanding achievements in immunology and cancer research.

19 Oct 2012

Study identifies new risk factors for bladder cancer

Low depressive symptoms and a longer telomere length are compelling factors that contribute to a prolonged life for bladder cancer patients according to researchers at The University of Texas MD Anderson Cancer Center.

19 Oct 2012

Lupus investigators receive LRI's first $1 million research grants

The Lupus Research Institute (LRI) today announced the first $1 million research grants given to lupus investigators by a private research organization.

19 Oct 2012

BioResearch Open Access explores Cell-SELEX technology

SELEX is a rapid, efficient, and iterative high-throughput method for screening large libraries of molecules to identify those with the potential to be developed as drug compounds or research tools. Advances in SELEX technology that have enabled screening in live cells, called Cell-SELEX, are explored in a comprehensive Review article published in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc.

19 Oct 2012

New ultrasound technique can rapidly separate selected live cells for use in biomedical research

Researchers from North Carolina State University and University of North Carolina at Chapel Hill have developed a new technique that uses sound waves to rapidly separate selected collections of cells for use in biomedical research.

19 Oct 2012

Novel insight into impact that Huntington's disease has on the brain

A study led by researchers at Boston University School of Medicine (BUSM) provides novel insight into the impact that Huntington's disease has on the brain.

19 Oct 2012

New book focuses on Wnt signaling

Wnt proteins are signaling molecules that play critical roles during embryonic development and in the regeneration of adult tissues. They bind to Frizzled and LRP family receptors on the cell surface, triggering a series of events that cause beta-catenin to enter the nucleus and activate transcription factors that control cell fate and cell proliferation. Mutations in components of the Wnt pathway lead to developmental defects and are common in cancer.

19 Oct 2012

Study sheds light on how overeating can lead to obesity and diabetes

New research from Mount Sinai School of Medicine sheds light on how overeating can cause a malfunction in brain insulin signaling, and lead to obesity and diabetes. Christoph Buettner, MD, PhD, Associate Professor of Medicine (Endocrinology, Diabetes and Bone Disease) and his research team found that overeating impairs the ability of brain insulin to suppress the breakdown of fat in adipose tissue.

19 Oct 2012

New way to image how brain cells coordinate with each other to control specific behaviors

A team led by MIT neuroscientists has developed a way to monitor how brain cells coordinate with each other to control specific behaviors, such as initiating movement or detecting an odor.

19 Oct 2012

Two opposing mechanisms support voluntary forgetting of unwanted memories

If only there were a way to forget that humiliating faux pas at last night's dinner party. It turns out there's not one, but two opposite ways in which the brain allows us to voluntarily forget unwanted memories, according to a study published by Cell Press October 17 in the journal Neuron.

19 Oct 2012

Neuralstem initiates second cohort NSI-189 Phase Ib trial in major depressive disorder

Neuralstem, Inc. announced that it has begun dosing the second cohort of patients in its ongoing Phase Ib to test the safety of NSI-189 in the treatment of major depressive disorder (MDD).

19 Oct 2012

Quick, cheap eye scan can predict brain damage in people with multiple sclerosis

An inexpensive, five-minute eye scan can accurately assess the amount of brain damage in people with the debilitating autoimmune disorder multiple sclerosis (MS), and offer clues about how quickly the disease is progressing, according to results of two Johns Hopkins studies.

19 Oct 2012

Viewpoints: 'Scrappy' debate offered little new on entitlement programs; Staring down the fiscal cliff

President Obama and Mitt Romney faced off Tuesday night in a scrappy, at times downright nasty town-hall debate that featured a feistier, more focused Obama than was seen in their first encounter and that broadened the discussion to social issues such as immigration, contraceptive coverage and gun control. ... In the end, on the domestic front, the debate performance of both has been about as disappointing as their dodging on the campaign trail.

19 Oct 2012

Long-term multivitamin use associated with prevention of cancer in middle-aged and older men

In a randomized trial that included nearly 15,000 male physicians, long-term daily multivitamin use resulted in a modest but statistically significant reduction in cancer after more than a decade of treatment and follow-up, according to a study appearing in JAMA.

19 Oct 2012

Ustekinumab shows positive results in decreasing debilitating effects of Crohn's Disease

Ustekinumab, an antibody proven to treat the skin condition psoriasis, has now shown positive results in decreasing the debilitating effects of Crohn's Disease, according to researchers at the University of California San Diego, School of Medicine.

18 Oct 2012

New research sheds light on consequence of overeating

New research from Mount Sinai School of Medicine sheds light on how overeating can cause a malfunction in brain insulin signaling, and lead to obesity and diabetes.

18 Oct 2012

Researchers identify painful symptoms of sickle cell disease

Researchers at Drexel University have identified the physical forces in red blood cells and blood vessels underlying the painful symptoms of sickle cell disease.

18 Oct 2012

Phase 3 study of INLYTA fails to meet primary endpoint in treatment-naïve patients with RCC

Pfizer Inc. announced today that a Phase 3 study of INLYTA (axitinib) did not meet its primary endpoint of demonstrating statistically significantly longer progression-free survival, versus sorafenib, in treatment-naïve patients with advanced renal cell carcinoma.

18 Oct 2012

Research may lead to new ways to identify women with breast cancer risks from low-dose radiation

Scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory have identified tissue mechanisms that may influence a woman's susceptibility or resistance to breast cancer after exposure to low-dose ionizing radiation, such as the levels used in full-body CT scans and radiotherapy.

18 Oct 2012

Cell News and Research

Lipid droplets play an unexpected role in embryo development

Weill Cornell Medical College researcher wins 2012 William B. Coley Award

Study identifies new risk factors for bladder cancer

Lupus investigators receive LRI's first $1 million research grants

BioResearch Open Access explores Cell-SELEX technology

New ultrasound technique can rapidly separate selected live cells for use in biomedical research

Novel insight into impact that Huntington's disease has on the brain

New book focuses on Wnt signaling

Study sheds light on how overeating can lead to obesity and diabetes

New way to image how brain cells coordinate with each other to control specific behaviors

Two opposing mechanisms support voluntary forgetting of unwanted memories

Neuralstem initiates second cohort NSI-189 Phase Ib trial in major depressive disorder

Quick, cheap eye scan can predict brain damage in people with multiple sclerosis

Viewpoints: 'Scrappy' debate offered little new on entitlement programs; Staring down the fiscal cliff

Long-term multivitamin use associated with prevention of cancer in middle-aged and older men

Ustekinumab shows positive results in decreasing debilitating effects of Crohn's Disease

New research sheds light on consequence of overeating

Researchers identify painful symptoms of sickle cell disease

Phase 3 study of INLYTA fails to meet primary endpoint in treatment-naïve patients with RCC

Research may lead to new ways to identify women with breast cancer risks from low-dose radiation

What are the challenges of cell line development? eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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