Oligonucleotides News and Research

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Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer bases. Automated synthesizers allow the synthesis of oligonucleotides up to 160 to 200 bases.

Weill Cornell experts publish review of genetic medicine

In an article published in the April issue of Nature Reviews Genetics, two experts at the Weill Medical College of Cornell University sum up the achievements, challenges and promise of a burgeoning field: genetic medicine.

3 Apr 2006

Bioniche granted patent for oligonucleotide technology

Bioniche Life Sciences has announced that it has been granted a European patent - EP1432450 - covering the composition and use of a novel oligonucleotide family for the treatment of cancer entitled: "Therapeutically Useful Triethyleneglycol Cholesteryl Oligonucleotides"

17 Mar 2006

Sirna Therapeutics awarded patent covering large-scale synthesis of RNAi-based therapeutics

Sirna Therapeutics has announced that the United States Patent and Trademark Office (USPTO) has granted Sirna U.S. Patent No. 6,989,442 for the chemical synthesis and manufacturing of ribonucleic acids (RNA).

25 Jan 2006

Edifoligide no better than placebo for clogged veins

A new drug, edifoligide, designed to prevent the clogging of veins used in coronary bypass surgery was no more effective than a placebo, according to the results of a Phase III clinical trial led by researchers at Duke Clinical Research Institute (DCRI).

14 Nov 2005

Nanogen subsidiary, Epoch Biosciences issued new patent

Nanogen announced today its subsidiary, Epoch Biosciences, was issued Patent No. 6,951,930, "Hybridization-Triggered Fluorescent Detection of Nucleic Acids" by the U.S. Patent and Trademark Office.

11 Oct 2005

Human embryonic stem cell lines accumulate changes in their genetic material over time

The findings do not limit the utility of the cells for some types of research or for some future clinical applications, the researchers say, but draw attention to the need to closely monitor stem cell lines for genetic changes and to study how these alterations affect the cells' behavior.

6 Sep 2005

Human embryonic stem cell lines accumulate changes in their genetic material over time

5 Sep 2005

A new method for manipulating macromolecules

The technique uses double-stranded DNA to direct the behavior of other molecules. In previous DNA nanotechnology efforts, duplex DNA has been used as a static lattice to construct geometrical objects in three dimensions.

29 Jun 2005

New clues about the location of genes potentially involved in the most common type of lung cancer

Using technology that makes it possible to zoom in on smaller sections of cell chromosomes than ever before, researchers at Dana-Farber Cancer Institute have identified nearly 100 chromosome regions where genes are either over-copied or missing in non-small cell lung cancer.

27 Jun 2005

Lorus Therapeutics receives patent allowance to protect novel anticancer drug

Lorus Therapeutics today announced that its wholly owned subsidiary, GeneSense Technologies Inc. (GeneSense), has received notice from the European Patent Office of its intention to grant GeneSense's application for a patent of its novel antisense drug, GTI-2501.

9 Jun 2005

Hybridon collaborates to develop immune modulatory (IMO) compounds for asthma and allergy

Hybridon today announced it had entered into research collaboration and license agreements with Novartis for the discovery, optimization, development and commercialization of Toll-like receptor 9 (TLR9) drug candidates targeting asthma and allergy based on Hybridon's proprietary immune modulatory oligonucleotide (IMO) technology platform.

1 Jun 2005

Technology for analyzing gene expression must be standardized

Technology for analyzing gene expression must be standardized among laboratories and across platforms around the world to support this age of human genome exploration, an Oregon Health & Science University researcher says.

29 May 2005

Novel nanotechnology detects human DNA mutations

Researchers at Nanosphere, Inc. have reported unprecedented benefits in the company's technology for the medical analysis of human DNA.

26 Jan 2005

FDA approves Topigen's investigational New Drug Application for new inhalation drug to treat asthma

Phase 1 clinical trial can be initiated for ASM8, a new inhalation drug that is designed to treat asthma through a unique approach by attacking multiple mediators of the inflammatory mechanism rather than the single mediator approach of current therapies.

8 Dec 2004

Lorus Therapeutics allowed Canadian patent to protect anticancer drugs

Lorus Therapeutics today announced that its wholly owned subsidiary, GeneSense Technologies Inc., has been allowed a patent by the Canadian Patent Office entitled "Antitumor Antisense Sequences Directed Against R1 and R2 Components of Ribonucleotide Reductase."

10 Nov 2004

STAT3 protein could lead to new ways to prevent skin cancer

Scientists at The University of Texas M. D. Anderson Cancer Center have identified a protein that serves as a master regulator of skin cancer - a finding that could lead to new ways to prevent skin cancer before it starts.

4 Nov 2004

Researchers discover that DNA fragments destroy melanoma cells

Researchers at Boston University School of Medicine have discovered that small DNA fragments or oligonucleotides that resemble the telomere (chromosome end), also called T-oligos, can cause human melanoma cells to undergo extensive apoptosis (cell death), while surviving melanoma cells become more differentiated and therefore less aggressive.

1 Sep 2004

New service-oriented laboratory focused on bioanalysis and pharmacokinetics

Oregon Health & Science University researchers will more quickly move benchtop discoveries toward drug discoveries with the help of a new, service-oriented laboratory focused on bioanalysis and pharmacokinetics.

11 Aug 2004

Total global market for oligonucleotides is likely to grow from USD 340.0 million in 2003 to USD 776.0 million in 2010

Poised on the brink of phenomenal growth, the oligonucleotides market offers a plethora of opportunities to the enterprising investor. Recent analysis by Frost & Sullivan estimates that the total global market for oligonucleotides is likely to grow from USD 340.0 million in 2003 to USD 776.0 million in 2010.

9 Aug 2004

Surprising differences in the DNA of normal cells from different people

A new study by Michael Wigler’s group at Cold Spring Harbor Laboratory has, in collaboration with researchers from Karolinska Institutet, revealed surprising differences in the DNA of normal cells from different people.

23 Jul 2004

Oligonucleotides News and Research

Further Reading

Weill Cornell experts publish review of genetic medicine

Bioniche granted patent for oligonucleotide technology

Sirna Therapeutics awarded patent covering large-scale synthesis of RNAi-based therapeutics

Edifoligide no better than placebo for clogged veins

Nanogen subsidiary, Epoch Biosciences issued new patent

Human embryonic stem cell lines accumulate changes in their genetic material over time

Human embryonic stem cell lines accumulate changes in their genetic material over time

A new method for manipulating macromolecules

New clues about the location of genes potentially involved in the most common type of lung cancer

Lorus Therapeutics receives patent allowance to protect novel anticancer drug

Hybridon collaborates to develop immune modulatory (IMO) compounds for asthma and allergy

Technology for analyzing gene expression must be standardized

Novel nanotechnology detects human DNA mutations

FDA approves Topigen's investigational New Drug Application for new inhalation drug to treat asthma

Lorus Therapeutics allowed Canadian patent to protect anticancer drugs

STAT3 protein could lead to new ways to prevent skin cancer

Researchers discover that DNA fragments destroy melanoma cells

New service-oriented laboratory focused on bioanalysis and pharmacokinetics

Total global market for oligonucleotides is likely to grow from USD 340.0 million in 2003 to USD 776.0 million in 2010

Surprising differences in the DNA of normal cells from different people

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